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Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease 2017 Report: GOLD Executive Summary.

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TLDR
The assessment of chronic obstructive pulmonary disease has been refined to separate the spirometric assessment from symptom evaluation, and the importance of comorbid conditions in managing COPD is reviewed.
Abstract
This Executive Summary of the Global Strategy for the Diagnosis, Management, and Prevention of COPD (GOLD) 2017 Report focuses primarily on the revised and novel parts of the document. The most significant changes include: 1) the assessment of chronic obstructive pulmonary disease has been refined to separate the spirometric assessment from symptom evaluation. ABCD groups are now proposed to be derived exclusively from patient symptoms and their history of exacerbations; 2) for each of the groups A to D, escalation strategies for pharmacological treatments are proposed; 3) the concept of de-escalation of therapy is introduced in the treatment assessment scheme; 4) nonpharmacologic therapies are comprehensively presented and; 5) the importance of comorbid conditions in managing COPD is reviewed.

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Global, regional, and national deaths, prevalence, disability-adjusted life years, and years lived with disability for chronic obstructive pulmonary disease and asthma, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015

Joan B. Soriano, +132 more
TL;DR: The GBD study provides annual updates on estimates of deaths, prevalence, and disability-adjusted life years (DALYs), a summary measure of fatal and non-fatal disease outcomes, for over 300 diseases and injuries, for 188 countries from 1990 to the most recent year.
Journal ArticleDOI

Exacerbations of COPD

TL;DR: The importance of preventing exacerbations of COPD is highlighted, including choice of pharmacotherapy, including bronchodilators, inhaled corticosteroids, phosphodiesterase-4 inhibitors, long-term antibiotics and mucolytics.
References
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Benefits of adding fluticasone propionate/salmeterol to tiotropium in moderate to severe COPD.

TL;DR: The addition of FSC to subjects with COPD treated with TIO significantly improves lung function without increasing the risk of adverse events and this combination was superior to TIO alone in reducing rescue albuterol use.
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Statin use and exacerbations in individuals with chronic obstructive pulmonary disease.

TL;DR: Statin use was associated with reduced odds of exacerbations in individuals with COPD from the general population, although this was not apparent in those with the most severe COPD without cardiovascular comorbidity, and statins may only associate with reduced risk of exacerbation in patients with COPd with coexisting cardiovascular disease.
Journal ArticleDOI

HIV-associated obstructive lung diseases: insights and implications for the clinician

TL;DR: It is essential for clinicians to have a heightened awareness of the increased risk and manifestations of obstructive lung diseases in HIV-infected patients and specific therapeutic considerations to care for this population.
Journal ArticleDOI

Glycopyrronium once-daily significantly improves lung function and health status when combined with salmeterol/fluticasone in patients with COPD: the GLISTEN study, a randomised controlled trial.

TL;DR: GLY+SAL/FP showed comparable improvements in lung function, health status and rescue medication to TIO+Sal/FP as well as addition of GLY to SAL/FP, which demonstrated significant improvements in Lung function, Health status and Rescue medication compared to SAL /FP.
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