Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease 2017 Report: GOLD Executive Summary.
Claus Vogelmeier,Gerard J. Criner,Fernando J. Martinez,Antonio Anzueto,Peter J. Barnes,Jean Bourbeau,Bartolome R. Celli,Rongchang Chen,Marc Decramer,Leonardo M. Fabbri,Peter Frith,David M.G. Halpin,M. Victorina López Varela,Masaharu Nishimura,Nicolas Roche,Roberto Rodriguez-Roisin,Don D. Sin,Dave Singh,Robert Stockley,Jørgen Vestbo,Jadwiga A. Wedzicha,Alvar Agusti +21 more
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TLDR
The assessment of chronic obstructive pulmonary disease has been refined to separate the spirometric assessment from symptom evaluation, and the importance of comorbid conditions in managing COPD is reviewed.Abstract:
This Executive Summary of the Global Strategy for the Diagnosis, Management, and Prevention of COPD (GOLD) 2017 Report focuses primarily on the revised and novel parts of the document. The most significant changes include: 1) the assessment of chronic obstructive pulmonary disease has been refined to separate the spirometric assessment from symptom evaluation. ABCD groups are now proposed to be derived exclusively from patient symptoms and their history of exacerbations; 2) for each of the groups A to D, escalation strategies for pharmacological treatments are proposed; 3) the concept of de-escalation of therapy is introduced in the treatment assessment scheme; 4) nonpharmacologic therapies are comprehensively presented and; 5) the importance of comorbid conditions in managing COPD is reviewed.read more
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Global, regional, and national deaths, prevalence, disability-adjusted life years, and years lived with disability for chronic obstructive pulmonary disease and asthma, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015
Joan B. Soriano,Joan B. Soriano,Amanuel Alemu Abajobir,Kalkidan Hassen Abate,Semaw Ferede Abera,Anurag Agrawal,Muktar Beshir Ahmed,Amani Nidhal Aichour,Ibtihel Aichour,Miloud Taki Eddine Aichour,Khurshid Alam,Noore Alam,Juma Alkaabi,Fatma Al-Maskari,Nelson Alvis-Guzman,Alemayehu Amberbir,Yaw Ampem Amoako,Mustafa Geleto Ansha,Josep M. Antó,Hamid Asayesh,Tesfay Mehari Atey,Euripide Frinel G Arthur Avokpaho,Aleksandra Barac,Sanjay Basu,Neeraj Bedi,Isabela M. Benseñor,Adugnaw Berhane,Addisu Shunu Beyene,Addisu Shunu Beyene,Zulfiqar A Bhutta,Stan Biryukov,Dube Jara Boneya,Michael Brauer,David O. Carpenter,David O. Carpenter,Daniel C Casey,Devasahayam J. Christopher,Lalit Dandona,Rakhi Dandona,Samath D Dharmaratne,Huyen Phuc Do,Florian Fischer,TT Gebrehiwot,TT Gebrehiwot,TT Gebrehiwot,Ayele Geleto,Ayele Geleto,Ayele Geleto,Aloke Gopal Ghoshal,Richard F. Gillum,Ibrahim Abdelmageem Mohamed Ginawi,Vipin Gupta,Simon I. Hay,Mohammad Taghi Hedayati,Nobuyuki Horita,Nobuyuki Horita,H. Dean Hosgood,Mihajlo Jakovljevic,Spencer L. James,Jost B. Jonas,Amir Kasaeian,Yousef Khader,Ibrahim A Khalil,Ejaz Ahmad Khan,Young-Ho Khang,Jagdish Khubchandani,Luke D. Knibbs,Soewarta Kosen,Parvaiz A Koul,G Anil Kumar,Cheru Tesema Leshargie,Xiaofeng Liang,Hassan Magdy Abd El Razek,Azeem Majeed,Deborah Carvalho Malta,Treh Manhertz,Neal Marquez,Alem Mehari,George A. Mensah,Ted R. Miller,Karzan Abdulmuhsin Mohammad,Kedir Endris Mohammed,Shafiu Mohammed,Ali H. Mokdad,Mohsen Naghavi,Cuong Tat Nguyen,Grant Nguyen,Quyen Nguyen,Trang Huyen Nguyen,Dina Nur Anggraini Ningrum,Vuong Minh Nong,Jennifer Ifeoma Obi,Yewande E Odeyemi,Felix Akpojene Ogbo,Eyal Oren,Padukudru Anand Mahesh,Eun-Kee Park,George C Patton,Katherine R. Paulson,Mostafa Qorbani,Reginald Quansah,Anwar Rafay,Mohammad Hifz Ur Rahman,Rajesh Kumar Rai,Salman Rawaf,Nik Reinig,Saeid Safiri,Rodrigo Sarmiento-Suarez,Benn Sartorius,Miloje Savic,Monika Sawhney,Mika Shigematsu,Mari Smith,Fentaw Tadese,George D. Thurston,Roman Topor-Madry,Bach Xuan Tran,Kingsley N. Ukwaja,Job F M van Boven,Vasiliy Victorovich Vlassov,Stein Emil Vollset,Xia Wan,Andrea Werdecker,Sarah Wulf Hanson,Yuichiro Yano,Hassen Hamid Yimam,Naohiro Yonemoto,Chuanhua Yu,Zoubida Zaidi,Maysaa El Sayed Zaki,Alan D. Lopez,Christopher J L Murray,Theo Vos +132 more
TL;DR: The GBD study provides annual updates on estimates of deaths, prevalence, and disability-adjusted life years (DALYs), a summary measure of fatal and non-fatal disease outcomes, for over 300 diseases and injuries, for 188 countries from 1990 to the most recent year.
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European Respiratory Society guidelines for the management of adult bronchiectasis
Eva Polverino,Pieter Goeminne,Melissa J. McDonnell,Melissa J. McDonnell,Stefano Aliberti,Sara E. Marshall,Michael R. Loebinger,Marlene Murris,Rafael Cantón,Antoni Torres,Katerina Dimakou,Anthony De Soyza,Anthony De Soyza,Adam T. Hill,Charles S. Haworth,Montserrat Vendrell,Felix C. Ringshausen,Dragan Subotic,Robert Wilson,Jordi Vilaró,Björn Ställberg,Tobias Welte,Gernot Rohde,Francesco Blasi,Stuart Elborn,Stuart Elborn,Marta Almagro,Alan Timothy,Thomas Ruddy,Thomy Tonia,David Rigau,James D. Chalmers +31 more
TL;DR: The ERS guidelines for the management of adult bronchiectasis describe the appropriate investigation and treatment strategies determined by a systematic review of the literature, using the GRADE approach to define the quality of the evidence and the level of recommendations.
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Management of COPD exacerbations: a European Respiratory Society/American Thoracic Society guideline
Jadwiga A. Wedzicha,Marc Miravitlles,John R. Hurst,Peter M.A. Calverley,Richard K. Albert,Antonio Anzueto,Gerard J. Criner,Alberto Papi,Klaus F. Rabe,David Rigau,Pawel Sliwinski,Thomy Tonia,Jørgen Vestbo,Kevin C. Wilson,Jerry A. Krishnan +14 more
TL;DR: The Task Force providedRecommendations related to corticosteroid therapy, antibiotic therapy, noninvasive mechanical ventilation, home-based management, and early pulmonary rehabilitation in patients having a COPD exacerbation should be reconsidered as new evidence becomes available.
Journal ArticleDOI
Activated PMN Exosomes: Pathogenic Entities Causing Matrix Destruction and Disease in the Lung.
Kristopher R. Genschmer,Derek W Russell,Charitharth Vivek Lal,Tomasz Szul,Preston E. Bratcher,Brett D. Noerager,Mojtaba Abdul Roda,Xin Xu,Gabriel Rezonzew,Liliana Viera,Brian S. Dobosh,Camilla Margaroli,Tarek Abdalla,Robert W. King,Carmel M. McNicholas,J. Michael Wells,Mark T. Dransfield,Rabindra Tirouvanziam,Amit Gaggar,J. Edwin Blalock +19 more
TL;DR: Findings reveal an unappreciated role for exosomes in the pathogenesis of disorders of ECM homeostasis such as COPD and BPD, providing a critical mechanism for proteolytic damage.
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Exacerbations of COPD
C. Viniol,Claus Vogelmeier +1 more
TL;DR: The importance of preventing exacerbations of COPD is highlighted, including choice of pharmacotherapy, including bronchodilators, inhaled corticosteroids, phosphodiesterase-4 inhibitors, long-term antibiotics and mucolytics.
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