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Haematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair
Anne Wilson,G. Osee,R. van der Wath,William Blanco-Bose,Elisa Laurenti,Cyrille F. Dunant,Pietro Liò,H. R. MacDonald,Andreas Trumpp +8 more
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In this article, the authors present a Web of Science Record created on 2010-11-30, modified on 2016-08-09 and used for the publication of this paper.Abstract:
Reference EPFL-CONF-161003View record in Web of Science Record created on 2010-11-30, modified on 2016-08-09read more
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The bone marrow niche for haematopoietic stem cells
TL;DR: The haematopoietic stem cell niche remains incompletely defined and beset by competing models, and outstanding questions concern the cellular complexity of the niche, the role of the endosteum and functional heterogeneity among perivascular microenvironments.
Journal ArticleDOI
IFNα activates dormant haematopoietic stem cells in vivo
Marieke A.G. Essers,Sandra Offner,William Blanco-Bose,Zoe Waibler,Ulrich Kalinke,Michel A. Duchosal,Andreas Trumpp +6 more
TL;DR: It is shown that in response to treatment of mice with interferon-α (IFNα), HSCs efficiently exit G0 and enter an active cell cycle, raising the possibility for new applications of type I interferons to target cancer stem cells.
Journal ArticleDOI
Mammalian heart renewal by pre-existing cardiomyocytes
Samuel E. Senyo,Matthew L. Steinhauser,Christie L Pizzimenti,Vicky K. Yang,Lei Cai,Mei Wang,Ting-Di Wu,Ting-Di Wu,Jean-Luc Guerquin-Kern,Jean-Luc Guerquin-Kern,Claude Lechene,Richard T. Lee,Richard T. Lee +12 more
TL;DR: It is found that cell cycle activity during normal ageing and after injury led to polyploidy and multinucleation, but also to new diploid, mononucleate cardiomyocytes.
Journal ArticleDOI
Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches
Lei Ding,Sean J. Morrison +1 more
TL;DR: Assessment of the physiological sources of the chemokine CXCL12 for HSC and restricted progenitor maintenance shows that Cxcl12 was primarily expressed by perivascular stromal cells and, at lower levels, by endothelial cells, osteoblasts and some haematopoietic cells.
Journal ArticleDOI
A reserve stem cell population in small intestine renders Lgr5 -positive cells dispensable
Hua Tian,Brian Biehs,Søren Warming,Kevin G. Leong,Linda Rangell,Ophir D. Klein,Frederic J. de Sauvage +6 more
TL;DR: It is found that complete loss of the Lgr5-expressing cells did not perturb homeostasis of the epithelium, indicating that other cell types can compensate for the elimination of this population, and that in the absence of these cells, Bmi1- expressing cells can serve as an alternative stem cell pool.
References
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Journal ArticleDOI
Identification of stem cells in small intestine and colon by marker gene Lgr5
Nick Barker,Johan H. van Es,Jeroen Kuipers,Pekka Kujala,Maaike van den Born,Miranda Cozijnsen,Andrea Haegebarth,Jeroen Korving,Harry Begthel,Peter J. Peters,Hans Clevers +10 more
TL;DR: The expression pattern of Lgr5 suggests that it marks stem cells in multiple adult tissues and cancers, suggesting that it represents the stem cell of the small intestine and colon.
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SLAM Family Receptors Distinguish Hematopoietic Stem and Progenitor Cells and Reveal Endothelial Niches for Stem Cells
Mark J. Kiel,Ömer H. Yilmaz,Toshihide Iwashita,Osman H. Yilmaz,Cox Terhorst,Sean J. Morrison +5 more
TL;DR: This work compared the gene expression profiles of highly purified HSCs and non-self-renewing multipotent hematopoietic progenitors and found that both groups occupied multiple niches, including sinusoidal endothelium in diverse tissues.
Journal ArticleDOI
Identification of the haematopoietic stem cell niche and control of the niche size
Jiwang Zhang,Chao Niu,Ling Ye,Haiyang Huang,Xi C. He,Wei Gang Tong,Jason Ross,Jeffrey S. Haug,Teri Johnson,Jian Q. Feng,Stephen E. Harris,Leanne M. Wiedemann,Leanne M. Wiedemann,Yuji Mishina,Linheng Li,Linheng Li +15 more
TL;DR: It is concluded that SNO cells lining the bone surface function as a key component of the niche to support HSCs, and that BMP signalling through BMPRIA controls the number of H SCs by regulating niche size.
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Label-retaining cells reside in the bulge area of pilosebaceous unit: Implications for follicular stem cells, hair cycle, and skin carcinogenesis
TL;DR: It is suggested that follicular stem cells reside in the bulge region, instead of the lower bulb, which provides insights into hair cycle control and the possible involvement of hair follicle stem cells in skin carcinogenesis.
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Long-Term Lymphohematopoietic Reconstitution by a Single CD34-Low/Negative Hematopoietic Stem Cell
TL;DR: A monoclonal antibody raised to the mouse homolog of CD34 (mCD34) was used to purify mouse HSCs to near homogeneity to enable analysis of the self-renewal and multilineage differentiation of individual HSCS.