Global cancer statistics, 2012
Lindsey A. Torre,Freddie Bray,Rebecca L. Siegel,Jacques Ferlay,Joannie Lortet-Tieulent,Ahmedin Jemal +5 more
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TLDR
A substantial portion of cancer cases and deaths could be prevented by broadly applying effective prevention measures, such as tobacco control, vaccination, and the use of early detection tests.Abstract:
Cancer constitutes an enormous burden on society in more and less economically developed countries alike. The occurrence of cancer is increasing because of the growth and aging of the population, as well as an increasing prevalence of established risk factors such as smoking, overweight, physical inactivity, and changing reproductive patterns associated with urbanization and economic development. Based on GLOBOCAN estimates, about 14.1 million new cancer cases and 8.2 million deaths occurred in 2012 worldwide. Over the years, the burden has shifted to less developed countries, which currently account for about 57% of cases and 65% of cancer deaths worldwide. Lung cancer is the leading cause of cancer death among males in both more and less developed countries, and has surpassed breast cancer as the leading cause of cancer death among females in more developed countries; breast cancer remains the leading cause of cancer death among females in less developed countries. Other leading causes of cancer death in more developed countries include colorectal cancer among males and females and prostate cancer among males. In less developed countries, liver and stomach cancer among males and cervical cancer among females are also leading causes of cancer death. Although incidence rates for all cancers combined are nearly twice as high in more developed than in less developed countries in both males and females, mortality rates are only 8% to 15% higher in more developed countries. This disparity reflects regional differences in the mix of cancers, which is affected by risk factors and detection practices, and/or the availability of treatment. Risk factors associated with the leading causes of cancer death include tobacco use (lung, colorectal, stomach, and liver cancer), overweight/obesity and physical inactivity (breast and colorectal cancer), and infection (liver, stomach, and cervical cancer). A substantial portion of cancer cases and deaths could be prevented by broadly applying effective prevention measures, such as tobacco control, vaccination, and the use of early detection tests.read more
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MicroRNA in diagnosis and therapy monitoring of early-stage triple-negative breast cancer
Mustafa Kahraman,Anne Röske,Thomas Laufer,Tobias Fehlmann,Christina Backes,Fabian Kern,Jochen Kohlhaas,Hannah Schrörs,Anna Saiz,Cassandra Zabler,Nicole Ludwig,Peter A. Fasching,Reiner Strick,Matthias Rübner,Matthias W. Beckmann,Eckart Meese,Andreas Keller,Michael G. Schrauder +17 more
TL;DR: It is reported that miRNA expression measured from blood facilitates early and minimally-invasive diagnosis of basal-like TNBC and that blood-borne miRNA profiles monitored over time have potential to predict pathological complete response (pCR).
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Learning Curve for Robot-Assisted Minimally Invasive Thoracoscopic Esophagectomy: Results From 312 Cases.
Pieter C. van der Sluis,Jelle P. Ruurda,Sylvia van der Horst,Lucas Goense,Richard van Hillegersberg +4 more
TL;DR: The learning phase of thoracic laparoscopic robot-assisted minimally invasive esophagectomy RAMIE consisted of 70 procedures in 55 months and a structured proctoring for RAMIE substantially reduced the number of procedures and time required to achieve proficiency.
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Histone methyltransferase KMT2D sustains prostate carcinogenesis and metastasis via epigenetically activating LIFR and KLF4.
Shidong Lv,Shidong Lv,Liyan Ji,Bin Chen,Shuqiang Liu,Chengyong Lei,Xi Liu,Xiaoxiao Qi,Ying Wang,Elaine Lai-Han Leung,Hongyi Wang,Lin Zhang,Xiao-Ming Yu,Zhongqiu Liu,Zhongqiu Liu,Qiang Wei,Linlin Lu,Linlin Lu +17 more
TL;DR: It is revealed that KMT2D epigenetically activates PI3K/Akt pathway and EMT by targeting LIFR and KLF4 and thus serves as a putative epigenetic-based target for treating PCa.
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The mutational landscape of hepatocellular carcinoma
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Prognostic role of the neutrophil-to-lymphocyte ratio in pancreatic cancer: A meta-analysis containing 8252 patients.
TL;DR: It was revealed that low NLR was a favorable predictor of OS and DFS in patients with pancreatic cancer, and NLR is a promising prognostic biomarker for Pancreatic cancer.
References
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Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012.
Jacques Ferlay,Isabelle Soerjomataram,Rajesh Dikshit,Sultan Eser,Colin Mathers,Marise Souto Rebelo,Donald Maxwell Parkin,David Forman,Freddie Bray +8 more
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Journal ArticleDOI
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Book
Cancer Incidence in Five Continents
Freddie Bray,J. Ferlay,Mathieu Laversanne,David H. Brewster,C. Gombe Mbalawa,B. Kohler,Marion Piñeros,Eva Steliarova-Foucher,Rajaraman Swaminathan,Sebastien Antoni,Isabelle Soerjomataram,David Forman +11 more
TL;DR: The aim of this study was to establish a database of histological groups and to provide a level of consistency and quality of data that could be applied in the design of future registries.
Journal ArticleDOI
Reduced lung-cancer mortality with low-dose computed tomographic screening.
Denise R. Aberle,Amanda M. Adams,Christine D. Berg,William C. Black,Jonathan D. Clapp,Richard M. Fagerstrom,Ilana F. Gareen,Constantine Gatsonis,Pamela M. Marcus,JoRean D. Sicks +9 more
TL;DR: Screening with the use of low-dose CT reduces mortality from lung cancer, as compared with the radiography group, and the rate of death from any cause was reduced.