Gut Akkermansia muciniphila ameliorates metabolic dysfunction-associated fatty liver disease by regulating the metabolism of L-aspartate via gut-liver axis.
Yong Rao,Zhi-qi Kuang,Chan Li,Shi-Yao Guo,Yao-Hao Xu,Dan-Dan Zhao,Yu-Tao Hu,Bing-Bing Song,Zhi Jiang,Zhen-Huang Ge,Xi-Yuan Liu,Cheng-Dao Li,Shuo-Bin Chen,Ji-Ming Ye,Zhi-Shu Huang,Yongjun Lu +15 more
Reads0
Chats0
TLDR
Akkermansia muciniphila has been increasingly recognized for its therapeutic potential in treating metabolic disorders, including obesity, diabetes, and metabolicdysfunction-association as discussed by the authors.Abstract:
The gut bacterium Akkermansia muciniphila has been increasingly recognized for its therapeutic potential in treating metabolic disorders, including obesity, diabetes, and metabolicdysfunction-assoc...read more
Citations
More filters
Journal ArticleDOI
Utility of Human Relevant Preclinical Animal Models in Navigating NAFLD to MAFLD Paradigm
TL;DR: In this paper , the authors provided an updated evaluation of existing metabolic dysfunction-associated fatty liver disease (MAFLD) preclinical models in alignment with the new definitions and perspectives to improve their translational relevance.
Journal ArticleDOI
Microbial-Driven Immunological Memory and Its Potential Role in Microbiome Editing for the Prevention of Colorectal Cancer
Laure Campillo-Gimenez,David Rios-Covian,Jesus Rivera-Nieves,Jesus Rivera-Nieves,Hiroshi Kiyono,Hiroshi Kiyono,Hiutung Chu,Peter B. Ernst +7 more
TL;DR: A review of the role of bacteria in the pathogenesis of colorectal cancer can be found in this article, where the authors raise questions about how immune memory responses to the local microbial consortium affect any attempt to modify the composition of the intestinal microbiome.
Journal ArticleDOI
Indole-3-propionic acid alleviates sepsis-associated acute liver injury by activating pregnane X receptor
Shuangyao Wang,Liangzhi Xiong,Zhihua Ruan,Xiaofang Gong,Yanrong Luo,Cheng Wu,Yu Wang,Huijuan Shang,Jingyi Chen +8 more
TL;DR: Wang et al. as discussed by the authors explored the association between indole-3-propionic acid (IPA) and acute liver injury (SALI), and showed that the level of IPA in patients' feces is closely related to SALI.
Journal ArticleDOI
Lingguizhugan Decoction Targets Intestinal Microbiota and Metabolites to Reduce Insulin Resistance in High-Fat Diet Rats
TL;DR: It is shown that LGZGD relieved IR, possibly by regulating the composition of the fecal microbiota and its metabolites, and metabolites developed toward the healthy control group.
Journal ArticleDOI
Brain-gut-liver axis: Chronic psychological stress promotes liver injury and fibrosis via gut in rats
TL;DR: In this article , the effect and mechanism of chronic psychological stress in promoting liver injury and fibrosis through gut was investigated, and the authors found significant differences in rats among each group.
References
More filters
Journal ArticleDOI
Trimmomatic: a flexible trimmer for Illumina sequence data
TL;DR: Timmomatic is developed as a more flexible and efficient preprocessing tool, which could correctly handle paired-end data and is shown to produce output that is at least competitive with, and in many cases superior to, that produced by other tools, in all scenarios tested.
Journal ArticleDOI
Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity
Amandine Everard,Clara Belzer,Lucie Geurts,Janneke P. Ouwerkerk,Céline Druart,Laure B. Bindels,Yves Guiot,Muriel Derrien,Giulio G. Muccioli,Nathalie M. Delzenne,Willem M. de Vos,Willem M. de Vos,Patrice D. Cani +12 more
TL;DR: Substantial insight is provided into the intricate mechanisms of bacterial regulation of the cross-talk between the host and gut microbiota and provides a rationale for the development of a treatment that uses this human mucus colonizer for the prevention or treatment of obesity and its associated metabolic disorders.
Journal ArticleDOI
Mechanisms of NAFLD development and therapeutic strategies
TL;DR: Understanding of pathogenic mechanisms and clinical features of NAFLD is driving progress in therapeutic strategies now in clinical trials and the emerging targets for drug development that involve either single agents or combination therapies intended to arrest or reverse disease progression are discussed.
Journal ArticleDOI
Animal Research: Reporting in vivo Experiments—The ARRIVE Guidelines:
TL;DR: The following guidelines are excerpted (as permitted under the Creative Commons Attribution License (CCAL), with the knowledge and approval of PLoS Biology and the authors) from Kilkenny et al.
Journal ArticleDOI
NAFLD: A multisystem disease
TL;DR: A narrative review focuses on the rapidly expanding body of clinical evidence that supports the concept of NAFLD as a multisystem disease and the factors linkingNAFLD with other extra-hepatic chronic diseases, such as T2DM, CVD, cardiac diseases and CKD.
Related Papers (5)
Dietary betaine prevents obesity through gut microbiota-drived microRNA-378a family.
Jingjing Du,Peiwen Zhang,Jiang Luo,Linyuan Shen,Shunhua Zhang,Hao Gu,Jin He,Linghui Wang,Xue Zhao,Mailing Gan,Liu Yang,Lili Niu,Ye Zhao,Qianzi Tang,Guoqing Tang,Dongmei Jiang,Yanzhi Jiang,Mingzhou Li,Anan Jiang,Long Jin,Jideng Ma,Surong Shuai,Lin Bai,Jinyong Wang,Bo Zeng,De Wu,Xuewei Li,Li Zhu +27 more