Journal ArticleDOI
Grape seed proanthocyanidin extract ameliorates inflammation and adiposity by modulating gut microbiota in high-fat diet mice
Wen Liu,Shaoqian Zhao,Jiqiu Wang,Juan Shi,Yingkai Sun,Weiqing Wang,Guang Ning,Jie Hong,Ruixin Liu +8 more
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TLDR
The novel links between gut microbiota alterations and metabolic benefits by G SPE supplementation are identified, providing possibilities for the prevention and treatment of metabolic disorders by targeting gut microbiota through a potential prebiotic agent GSPE.Abstract:
cope
: Obesity and associated metabolic complications is a worldwide public health issue. Gut microbiota has been recently linked to obesity and its related inflammation. In this study, we have explored the anti-inflammatory effect of grape seed proanthocyanindin extract (GSPE) in the high-fat diet (HFD)-induced obesity and identified the contribution of the gut microbiota to GSPE effects on metabolism.
Methods and results
: Mice were fed a normal diet and a high-fat diet with or without GSPE (300mg/kg body weight/day) by oral gavage for 7 weeks. Supplementation with GSPE significantly decreased plasma levels of inflammatory factors such as TNF-α, IL-6 and MCP-1, companied with ameliorated macrophage infiltration in epidydimal fat and liver tissues. Furthermore, GSPE also reduced epidydimal fat mass and improved insulin sensitivity. 16S rDNA analyses revealed that GSPE supplementation modulated the gut microbiota composition and certain bacteria including Clostridium XIVa, Roseburia and Prevotella. More importantly, depleting gut microbiota by antibiotics treatment abolished the beneficial effects of GSPE on inflammation and adiposity.
Conclusions
: Our study identifies the novel links between gut microbiota alterations and metabolic benefits by GSPE supplementation, providing possibilities for the prevention and treatment of metabolic disorders by targeting gut microbiota through a potential prebiotic agent GSPE.
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Journal ArticleDOI
Balancing Herbal Medicine and Functional Food for Prevention and Treatment of Cardiometabolic Diseases through Modulating Gut Microbiota.
TL;DR: A balance between herbal medicine and functional food rich in fiber, polyphenols and polysaccharides plays a vital role in modulating gut microbiota through SCFAs, BAs, LPS and TMAO signaling regarding CMDs.
Journal ArticleDOI
Proanthocyanidins in grape seeds: An updated review of their health benefits and potential uses in the food industry
TL;DR: The current literature regarding grape seed proanthocyanidins is summarized, focusing on the recently proposed mechanisms of action from clinical trials considered to underlie pharmacological and disease-preventing properties, along with their bioavailability, toxicology, and safety with regard to potential utilization in the food industry.
Journal ArticleDOI
Reduced obesity, diabetes and steatosis upon cinnamon and grape pomace are associated with changes in gut microbiota and markers of gut barrier
Matthias Van Hul,Lucie Geurts,Hubert Plovier,Céline Druart,Amandine Everard,Marcus Ståhlman,Moez Rhimi,Kleopatra Chira,Kleopatra Chira,Pierre-Louis Teissedre,Pierre-Louis Teissedre,Nathalie M. Delzenne,Emmanuelle Maguin,Angèle Guilbot,Amandine Brochot,Philippe Gérard,Fredrik Bäckhed,Fredrik Bäckhed,Patrice D. Cani +18 more
TL;DR: The data suggest that CBE and GPE can ameliorate the overall metabolic profile of mice on a high-fat diet, partly by acting on the gut microbiota.
Journal ArticleDOI
Sulfated Polysaccharide from Sea Cucumber and its Depolymerized Derivative Prevent Obesity in Association with Modification of Gut Microbiota in High-Fat Diet-Fed Mice
Zhenjun Zhu,Zhenjun Zhu,Beiwei Zhu,Beiwei Zhu,Yujiao Sun,Yujiao Sun,Chunqing Ai,Lilong Wang,Chengrong Wen,Jingfeng Yang,Shuang Song,Shuang Song,Xiaoling Liu +12 more
TL;DR: It is suggested that SCSP can prevent diet-induced obesity and its associated diseases by modulating the gut microbiota and improving microbial metabolites and gut tissue, and its effects can be enhanced by free-radical depolymerization.
Journal ArticleDOI
Beneficial Effects of Dietary Polyphenols on High-Fat Diet-Induced Obesity Linking with Modulation of Gut Microbiota.
TL;DR: The present review summarizes the findings of recent studies on dietary polyphenols regarding their metabolism and interaction with bacteria in the intestine as well as the underlying mechanisms by which they modulate the gut microbiota and alleviate the HFD-induced obesity.
References
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TL;DR: In this paper, the authors compared the fecal microbiota of European children (EU) and that of children from a rural African village of Burkina Faso (BF), where the diet, high in fiber content, is similar to that of early human settlements at the time of the birth of agriculture.
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