Journal ArticleDOI
Global outbreak of severe Mycobacterium chimaera disease after cardiac surgery: a molecular epidemiological study
Jakko van Ingen,Thomas Kohl,Katharina Kranzer,Barbara Hasse,Peter M. Keller,Anna K. Szafrańska,Doris Hillemann,Meera Chand,Meera Chand,Meera Chand,Peter W Schreiber,Rami Sommerstein,Rami Sommerstein,Christoph Berger,Michele Genoni,Christian Rüegg,Nicolas Troillet,Andreas F. Widmer,Sören L. Becker,Sören L. Becker,Mathias Herrmann,Tim Eckmanns,Sebastian Haller,Christiane Höller,Sylvia B. Debast,Maurice J H M Wolfhagen,Joost Hopman,Jan Kluytmans,Merel Langelaar,Daan W. Notermans,Jaap ten Oever,Peter van den Barselaar,Alexander B.A. Vonk,Margreet C. Vos,Nada Ahmed,Tim Brown,Derrick W. Crook,Derrick W. Crook,Theresa Lamagni,Nick Phin,E. Grace Smith,Maria Zambon,Annerose Serr,Tim Götting,W. Ebner,Alexander Thürmer,Christian Utpatel,Cathrin Spröer,Boyke Bunk,Ulrich Nübel,Guido V. Bloemberg,Erik C. Böttger,Stefan Niemann,Dirk Wagner,Hugo Sax +54 more
TLDR
HCU contamination with M chimaera at the LivaNova factory seems a likely source for cardiothoracic surgery-related severe M chimeera infections diagnosed in Switzerland, Germany, the Netherlands, the UK, the USA, and Australia.Abstract:
Summary Background Since 2013, over 100 cases of Mycobacterium chimaera prosthetic valve endocarditis and disseminated disease were notified in Europe and the USA, linked to contaminated heater–cooler units (HCUs) used during cardiac surgery. We did a molecular epidemiological investigation to establish the source of these patients' disease. Methods We included 24 M chimaera isolates from 21 cardiac surgery-related patients in Switzerland, Germany, the Netherlands, and the UK, 218 M chimaera isolates from various types of HCUs in hospitals, from LivaNova (formerly Sorin; London, UK) and Maquet (Rastatt, Germany) brand HCU production sites, and unrelated environmental sources and patients, as well as eight Mycobacterium intracellulare isolates. Isolates were analysed by next-generation whole-genome sequencing using Illumina and Pacific Biosciences technologies, and compared with published M chimaera genomes. Findings Phylogenetic analysis based on whole-genome sequencing of 250 isolates revealed two major M chimaera groups. Cardiac surgery-related patient isolates were all classified into group 1, in which all, except one, formed a distinct subgroup. This subgroup also comprised isolates from 11 cardiac surgery-related patients reported from the USA, most isolates from LivaNova HCUs, and one from their production site. Isolates from other HCUs and unrelated patients were more widely distributed in the phylogenetic tree. Interpretation HCU contamination with M chimaera at the LivaNova factory seems a likely source for cardiothoracic surgery-related severe M chimaera infections diagnosed in Switzerland, Germany, the Netherlands, the UK, the USA, and Australia. Protective measures and heightened clinician awareness are essential to guarantee patient safety. Funding Partly funded by the EU Horizon 2020 programme, its FP7 programme, the German Center for Infection Research (DZIF), the Swiss National Science Foundation, the Swiss Federal Office of Public Health, and National Institute of Health Research Oxford Health Protection Research Units on Healthcare Associated Infection and Antimicrobial Resistance.read more
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Association of Healthcare and Aesthetic Procedures with Infections Caused by Nontuberculous Mycobacteria, France, 2012‒2020
Côme Daniau,Emmanuel Lecorche,Faiza Mougari,Hanaa Benmansour,Claude Bernet,Hervé Blanchard,Jérôme Robert,Anne Berger-Carbonne,Emmanuelle Cambau +8 more
TL;DR: NTM infections during 2012–2020 associated with health care and aesthetic procedures in France could be preventable by using sterile water in all invasive procedures.
Journal ArticleDOI
Fast update of undetected Mycobacterium chimaera infections to reveal unsuspected cases.
Fermín Acosta,Laura Pérez-Lago,M.J. Ruiz Serrano,Mercedes Marín,Thomas Kohl,Nuria Lozano,Stefan Niemann,M. Valerio,María Olmedo,M. J. Pérez-Granda,M.R. Pérez Pérez,Emilio Bouza,Patricia Muñoz,D. García de Viedma +13 more
TL;DR: W Whole-genome sequencing demonstrated that he was the first case in Spain with involvement of the strain responsible for the global outbreak, and highlights the relevance of retrospective tracking for undetected M. chimaera infections.
Journal ArticleDOI
Updated Experience of Mycobacterium chimaera Infection: Diagnosis and Management in a Tertiary Care Center.
Nicholas Y. Tan,Alex D Tarabochia,Daniel C. DeSimone,Christopher V. DeSimone,John W. Wilson,Gabor Bagameri,Courtney Bennett,Omar Abu Saleh +7 more
TL;DR: In this article, the authors retrospectively reviewed confirmed cases of Mycobacterium chimaera infections (MCI) that were managed at Mayo Clinic sites (Arizona, Florida, and Minnesota) from 09/2015 to 01/2021.
Journal ArticleDOI
Infections with Mycobacterium chimaera and open chest surgery. An unresolved problem.
TL;DR: The epidemiological investigations have shown that the majority of infections have a common source: contaminated normo-hypothermia modules, which can be contaminated with M. chimaera, and disperse it into the air in the operating room.
Journal ArticleDOI
Cluster of Burkholderia cepacia Complex Infections Associated with Extracorporeal Membrane Oxygenation Water Heater Devices.
Chanu Rhee,Meghan A Baker,Robert Tucker,Vineeta Vaidya,M Holtzman,Raghu Seethala,M. Bentain-Melanson,Jesslyn Lenox,Adam R Smith,Jon C Boyer,Alison Gassett,Manfred Brigl,Mohamad R. Abdul Sater,Miriam H. Huntley,Ann E. Woolley,Hilary J. Goldberg,Karen M. Reilly,Andrew Resnick,Madelyn Pearson,Michael Klompas +19 more
TL;DR: A cluster of 8 B.cepacia complex infections in cardiothoracic ICU patients attributed to contaminated ECMO water heaters underscores the potential risks associated with water-based ECMO heaters and, more broadly, water- based care for vulnerable patients.
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