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Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease 2017 Report: GOLD Executive Summary.

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TLDR
The assessment of chronic obstructive pulmonary disease has been refined to separate the spirometric assessment from symptom evaluation, and the importance of comorbid conditions in managing COPD is reviewed.
Abstract
This Executive Summary of the Global Strategy for the Diagnosis, Management, and Prevention of COPD (GOLD) 2017 Report focuses primarily on the revised and novel parts of the document. The most significant changes include: 1) the assessment of chronic obstructive pulmonary disease has been refined to separate the spirometric assessment from symptom evaluation. ABCD groups are now proposed to be derived exclusively from patient symptoms and their history of exacerbations; 2) for each of the groups A to D, escalation strategies for pharmacological treatments are proposed; 3) the concept of de-escalation of therapy is introduced in the treatment assessment scheme; 4) nonpharmacologic therapies are comprehensively presented and; 5) the importance of comorbid conditions in managing COPD is reviewed.

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Global, regional, and national deaths, prevalence, disability-adjusted life years, and years lived with disability for chronic obstructive pulmonary disease and asthma, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015

Joan B. Soriano, +132 more
TL;DR: The GBD study provides annual updates on estimates of deaths, prevalence, and disability-adjusted life years (DALYs), a summary measure of fatal and non-fatal disease outcomes, for over 300 diseases and injuries, for 188 countries from 1990 to the most recent year.
Journal ArticleDOI

Exacerbations of COPD

TL;DR: The importance of preventing exacerbations of COPD is highlighted, including choice of pharmacotherapy, including bronchodilators, inhaled corticosteroids, phosphodiesterase-4 inhibitors, long-term antibiotics and mucolytics.
References
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A Randomized Clinical Trial of a 1 -Antitrypsin Augmentation Therapy

TL;DR: For example, Dirksen et al. as discussed by the authors investigated whether restoration of the balance between neutrophil elastase and its inhibitor, a 1 -antitrypsin, can prevent the progression of pulmonary emphysema in patients with a deficiency.
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Bronchiectasis, exacerbation indices, and inflammation in chronic obstructive pulmonary disease.

TL;DR: Evidence of moderate lower lobe bronchiectasis on HRCT is common in COPD and is associated with more severe COPD exacerbations, lower airway bacterial colonization, and increased sputum inflammatory markers.

E-cigarettes: an evidence update. A report commissioned by Public Health England.

TL;DR: There is no evidence that EC are undermining the long-term decline in cigarette smoking among adults and youth, and may in fact be contributing to it, and new regulations currently planned should also maximise the public health opportunities of EC.
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The Italian multicentre study on noninvasive ventilation in chronic obstructive pulmonary disease patients

TL;DR: The addition of noninvasive positive-pressure ventilation to long-term oxygen therapy in stable chronic obstructive pulmonary disease patients with chronic ventilatory failure slightly decreased the trend to carbon dioxide retention in patients receiving oxygen at home and improved dyspnoea and health-related quality of life.
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