Gut Akkermansia muciniphila ameliorates metabolic dysfunction-associated fatty liver disease by regulating the metabolism of L-aspartate via gut-liver axis.
Yong Rao,Zhi-qi Kuang,Chan Li,Shi-Yao Guo,Yao-Hao Xu,Dan-Dan Zhao,Yu-Tao Hu,Bing-Bing Song,Zhi Jiang,Zhen-Huang Ge,Xi-Yuan Liu,Cheng-Dao Li,Shuo-Bin Chen,Ji-Ming Ye,Zhi-Shu Huang,Yongjun Lu +15 more
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TLDR
Akkermansia muciniphila has been increasingly recognized for its therapeutic potential in treating metabolic disorders, including obesity, diabetes, and metabolicdysfunction-association as discussed by the authors.Abstract:
The gut bacterium Akkermansia muciniphila has been increasingly recognized for its therapeutic potential in treating metabolic disorders, including obesity, diabetes, and metabolicdysfunction-assoc...read more
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The Role of Gut–Liver Axis in Gut Microbiome Dysbiosis Associated NAFLD and NAFLD-HCC
Qian Song,Xiangyu Zhang +1 more
TL;DR: The up-to-date information of gut microbiome dysbiosis and metabolomic changes along the stages of steatosis, NASH, fibrosis, and NAFLD-HCC is summarized.
Journal ArticleDOI
Gut microbiome-mediated mechanisms for reducing cholesterol levels: implications for ameliorating cardiovascular disease.
TL;DR: In this paper , the authors discuss the potential mechanisms by which the gut microbiota reduces cholesterol levels and sketch the application of probiotics from the genera Lactobacillus and Bifidobacterium in reducing cholesterol levels in clinical studies.
Journal ArticleDOI
Revisiting the role of Akkermansia muciniphila as a therapeutic bacterium
TL;DR: The molecular, mechanistic effects of A. muciniphila in host health are evaluated and some of the missing links to be connected are suggested before the organism should be considered as a next-generation biotherapeutic agent.
Journal ArticleDOI
Maternal consumption of a fermented diet protects offspring against intestinal inflammation by regulating the gut microbiota
TL;DR: These findings provide the first data revealing that an MFD drives neonate gut microbiota development and ameliorates the colonic inflammation by regulating the gut microbiota.
Journal ArticleDOI
Native and Engineered Probiotics: Promising Agents against Related Systemic and Intestinal Diseases
TL;DR: The aims of this review are to summarize the roles of potential native and engineered probiotics in oncology, inflammatory bowel disease, and obesity, discussing the therapeutic applications of these probiotics.
References
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Journal ArticleDOI
Acute appendicitis is characterised by local invasion with Fusobacterium nucleatum/necrophorum
Alexander Swidsinski,Yvonne Dörffel,Vera Loening-Baucke,Franz Theissig,Jens C. Rückert,Mahmoud Ismail,Walter A Rau,Dagmar Gaschler,Michael Weizenegger,Sigmar Kühn,Johannes Schilling,Wolf V. Dörffel +11 more
TL;DR: Local infection with Fusobacterium nucleatum/necrophorum is responsible for the majority of cases of acute appendicitis, and is inversely related to the severity of the disease.
Journal ArticleDOI
Akkermansia muciniphila is a promising probiotic.
TL;DR: The bacteriological characteristics and safety of A. muciniphila, an intestinal symbiont colonizing in the mucosal layer, as well as its causal relationship with metabolic disorders, immune diseases and cancer therapy are reviewed.
Journal ArticleDOI
Dietary cholesterol drives fatty liver-associated liver cancer by modulating gut microbiota and metabolites
Xiang Zhang,Olabisi Oluwabukola Coker,Eagle Sh Chu,Kaili Fu,Harry Cheuk Hay Lau,Yi-Xiang J. Wang,Anthony W.H. Chan,Hong Wei,Xiaoyong Yang,Joseph J.Y. Sung,Jun Yu +10 more
TL;DR: Dietary cholesterol drives NAFLD–HCC formation by inducing alteration of gut microbiota and metabolites in mice and atorvastatin restored cholesterol-induced gut microbiota dysbiosis and completely preventedNAFLD-HCC development.
Journal ArticleDOI
Differences in Gut Microbiota in Patients With vs Without Inflammatory Bowel Diseases: A Systematic Review.
Rapat Pittayanon,Rapat Pittayanon,Rapat Pittayanon,Jennifer T. Lau,Grigorios I. Leontiadis,Frances Tse,Yuhong Yuan,Michael G. Surette,Paul Moayyedi +8 more
TL;DR: Evidence for differences in abundances of some bacteria in patients with IBD vs controls is found, but one cannot make conclusions due to inconsistent results and methods among studies.
Journal ArticleDOI
Administration of Akkermansia muciniphila Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice.
Xiaoyuan Bian,Wenrui Wu,Liya Yang,Longxian Lv,Qing Wang,Yating Li,Jianzhong Ye,Daiqiong Fang,Jingjing Wu,Xianwan Jiang,Ding Shi,Lanjuan Li +11 more
TL;DR: It is found that A. muciniphila treatment could ameliorate mucosal inflammation either via microbe-host interactions, which protect the gut barrier function and reduce the levels of inflammatory cytokines, or by improving the microbial community.
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