Gut microbiota fermentation of prebiotics increases satietogenic and incretin gut peptide production with consequences for appetite sensation and glucose response after a meal
Patrice D. Cani,Elodie Lecourt,Evelyne M. Dewulf,Florence M. Sohet,Barbara D. Pachikian,Damien Naslain,Fabienne De Backer,Audrey M. Neyrinck,Nathalie M. Delzenne +8 more
TLDR
Prebiotic supplementation was associated with an increase in plasma gut peptide concentrations (glucagon-like peptide 1 and peptide YY), which may contribute in part to changes in appetite sensation and glucose excursion responses after a meal in healthy subjects.About:
This article is published in The American Journal of Clinical Nutrition.The article was published on 2009-11-01 and is currently open access. It has received 658 citations till now. The article focuses on the topics: Peptide YY & Glucose homeostasis.read more
Citations
More filters
Journal ArticleDOI
Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics
Glenn R. Gibson,Robert W. Hutkins,Mary Ellen Sanders,Susan L. Prescott,Raylene A. Reimer,Seppo Salminen,Karen P. Scott,Catherine Stanton,Kelly S. Swanson,Patrice D. Cani,Kristin Verbeke,Gregor Reid +11 more
TL;DR: The goal of this Consensus Statement is to engender appropriate use of the term 'prebiotic' by relevant stakeholders so that consistency and clarity can be achieved in research reports, product marketing and regulatory oversight of the category.
Journal ArticleDOI
Prebiotic effects: metabolic and health benefits.
Marcel Roberfroid,Glenn R. Gibson,Lesley Hoyles,Anne L. McCartney,Robert A. Rastall,Ian Rowland,Danielle Wolvers,Bernhard Watzl,Hania Szajewska,Bernd Stahl,Francisco Guarner,Frédérique Respondek,Kevin Whelan,Véronique Coxam,Marie-Jeanne Davicco,Laurent Léotoing,Yohann Wittrant,Nathalie M. Delzenne,Patrice D. Cani,Audrey M. Neyrinck,Agnes Meheust +20 more
TL;DR: The present document has been written by a group of both academic and industry experts and aims to validate and expand the original idea of the prebiotic concept, defined as the selective stimulation of growth and/or activity of one or a limited number of microbial genus(era)/species in the gut microbiota that confer(s) health benefits to the host.
Journal ArticleDOI
Fiber and prebiotics: mechanisms and health benefits.
TL;DR: Inulin, fructo-oligosaccharides, and other oligosACcharides are included as dietary fiber in food labels in the US as discussed by the authors, and they are the best known prebiotics, a selectively fermented ingredient that allows specific changes, both in the composition and/or activity in the gastrointestinal microflora that confers benefits upon host wellbring and health.
Journal ArticleDOI
Short-chain Fatty Acids in Control of Body Weight and Insulin Sensitivity
TL;DR: This Review discusses the effects of three SCFA on energy homeostasis and metabolism, as well as how these SCFA can beneficially modulate adipose tissue, skeletal muscle and liver tissue function and the increasing evidence for a potential role of SCFA as metabolic targets to prevent and counteract obesity.
Journal ArticleDOI
Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes
Liping Zhao,Liping Zhao,Feng Zhang,Xiaoying Ding,Guojun Wu,Yan Y. Lam,Xuejiao Wang,Huaqing Fu,Xinhe Xue,Chunhua Lu,Jilin Ma,Lihua Yu,Chengmei Xu,Zhongying Ren,Ying Xu,Songmei Xu,Hongli Shen,Xiuli Zhu,Yu Shi,Qingyun Shen,Weiping Dong,Rui Liu,Yunxia Ling,Yue Zeng,Xing-peng Wang,Qianpeng Zhang,Jing Wang,Linghua Wang,Yanqiu Wu,Benhua Zeng,Hong Wei,Menghui Zhang,Yongde Peng,Chenhong Zhang +33 more
TL;DR: It is found that adopting a high-fiber diet promoted the growth of SCFA-producing organisms in diabetic humans and had better improvement in hemoglobin A1c levels, partly via increased glucagon-like peptide-1 production.
References
More filters
Journal ArticleDOI
Metabolic endotoxemia initiates obesity and insulin resistance
Patrice D. Cani,Jacques Amar,Miguel A. Iglesias,Marjorie Poggi,Claude Knauf,Delphine Bastelica,Audrey M. Neyrinck,Francesca Fava,Kieran Tuohy,Chantal Chabo,Aurélie Waget,Evelyne Delmée,Béatrice Cousin,Thierry Sulpice,Bernard Chamontin,Jean Ferrières,Jean-François Tanti,Glenn R. Gibson,Louis Casteilla,Nathalie M. Delzenne,Marie-Christine Alessi,Rémy Burcelin +21 more
TL;DR: It is concluded that the LPS/CD14 system sets the tone of insulin sensitivity and the onset of diabetes and obesity and lowering plasma LPS concentration could be a potent strategy for the control of metabolic diseases.
Journal ArticleDOI
The biology of incretin hormones.
TL;DR: Current concepts of incretin action are summarized and the potential therapeutic utility of GLP-1 receptor agonists and dipeptidyl peptidase-4 (DPP-4) inhibitors for the treatment of type 2 diabetes is highlighted.
Journal ArticleDOI
Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia.
Patrice D. Cani,Audrey M. Neyrinck,Francesca Fava,Claude Knauf,Rémy Burcelin,Kieran Tuohy,Glenn R. Gibson,Nathalie M. Delzenne,Nathalie M. Delzenne +8 more
TL;DR: The findings suggest that the gut microbiota contribute towards the pathophysiological regulation of endotoxaemia and set the tone of inflammation for occurrence of diabetes and/or obesity.
Journal ArticleDOI
On the presence of inulin and oligofructose as natural ingredients in the western diet.
TL;DR: Methods to determine inulin and oligofructose in natural foodstuffs are optimized and used to determine the loss of inulin during storage and during preparation of the food, which allow quantification of the amount of in insulin and olig ofructose in the average daily western diet.
Journal ArticleDOI
The role of the gut microbiota in energy metabolism and metabolic disease.
TL;DR: Data obtained in experimental models and human subjects are in favour of the fact that changing the gut microbiota (with prebiotics and/or probiotics) may participate in the control of the development of metabolic diseases associated with obesity.
Related Papers (5)
Microbial ecology: Human gut microbes associated with obesity
Metabolic endotoxemia initiates obesity and insulin resistance
Patrice D. Cani,Jacques Amar,Miguel A. Iglesias,Marjorie Poggi,Claude Knauf,Delphine Bastelica,Audrey M. Neyrinck,Francesca Fava,Kieran Tuohy,Chantal Chabo,Aurélie Waget,Evelyne Delmée,Béatrice Cousin,Thierry Sulpice,Bernard Chamontin,Jean Ferrières,Jean-François Tanti,Glenn R. Gibson,Louis Casteilla,Nathalie M. Delzenne,Marie-Christine Alessi,Rémy Burcelin +21 more