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Guide for the Care and Use of Laboratory Animals
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The article was published on 1996-02-01 and is currently open access. It has received 13908 citations till now. The article focuses on the topics: Animal Care Committees & Laboratory Animal Science.read more
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Postconditioning's protection is not dependent on circulating blood factors or cells but involves adenosine receptors and requires PI3-kinase and guanylyl cyclase activation.
TL;DR: Postconditioning’s protection is not dependent on circulating blood factors or cells, and its anti–infarct effect appears to require PI3–kinase activation, stimulation of guanylyl cyclase and occupancy of adenosine receptors.
Journal ArticleDOI
The cluster 1 type VI secretion system is a major virulence determinant in Burkholderia pseudomallei.
Mary N. Burtnick,Paul J. Brett,Sarah V. Harding,Sarah A. Ngugi,Wilson J. Ribot,Narisara Chantratita,Angelo Scorpio,Timothy S. Milne,Rachel E. Dean,David L. Fritz,Sharon J. Peacock,Joanne Lisa Prior,Timothy P. Atkins,David DeShazer +13 more
TL;DR: The results suggest that the cluster 1 T6SS is essential for virulence and plays an important role in the intracellular lifestyle of B. pseudomallei.
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Preclinical Assessment of Candidate Analgesic Drugs: Recent Advances and Future Challenges
S. Stevens Negus,Todd W. Vanderah,Michael R. Brandt,Edward J. Bilsky,Lino Becerra,David Borsook +5 more
TL;DR: Integration of these complementary approaches may improve the predictive validity of analgesic drug development and provide new insights into the behavioral consequences of pain and the effects of candidate analgesics.
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Quantitative changes in gene expression in fetal rat testes following exposure to di(n-butyl) phthalate.
Norman J. Barlow,Suzanne L. Phillips,Duncan G. Wallace,Madhabananda Sar,Kevin W. Gaido,Paul M. D. Foster +5 more
TL;DR: Downregulation of most of the genes in the T biosynthetic pathway confirms and extends previous findings and supports altered cholesterol metabolism and transport as a potential mechanism for decreased T synthesis following exposure to DBP.
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Programming of glucose-insulin metabolism in adult sheep after maternal undernutrition
David S. Gardner,K. J. Tingey,B. W. M. Van Bon,Susan E. Ozanne,V Wilson,J. Dandrea,Duane H. Keisler,Terence Stephenson,Michael E. Symonds +8 more
TL;DR: Pregnant undernutrition, specifically during late gestation, affects adult offspring intermediary metabolism, and, in particular, glucose-insulin homeostasis in sheep, which was unaffected by fetal number.
References
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Oxidants, antioxidants, and the degenerative diseases of aging
TL;DR: It is argued that this damage to DNA, protein, and lipid is a major contributor to aging and to degenerative diseases of aging such as cancer, cardiovascular disease, immune-system decline, brain dysfunction, and cataracts.
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Guide for the Care and Use of Laboratory Animals
TL;DR: The Guide for the Care and Use of Laboratory Animals by the Institute for Laboratory Animal Research (ILAR) of the National Research Council in the USA, is well known among most individuals involved in laboratory animal care and use and the overall intention is to support the readers to build a programme which creates a system of selfregulation and regulatory oversight.