Dietary lipids, gut microbiota and lipid metabolism
Marc Schoeler,Robert Caesar +1 more
Reads0
Chats0
TLDR
The association between gut microbiota, dietary lipids and lipid metabolism is reviewed and metabolites produced by the gut microbiota such as short-chain fatty acids, secondary bile acids and trimethylamine are reviewed.Abstract:
The gut microbiota is a central regulator of host metabolism. The composition and function of the gut microbiota is dynamic and affected by diet properties such as the amount and composition of lipids. Hence, dietary lipids may influence host physiology through interaction with the gut microbiota. Lipids affect the gut microbiota both as substrates for bacterial metabolic processes, and by inhibiting bacterial growth by toxic influence. The gut microbiota has been shown to affect lipid metabolism and lipid levels in blood and tissues, both in mice and humans. Furthermore, diseases linked to dyslipidemia, such as non-alcoholic liver disease and atherosclerosis, are associated with changes in gut microbiota profile. The influence of the gut microbiota on host lipid metabolism may be mediated through metabolites produced by the gut microbiota such as short-chain fatty acids, secondary bile acids and trimethylamine and by pro-inflammatory bacterially derived factors such as lipopolysaccharide. Here we will review the association between gut microbiota, dietary lipids and lipid metabolismread more
Citations
More filters
Journal ArticleDOI
Preventive Cardiology AbstractsChronic infections and the risk of carotid atherosclerosis. Prospective results from a large population study
S Kiechel,G Egger,M Mayr +2 more
TL;DR: Markers of systemic inflammation, such as soluble adhesion molecules and circulating bacterial endotoxin, and levels of soluble human heat-shock protein 60 and antibodies to mycobacterial heat- shock protein 65 were elevated in subjects with chronic infections and predictive of an increased risk of atherosclerosis.
Journal ArticleDOI
You Are What You Eat-The Relationship between Diet, Microbiota, and Metabolic Disorders-A Review.
TL;DR: How macronutrients (proteins, carbohydrates, fat) and different dietary patterns interact with the composition and activity of GM are described, and how gut bacterial dysbiosis has an influence on metabolic disorders, such as obesity, type 2 diabetes, and hyperlipidemia are described.
Journal ArticleDOI
Regulation of Intestinal Barrier Function by Microbial Metabolites.
TL;DR: A review of recent advances on Gut microbial metabolites in the regulation of intestinal barrier function is presented in this paper, which mainly points to a small group of shared pathways that control gut barrier functions.
Journal ArticleDOI
Role of Oxidative Stress in the Pathogenesis of Non-Alcoholic Fatty Liver Disease: Implications for Prevention and Therapy
TL;DR: In this paper, a review highlights the link between disturbed lipid metabolism and oxidative stress in the context of NAFLD and discusses potential therapies based on antioxidant effects and their likely molecular targets.
Journal ArticleDOI
Associations among Dietary Omega-3 Polyunsaturated Fatty Acids, the Gut Microbiota, and Intestinal Immunity.
Yawei Fu,Yadong Wang,Yadong Wang,Hu Gao,Donghua Li,RuiRui Jiang,Lingrui Ge,Chao Tong,Kang Xu,Kang Xu +9 more
TL;DR: In this paper, the effects of omega-3 PUFAs on intestinal immunity and inflammation were described, and several pathways by which the microbiota modulates the gut immune system through Omega-3PUFAs were identified.
References
More filters
Journal ArticleDOI
An obesity-associated gut microbiome with increased capacity for energy harvest
Peter J. Turnbaugh,Ruth E. Ley,Michael A. Mahowald,Vincent Magrini,Elaine R. Mardis,Jeffrey I. Gordon +5 more
TL;DR: It is demonstrated through metagenomic and biochemical analyses that changes in the relative abundance of the Bacteroidetes and Firmicutes affect the metabolic potential of the mouse gut microbiota and indicates that the obese microbiome has an increased capacity to harvest energy from the diet.
Journal ArticleDOI
Metabolic endotoxemia initiates obesity and insulin resistance
Patrice D. Cani,Jacques Amar,Miguel A. Iglesias,Marjorie Poggi,Claude Knauf,Delphine Bastelica,Audrey M. Neyrinck,Francesca Fava,Kieran Tuohy,Chantal Chabo,Aurélie Waget,Evelyne Delmée,Béatrice Cousin,Thierry Sulpice,Bernard Chamontin,Jean Ferrières,Jean-François Tanti,Glenn R. Gibson,Louis Casteilla,Nathalie M. Delzenne,Marie-Christine Alessi,Rémy Burcelin +21 more
TL;DR: It is concluded that the LPS/CD14 system sets the tone of insulin sensitivity and the onset of diabetes and obesity and lowering plasma LPS concentration could be a potent strategy for the control of metabolic diseases.
Journal ArticleDOI
Richness of human gut microbiome correlates with metabolic markers
Trine Nielsen,Junjie Qin,Edi Prifti,Falk Hildebrand,Gwen Falony,Mathieu Almeida,Manimozhiyan Arumugam,Jean-Michel Batto,Sean Kennedy,Pierre Leonard,Junhua Li,Kristoffer Sølvsten Burgdorf,Niels Grarup,Torben Jørgensen,Torben Jørgensen,Torben Jørgensen,Ivan Brandslund,Henrik Nielsen,Agnieszka S. Juncker,Marcelo Bertalan,Florence Levenez,Nicolas Pons,Simon Rasmussen,Shinichi Sunagawa,Julien Tap,Sebastian Tims,Erwin G. Zoetendal,Søren Brunak,Karine Clément,Karine Clément,Joël Doré,Michiel Kleerebezem,Karsten Kristiansen,Pierre Renault,Thomas Sicheritz-Pontén,Willem M. de Vos,Willem M. de Vos,Jean-Daniel Zucker,Jean-Daniel Zucker,Jean-Daniel Zucker,Jeroen Raes,Torben Hansen,Torben Hansen,Peer Bork,Jun Wang,S. Dusko Ehrlich,Oluf Pedersen +46 more
TL;DR: The authors' classifications based on variation in the gut microbiome identify subsets of individuals in the general white adult population who may be at increased risk of progressing to adiposity-associated co-morbidities.
Journal ArticleDOI
From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites
TL;DR: Data is reviewed supporting the diverse functional roles carried out by a major class of bacterial metabolites, the short-chain fatty acids (SCFAs), which affect various physiological processes and may contribute to health and disease.
Journal ArticleDOI
Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis
Robert A. Koeth,Zeneng Wang,Bruce S. Levison,Jennifer A. Buffa,Elin Org,Brendan Sheehy,Earl B. Britt,Xiaoming Fu,Yuping Wu,Lin Li,Jonathan D. Smith,Joseph A. DiDonato,Jun Chen,Hongzhe Li,Gary D. Wu,James D. Lewis,Manya Warrier,J. Mark Brown,Ronald M. Krauss,W.H. Wilson Tang,Frederic D. Bushman,Aldons J. Lusis,Stanley L. Hazen +22 more
TL;DR: It is demonstrated that metabolism by intestinal microbiota of dietary l-carnitine, a trimethylamine abundant in red meat, also produces TMAO and accelerates atherosclerosis in mice, and intestinal microbiota may contribute to the well-established link between high levels of red meat consumption and CVD risk.