Gut Akkermansia muciniphila ameliorates metabolic dysfunction-associated fatty liver disease by regulating the metabolism of L-aspartate via gut-liver axis.
Yong Rao,Zhi-qi Kuang,Chan Li,Shi-Yao Guo,Yao-Hao Xu,Dan-Dan Zhao,Yu-Tao Hu,Bing-Bing Song,Zhi Jiang,Zhen-Huang Ge,Xi-Yuan Liu,Cheng-Dao Li,Shuo-Bin Chen,Ji-Ming Ye,Zhi-Shu Huang,Yongjun Lu +15 more
Reads0
Chats0
TLDR
Akkermansia muciniphila has been increasingly recognized for its therapeutic potential in treating metabolic disorders, including obesity, diabetes, and metabolicdysfunction-association as discussed by the authors.Abstract:
The gut bacterium Akkermansia muciniphila has been increasingly recognized for its therapeutic potential in treating metabolic disorders, including obesity, diabetes, and metabolicdysfunction-assoc...read more
Citations
More filters
Journal ArticleDOI
Multiomics Study Reveals Enterococcus and Subdoligranulum Are Beneficial to Necrotizing Enterocolitis
Hao Lin,Hao Lin,Qingqing Guo,Yun Ran,Lijian Lin,Pengcheng Chen,Jianquan He,Ye Chen,Jianbo Wen +8 more
TL;DR: Wang et al. as discussed by the authors found that the combination of FMT and Sulperazone significantly prolonged the survival of NEC rabbits, and they made a conclusion that the Enterococcus and Subdoligranulum benefits NEC by influencing the bacterial phages and butyrate production.
Journal ArticleDOI
Longitudinal 16S rRNA Sequencing Reveals Relationships among Alterations of Gut Microbiota and Nonalcoholic Fatty Liver Disease Progression in Mice
Aoxiang Zhuge,Shengjie Li,Pengcheng Lou,Wenrui Wu,Kaicen Wang,Yin Yuan,Jiafeng Xia,Bo Li,Lanjuan Li +8 more
TL;DR: The longitudinal alternations of gut microbiota in the Western diet induced murine NAFLD model using 16S rRNA sequencing demonstrate that a core set of gut microbiome especially BA-related taxa may be adopted as a noninvasive diagnostic tool forNAFLD and NASH.
Journal ArticleDOI
Daily Dose of Bovine Lactoferrin Prevents Ethanol-Induced Liver Injury and Death in Male Mice by Regulating Hepatic Alcohol Metabolism and Modulating Gut Microbiota.
Deming Li,Qian He,Huan-Huan Yang,Yafang Du,Kangqing Yu,Jing Yang,Xing Tong,Ya-Xin Guo,Jia-Ying Xu,Li-Qiang Qin +9 more
TL;DR: Wang et al. as mentioned in this paper showed that Lactoferrin (Lf) has a protective potential to liver, but whether it can prevent alcoholic liver injury (ALI) remains unclear.
Journal ArticleDOI
Reconsidering Meat Intake and Human Health: a Review of Current Research.
TL;DR: A review of recent advances in understanding the effects of meat or processed meat on human health, as well as the underlying mechanisms, is presented in this article , where the authors conclude that, as long as excessive intake and overprocessing of meats are avoided, meat remains an indispensable source of nutrition for human health.
Journal ArticleDOI
Gut Microbiota Ecosystem Governance of Host Inflammation, Mitochondrial Respiration and Skeletal Homeostasis
TL;DR: In this paper , the authors provide molecular and cellular insights into the biological significance of Gut microorganisms and primary and secondary metabolites important to cartilage and bone integrity, and highlight treatment options with probiotics or metabolites for modulating the progression of these two common skeletal disorders.
References
More filters
Journal ArticleDOI
Trimmomatic: a flexible trimmer for Illumina sequence data
TL;DR: Timmomatic is developed as a more flexible and efficient preprocessing tool, which could correctly handle paired-end data and is shown to produce output that is at least competitive with, and in many cases superior to, that produced by other tools, in all scenarios tested.
Journal ArticleDOI
Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity
Amandine Everard,Clara Belzer,Lucie Geurts,Janneke P. Ouwerkerk,Céline Druart,Laure B. Bindels,Yves Guiot,Muriel Derrien,Giulio G. Muccioli,Nathalie M. Delzenne,Willem M. de Vos,Willem M. de Vos,Patrice D. Cani +12 more
TL;DR: Substantial insight is provided into the intricate mechanisms of bacterial regulation of the cross-talk between the host and gut microbiota and provides a rationale for the development of a treatment that uses this human mucus colonizer for the prevention or treatment of obesity and its associated metabolic disorders.
Journal ArticleDOI
Mechanisms of NAFLD development and therapeutic strategies
TL;DR: Understanding of pathogenic mechanisms and clinical features of NAFLD is driving progress in therapeutic strategies now in clinical trials and the emerging targets for drug development that involve either single agents or combination therapies intended to arrest or reverse disease progression are discussed.
Journal ArticleDOI
Animal Research: Reporting in vivo Experiments—The ARRIVE Guidelines:
TL;DR: The following guidelines are excerpted (as permitted under the Creative Commons Attribution License (CCAL), with the knowledge and approval of PLoS Biology and the authors) from Kilkenny et al.
Journal ArticleDOI
NAFLD: A multisystem disease
TL;DR: A narrative review focuses on the rapidly expanding body of clinical evidence that supports the concept of NAFLD as a multisystem disease and the factors linkingNAFLD with other extra-hepatic chronic diseases, such as T2DM, CVD, cardiac diseases and CKD.
Related Papers (5)
Dietary betaine prevents obesity through gut microbiota-drived microRNA-378a family.
Jingjing Du,Peiwen Zhang,Jiang Luo,Linyuan Shen,Shunhua Zhang,Hao Gu,Jin He,Linghui Wang,Xue Zhao,Mailing Gan,Liu Yang,Lili Niu,Ye Zhao,Qianzi Tang,Guoqing Tang,Dongmei Jiang,Yanzhi Jiang,Mingzhou Li,Anan Jiang,Long Jin,Jideng Ma,Surong Shuai,Lin Bai,Jinyong Wang,Bo Zeng,De Wu,Xuewei Li,Li Zhu +27 more