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Open AccessJournal ArticleDOI

Gut Akkermansia muciniphila ameliorates metabolic dysfunction-associated fatty liver disease by regulating the metabolism of L-aspartate via gut-liver axis.

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TLDR
Akkermansia muciniphila has been increasingly recognized for its therapeutic potential in treating metabolic disorders, including obesity, diabetes, and metabolicdysfunction-association as discussed by the authors.
Abstract
The gut bacterium Akkermansia muciniphila has been increasingly recognized for its therapeutic potential in treating metabolic disorders, including obesity, diabetes, and metabolicdysfunction-assoc...

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Gut Microbial Alterations in Diarrheal Baer's Pochards (Aythya baeri).

TL;DR: In this paper, the authors performed high-throughput sequencing of the fungal-specific internal transcribed spacer 1 (ITS-1) to detect the differences of gut mycobiota in healthy and diarrheal Baer's pochard.
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<i>Akkermansia muciniphila</i> plays critical roles in host health

TL;DR: A. muciniphila, an intestinal microorganism, belongs to Verrucomicrobia, one of the most abundant microorganisms in the mammalian gut as discussed by the authors , is a mucin-degrading bacterium that can colonise intestines of mammals such as humans and mice by utilising mucin as the only nitrogen and carbon source.
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Integrated Analysis of the Alterations in Gut Microbiota and Metabolites of Mice Induced After Long-Term Intervention With Different Antibiotics

TL;DR: It is shown that the antibiotic-induced alterations in gut microbiota contribute to host inflammatory responses through the change in metabolic status, which is likely related to the type, rather than timing of antibiotic used.
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Depletion of Gut Microbiota Inhibits Hepatic Lipid Accumulation in High-Fat Diet-Fed Mice

TL;DR: Gut microbiota ameliorates HFD-induced hepatic lipid metabolic dysfunction, which might be associated with genes participating in cholesterol and fatty acid metabolism in the liver.
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Bacteroides plebeius improves muscle wasting in chronic kidney disease by modulating the gut‐renal muscle axis

TL;DR: In this paper , the effects of Bacteroides plebeius on protein energy consumption in rats with chronic renal failure (CKD) were investigated, and the results suggest that Bactoeides Plebeius may combat muscle atrophy through the Mystn/ActRIIB/SMAD2 pathway.
References
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Journal ArticleDOI

Trimmomatic: a flexible trimmer for Illumina sequence data

TL;DR: Timmomatic is developed as a more flexible and efficient preprocessing tool, which could correctly handle paired-end data and is shown to produce output that is at least competitive with, and in many cases superior to, that produced by other tools, in all scenarios tested.
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Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity

TL;DR: Substantial insight is provided into the intricate mechanisms of bacterial regulation of the cross-talk between the host and gut microbiota and provides a rationale for the development of a treatment that uses this human mucus colonizer for the prevention or treatment of obesity and its associated metabolic disorders.
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Mechanisms of NAFLD development and therapeutic strategies

TL;DR: Understanding of pathogenic mechanisms and clinical features of NAFLD is driving progress in therapeutic strategies now in clinical trials and the emerging targets for drug development that involve either single agents or combination therapies intended to arrest or reverse disease progression are discussed.
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Animal Research: Reporting in vivo Experiments—The ARRIVE Guidelines:

TL;DR: The following guidelines are excerpted (as permitted under the Creative Commons Attribution License (CCAL), with the knowledge and approval of PLoS Biology and the authors) from Kilkenny et al.
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NAFLD: A multisystem disease

TL;DR: A narrative review focuses on the rapidly expanding body of clinical evidence that supports the concept of NAFLD as a multisystem disease and the factors linkingNAFLD with other extra-hepatic chronic diseases, such as T2DM, CVD, cardiac diseases and CKD.
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