Gut Akkermansia muciniphila ameliorates metabolic dysfunction-associated fatty liver disease by regulating the metabolism of L-aspartate via gut-liver axis.
Yong Rao,Zhi-qi Kuang,Chan Li,Shi-Yao Guo,Yao-Hao Xu,Dan-Dan Zhao,Yu-Tao Hu,Bing-Bing Song,Zhi Jiang,Zhen-Huang Ge,Xi-Yuan Liu,Cheng-Dao Li,Shuo-Bin Chen,Ji-Ming Ye,Zhi-Shu Huang,Yongjun Lu +15 more
Reads0
Chats0
TLDR
Akkermansia muciniphila has been increasingly recognized for its therapeutic potential in treating metabolic disorders, including obesity, diabetes, and metabolicdysfunction-association as discussed by the authors.Abstract:
The gut bacterium Akkermansia muciniphila has been increasingly recognized for its therapeutic potential in treating metabolic disorders, including obesity, diabetes, and metabolicdysfunction-assoc...read more
Citations
More filters
Journal ArticleDOI
Akkermansia muciniphila ameliorates chronic kidney disease interstitial fibrosis via the gut-renal axis.
Tingting Pei,Rong Hu,Fujing Wang,Sixia Yang,Haitong Feng,Qiye Li,Jiaxing Zhang,Shihua Yan,Liliang Ju,Zhu He,Zhongxiao Han,Aicheng Yang,Wei Xiao,Ma Yun,Ming Wang +14 more
TL;DR: In this article , Akkermansia muciniphila (AKK) was used to treat chronic kidney disease (CKD) in 5/6 nephrectomy rats.
Journal ArticleDOI
Interventions for non-alcoholic liver disease: a gut microbial metabolites perspective
Jin Guo,Chun-xia Shi,Qing-Qi Zhang,Wei Deng,Luyi Zhang,Qian Chen,Dan-Mei Zhang,Zuojiong Gong +7 more
TL;DR: In this paper , the interaction of microbial products and non-alcoholic fatty liver disease (NAFLD) has been explored, and the regulatory role of existing NAFLD therapies on metabolite levels was discussed.
Journal ArticleDOI
Role of Akkermansia muciniphila in the development of nonalcoholic fatty liver disease: current knowledge and perspectives
Journal ArticleDOI
Pectin in Metabolic Liver Disease
TL;DR: In this paper , the role of a soluble fiber, pectin, in reducing the development of liver injury in NAFLD and ALD through its impact on gut bacteria.
Journal ArticleDOI
Akkermansia muciniphila and Bifidobacterium bifidum Prevent NAFLD by Regulating FXR Expression and Gut Microbiota
TL;DR: In this article , Akkermansia muciniphila and Bifidobacterium bifidum alone or in combination was shown to prevent NAFLD in mice.
References
More filters
Journal ArticleDOI
Trimmomatic: a flexible trimmer for Illumina sequence data
TL;DR: Timmomatic is developed as a more flexible and efficient preprocessing tool, which could correctly handle paired-end data and is shown to produce output that is at least competitive with, and in many cases superior to, that produced by other tools, in all scenarios tested.
Journal ArticleDOI
Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity
Amandine Everard,Clara Belzer,Lucie Geurts,Janneke P. Ouwerkerk,Céline Druart,Laure B. Bindels,Yves Guiot,Muriel Derrien,Giulio G. Muccioli,Nathalie M. Delzenne,Willem M. de Vos,Willem M. de Vos,Patrice D. Cani +12 more
TL;DR: Substantial insight is provided into the intricate mechanisms of bacterial regulation of the cross-talk between the host and gut microbiota and provides a rationale for the development of a treatment that uses this human mucus colonizer for the prevention or treatment of obesity and its associated metabolic disorders.
Journal ArticleDOI
Mechanisms of NAFLD development and therapeutic strategies
TL;DR: Understanding of pathogenic mechanisms and clinical features of NAFLD is driving progress in therapeutic strategies now in clinical trials and the emerging targets for drug development that involve either single agents or combination therapies intended to arrest or reverse disease progression are discussed.
Journal ArticleDOI
Animal Research: Reporting in vivo Experiments—The ARRIVE Guidelines:
TL;DR: The following guidelines are excerpted (as permitted under the Creative Commons Attribution License (CCAL), with the knowledge and approval of PLoS Biology and the authors) from Kilkenny et al.
Journal ArticleDOI
NAFLD: A multisystem disease
TL;DR: A narrative review focuses on the rapidly expanding body of clinical evidence that supports the concept of NAFLD as a multisystem disease and the factors linkingNAFLD with other extra-hepatic chronic diseases, such as T2DM, CVD, cardiac diseases and CKD.
Related Papers (5)
Dietary betaine prevents obesity through gut microbiota-drived microRNA-378a family.
Jingjing Du,Peiwen Zhang,Jiang Luo,Linyuan Shen,Shunhua Zhang,Hao Gu,Jin He,Linghui Wang,Xue Zhao,Mailing Gan,Liu Yang,Lili Niu,Ye Zhao,Qianzi Tang,Guoqing Tang,Dongmei Jiang,Yanzhi Jiang,Mingzhou Li,Anan Jiang,Long Jin,Jideng Ma,Surong Shuai,Lin Bai,Jinyong Wang,Bo Zeng,De Wu,Xuewei Li,Li Zhu +27 more