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Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease 2017 Report: GOLD Executive Summary.

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TLDR
The assessment of chronic obstructive pulmonary disease has been refined to separate the spirometric assessment from symptom evaluation, and the importance of comorbid conditions in managing COPD is reviewed.
Abstract
This Executive Summary of the Global Strategy for the Diagnosis, Management, and Prevention of COPD (GOLD) 2017 Report focuses primarily on the revised and novel parts of the document. The most significant changes include: 1) the assessment of chronic obstructive pulmonary disease has been refined to separate the spirometric assessment from symptom evaluation. ABCD groups are now proposed to be derived exclusively from patient symptoms and their history of exacerbations; 2) for each of the groups A to D, escalation strategies for pharmacological treatments are proposed; 3) the concept of de-escalation of therapy is introduced in the treatment assessment scheme; 4) nonpharmacologic therapies are comprehensively presented and; 5) the importance of comorbid conditions in managing COPD is reviewed.

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Global, regional, and national deaths, prevalence, disability-adjusted life years, and years lived with disability for chronic obstructive pulmonary disease and asthma, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015

Joan B. Soriano, +132 more
TL;DR: The GBD study provides annual updates on estimates of deaths, prevalence, and disability-adjusted life years (DALYs), a summary measure of fatal and non-fatal disease outcomes, for over 300 diseases and injuries, for 188 countries from 1990 to the most recent year.
Journal ArticleDOI

Exacerbations of COPD

TL;DR: The importance of preventing exacerbations of COPD is highlighted, including choice of pharmacotherapy, including bronchodilators, inhaled corticosteroids, phosphodiesterase-4 inhibitors, long-term antibiotics and mucolytics.
References
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Journal ArticleDOI

"GOLD or lower limit of normal definition? A comparison with expert-based diagnosis of chronic obstructive pulmonary disease in a prospective cohort-study".

TL;DR: GOLD criteria over-diagnosed COPD, while LLN definitions under-diagnose COPD in elderly patients as compared to an expert panel diagnosis, and incorporation of FEV1 and RV/TLC into the GOLD-COPD or LLN-based definition brings both definitions closer to expert paneldiagnosis, and to daily clinical practice.
Journal ArticleDOI

Augmentation therapy for alpha1 antitrypsin deficiency: a meta-analysis.

TL;DR: This meta-analysis supports the conclusion that augmentation can slow lung function decline in patients with AAT deficiency and patients with moderate obstruction are most likely to benefit.
Journal ArticleDOI

Use of inhaled corticosteroids and the risk of tuberculosis

TL;DR: ICS use increases the risk of TB in an intermediate-TB-burden country and Clinicians should be aware of the possibility of TB development among patients who are long-term high-dose ICS users.
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Dual bronchodilation with QVA149 reduces patient-reported dyspnoea in COPD: the BLAZE study

TL;DR: Once-daily QVA149 provided superior improvements in patient-reported dyspnoea and lung function versus placebo and tiotropium and these benefits were associated with improvements in other symptoms and reduced use of rescue medication.
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