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Guide for the Care and Use of Laboratory Animals
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The article was published on 1996-02-01 and is currently open access. It has received 13908 citations till now. The article focuses on the topics: Animal Care Committees & Laboratory Animal Science.read more
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Benefits of positive human interaction for socially- housed chimpanzees
TL;DR: The results suggest that simple, unstructured affiliation between humans and chimpanzees should be a valued component of behavioural management.
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Rac1 links leading edge and uropod events through Rho and myosin activation during chemotaxis
Kersi Pestonjamasp,Carol Forster,Carol Forster,Carol Forster,Chunxiang Sun,Chunxiang Sun,Chunxiang Sun,Elisabeth Gardiner,Elisabeth Gardiner,Elisabeth Gardiner,Ben Bohl,Ben Bohl,Ben Bohl,Orion D. Weiner,Orion D. Weiner,Orion D. Weiner,Gary M. Bokoch,Gary M. Bokoch,Gary M. Bokoch,Michael Glogauer,Michael Glogauer,Michael Glogauer +21 more
TL;DR: It is demonstrated here that Rac1 (and not Rac2) is essential for Rho and myosin activation at the trailing edge to regulate uropod function, thereby promoting stable polarity in chemotaxing neutrophils.
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Prelimbic to Accumbens Core Pathway Is Recruited in a Dopamine-Dependent Manner to Drive Cued Reinstatement of Cocaine Seeking.
TL;DR: Prelimbic cortex projections to nucleus accumbens core (NAcC) uniquely expressed Fos in a manner that positively correlated with cocaine- seeking, but not sucrose-seeking, behavior, which highlights PL neurons that project to NAcC, and their regulation by dopamine, as potential targets for therapeutics to treat cocaine relapse that do not affect natural reward seeking.
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Developmental neurotoxicity study of dietary bisphenol A in Sprague-Dawley rats.
Donald G. Stump,Melissa J. Beck,Ann Radovsky,Robert H. Garman,Lester L. Freshwater,Larry P. Sheets,M. Sue Marty,John M. Waechter,Stephen Dimond,John P. Van Miller,Ronald N. Shiotsuka,Dieter Beyer,Anne H. Chappelle,Steven G. Hentges +13 more
TL;DR: For F1 offspring, there was no evidence that BPA is a developmental neurotoxicant in rats, and the NOAEL for developmental neurotoxicity was 2250 ppm, the highest dose tested.
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Propolis prevents aluminium-induced genetic and hepatic damages in rat liver
TL;DR: It can be concluded that propolis has beneficial influences and could be able to antagonize AlCl(3) toxicity.
References
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Oxidants, antioxidants, and the degenerative diseases of aging
TL;DR: It is argued that this damage to DNA, protein, and lipid is a major contributor to aging and to degenerative diseases of aging such as cancer, cardiovascular disease, immune-system decline, brain dysfunction, and cataracts.
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Guide for the Care and Use of Laboratory Animals
TL;DR: The Guide for the Care and Use of Laboratory Animals by the Institute for Laboratory Animal Research (ILAR) of the National Research Council in the USA, is well known among most individuals involved in laboratory animal care and use and the overall intention is to support the readers to build a programme which creates a system of selfregulation and regulatory oversight.