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Guide for the Care and Use of Laboratory Animals
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The article was published on 1996-02-01 and is currently open access. It has received 13908 citations till now. The article focuses on the topics: Animal Care Committees & Laboratory Animal Science.read more
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Pain and Laboratory Animals: Publication Practices for Better Data Reproducibility and Better Animal Welfare.
Larry Carbone,Jamie Austin +1 more
TL;DR: Current scientific literature cannot be trusted to present full detail on use of animal anesthetics and analgesics, and it is suggested that journals, scientists and animal welfare regulators should revise current guidelines and regulations, on treatment of pain and on transparent reporting of treatment ofPain, to improve this dual welfare and data-quality deficiency.
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Correlation of brain magnetic resonance imaging changes with pallidal manganese concentrations in rhesus monkeys following subchronic manganese inhalation
TL;DR: This first comprehensive study to use MRI, pallidal index (PI), and T(1) relaxation rate (R1) in concert with chemical analysis to establish a direct association between MRI changes and pallidal manganese concentration in rhesus monkeys following subchronic inhalation ofManganese sulfate is presented.
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Anti-Inflammatory Mechanism of Compound K in Activated Microglia and Its Neuroprotective Effect on Experimental Stroke in Mice
Jin Sun Park,Jin A. Shin,Ji Sun Jung,Jin Won Hyun,Thi Kim Van Le,Dong-Hyun Kim,Eun Mi Park,Hee Sun Kim +7 more
TL;DR: Compound K reduced the infarct volume of ischemic brain induced by middle cerebral artery occlusion and suppressed microglial activation in the isChemic cortex, suggesting that compound K is a promising agent for prevention and/or treatment of cerebral ischemia and other neuroinflammatory disorders.
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Ebola Hemorrhagic Fever: Evaluation of Passive Immunotherapy in Nonhuman Primates
TL;DR: Although passively acquired antibody titers comparable to those associated with effective vaccination were obtained, all monkeys that had received transfusions succumbed to infection concurrently with control monkeys, casting further doubt on the value of passive immunotherapy for the treatment of EBOV infection.
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Pharmacokinetics, pharmacodynamics, metabolism, distribution, and excretion of carfilzomib in rats.
Jinfu Yang,Zhengping Wang,Ying Fang,Jing Jiang,Frances Zhao,Hansen Wong,Mark K. Bennett,Christopher J. Molineaux,Christopher J. Kirk +8 more
TL;DR: Despite the high systemic clearance, potent proteasome inhibition was observed in blood and a variety of tissues and together with rapid and irreversible target binding, the high clearance may provide an advantage in that “unnecessary” exposure to the drug is minimized and potential drug-related side effects may be reduced.
References
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Oxidants, antioxidants, and the degenerative diseases of aging
TL;DR: It is argued that this damage to DNA, protein, and lipid is a major contributor to aging and to degenerative diseases of aging such as cancer, cardiovascular disease, immune-system decline, brain dysfunction, and cataracts.
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Guide for the Care and Use of Laboratory Animals
TL;DR: The Guide for the Care and Use of Laboratory Animals by the Institute for Laboratory Animal Research (ILAR) of the National Research Council in the USA, is well known among most individuals involved in laboratory animal care and use and the overall intention is to support the readers to build a programme which creates a system of selfregulation and regulatory oversight.