Hantavirus Inhibits TRAIL-Mediated Killing of Infected Cells by Downregulating Death Receptor 5
Carles Solà-Riera,Shawon Gupta,Shawon Gupta,Kimia T. Maleki,Patricia González-Rodríguez,Dalel Saidi,Christine L. Zimmer,Sindhu Vangeti,Laura Rivino,Yee Sin Leo,David C. Lye,Paul A. MacAry,Clas Ahlm,Anna Smed-Sörensen,Bertrand Joseph,Niklas K. Björkström,Hans-Gustaf Ljunggren,Jonas Klingström +17 more
TLDR
The findings show that HTNV counteracts intrinsic and extrinsic apoptosis induction pathways, providing a defense mechanism utilized by hantaviruses to inhibit cytotoxic cell-mediated eradication of infected cells.About:
This article is published in Cell Reports.The article was published on 2019-08-20 and is currently open access. It has received 19 citations till now. The article focuses on the topics: Intrinsic apoptosis & Cytotoxic T cell.read more
Citations
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Journal ArticleDOI
TRAIL in oncology: From recombinant TRAIL to nano- and self-targeted TRAIL-based therapies.
Hassan Dianat-Moghadam,Maryam Heidarifard,Amir Mahari,Mehdi Shahgolzari,Mohsen Keshavarz,Mohammad Nouri,Zohreh Amoozgar +6 more
TL;DR: The complex biology of TRAIL signaling, including TRAILs cross-talk with other signaling pathways and immune cells, is summarized and strategies with the potential to overcome the challenges that cannot be addressed via nanotechnology alone are specified.
Journal ArticleDOI
Genome structural variation in human evolution
TL;DR: Structural variation (SV) is a large difference (typically >100 bp) in the genomic structure of two genomes and includes both copy number variation and variation that does not change copy number of a genomic region, such as an inversion as discussed by the authors .
Journal ArticleDOI
Genome structural variation in human evolution
TL;DR: Structural variation (SV) is a large difference (typically >100 bp) in the genomic structure of two genomes and includes both copy number variation and variation that does not change copy number of a genomic region, such as an inversion as discussed by the authors.
Journal ArticleDOI
Hantavirus inhibits apoptosis by preventing mitochondrial membrane potential loss through up-regulation of the pro-survival factor BCL-2.
TL;DR: Overall, this work provides a tentative mechanism by which hantaviruses protect infected cells from intrinsic apoptosis at the mitochondrial level by inducing an increased expression of the pro-survival factor BCL-2, thereby preventing MOMPs and subsequent activation of caspases.
Journal ArticleDOI
IL-33 Alleviated Brain Damage via Anti-apoptosis, Endoplasmic Reticulum Stress, and Inflammation After Epilepsy.
Yuan Gao,Chengliang Luo,Y Yao,J J Huang,Huifang Fu,Chongjian Xia,Guang-Hua Ye,Lin-Sheng Yu,Jun-Ge Han,Yan-Yan Fan,Luyang Tao +10 more
TL;DR: IL-33 attenuates RNS-induced neurobehavioral disorders, bodyweight loss, and spatial learning and memory deficits, at least in part through mechanisms involved in inhibition of apoptosis, ER stress, and neuro-inflammation.
References
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Avi Ashkenazi,Roger Pai,Sharon Fong,Susan Leung,David A. Lawrence,Scot A. Marsters,Christine Blackie,Ling Chang,Amy E. McMurtrey,Andrea Hebert,Laura DeForge,Iphigenia Koumenis,Derf Lewis,Louise A. Harris,Jeanine L. Bussiere,Hartmut Koeppen,Zahra Shahrokh,Ralph H. Schwall +17 more
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Guohua Pan,Karen O'Rourke,Arul M. Chinnaiyan,Reiner L. Gentz,Reinhard Ebner,Jian Ni,Vishva M. Dixit +6 more
TL;DR: The DR4-TRAIL axis defines another receptor-ligand pair involved in regulating cell suicide and tissue homeostasis.
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James P. Sheridan,Scot A. Marsters,Robert M. Pitti,Austin L. Gurney,Maya Skubatch,Daryl T. Baldwin,Lakshmi Ramakrishnan,Christa L. Gray,Kevin P. Baker,William I. Wood,Audrey Goddard,Paul J. Godowski,Avi Ashkenazi +12 more
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