Journal ArticleDOI
Health-related quality of life in elderly, newly diagnosed multiple myeloma patients treated with VMP vs. MP: Results from the VISTA trial
Michel Delforge,Ravinder Dhawan,Don Robinson,Juliette Meunier,Antoine Regnault,Dixie-Lee Esseltine,Andrew Cakana,Helgi van de Velde,Paul G. Richardson,Jesús F. San Miguel +9 more
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TLDR
The phase 3 VISTA study in transplant‐ineligible myeloma patients demonstrated superior efficacy with bortezomib‐melphalan‐prednisone but also increased toxicity.Citations
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Treatment of Multiple Myeloma: ASCO and CCO Joint Clinical Practice Guideline.
Joseph Mikhael,Nofisat Ismaila,Matthew C. Cheung,Caitlin Costello,Madhav V. Dhodapkar,Shaji Kumar,Martha Q. Lacy,Brea Lipe,Richard F. Little,Anna S. Nikonova,James L. Omel,Namrata Peswani,Anca Prica,Noopur Raje,Rahul Seth,David H. Vesole,David H. Vesole,Irwin Walker,Alexander C Whitley,Tanya M. Wildes,Sandy W. Wong,Thomas Martin +21 more
TL;DR: Evidence-based recommendations were developed for patients with multiple myeloma who are transplantation eligible and those who are ineligible and for Patients with relapsed or refractory disease.
Journal ArticleDOI
Community-Based Phase IIIB Trial of Three UPFRONT Bortezomib-Based Myeloma Regimens
Ruben Niesvizky,Ian W. Flinn,Robert M. Rifkin,Nashat Y. Gabrail,Veena Charu,Billy Clowney,James Essell,Yousuf Gaffar,Thomas A. Warr,Rachel Neuwirth,Yanyan Zhu,Jennifer Elliott,Dixie-Lee Esseltine,Liviu Niculescu,James A. Reeves +14 more
TL;DR: Although all bortezomib-containing regimens produced good outcomes, VTD and VMP did not appear to offer an advantage over VD in transplantation-ineligible patients with myeloma treated in US community practice.
Journal ArticleDOI
Effect of general symptom level, specific adverse events, treatment patterns, and patient characteristics on health-related quality of life in patients with multiple myeloma: results of a European, multicenter cohort study
Karin Jordan,Irina Proskorovsky,Philip Lewis,Jack Ishak,K Payne,Noreen Lordan,Charalampia Kyriakou,Cathy D. Williams,Sarah Peters,Faith E. Davies +9 more
TL;DR: Severity, type of disease symptoms, and treatment-related AEs are important HRQoL determinants in patients with MM, allowing for targeted treatment.
Journal ArticleDOI
Review of health-related quality of life data in multiple myeloma patients treated with novel agents
TL;DR: Evaluation of HRQoL in MM patients treated with novel MM therapeutic agents is required in larger cohorts, and ideally in head-to-head comparative studies, and the development of standardised MM-specific best practice guidelines in HRZoL data collection and analysis is recommended.
Journal ArticleDOI
Carfilzomib or bortezomib with melphalan-prednisone for transplant-ineligible patients with newly diagnosed multiple myeloma
Thierry Facon,Jae Hoon Lee,Philippe Moreau,Ruben Niesvizky,Meletios A. Dimopoulos,Roman Hájek,Ludek Pour,Artur Jurczyszyn,Lugui Qiu,Zandra Klippel,Anita Zahlten-Kumeli,Muhtarjan Osman,Bruno Paiva,Jesús F. San-Miguel +13 more
TL;DR: Treatment with KMP in CLARION did not yield a statistically significant difference in PFS vs VMP, and overall survival was similar and not reached in either group.
References
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Journal ArticleDOI
International staging system for multiple myeloma.
Philip R. Greipp,Jesús F. San Miguel,Brian G.M. Durie,John Crowley,Bart Barlogie,Joan Bladé,Mario Boccadoro,J. Anthony Child,Hervé Avet-Loiseau,Robert A. Kyle,Juan J. Lahuerta,Heinz Ludwig,Gareth J. Morgan,R. L. Powles,Kazuyuki Shimizu,Chaim Shustik,Pieter Sonneveld,Patrizia Tosi,Ingemar Turesson,Jan Westin +19 more
TL;DR: The new International Staging System (ISS) is simple, based on easy to use variables (Sbeta2M and serum albumin), and recommended for early adoption and widespread use.
Journal ArticleDOI
Improved survival in multiple myeloma and the impact of novel therapies
Shaji Kumar,S. Vincent Rajkumar,Angela Dispenzieri,Martha Q. Lacy,Suzanne R. Hayman,Francis K. Buadi,Steven R. Zeldenrust,David Dingli,Stephen J. Russell,John A. Lust,Philip R. Greipp,Robert A. Kyle,Morie A. Gertz +12 more
TL;DR: Improved outcome of patients with myeloma in recent years is demonstrated, both in the relapsed setting as well as at diagnosis, both from time of diagnosis and the time of relapse.
Journal ArticleDOI
Review of 1027 Patients With Newly Diagnosed Multiple Myeloma
Robert A. Kyle,Morie A. Gertz,Thomas E. Witzig,John A. Lust,Martha Q. Lacy,Angela Dispenzieri,Rafael Fonseca,S. Vincent Rajkumar,Janice R. Offord,Dirk R. Larson,Matthew E. Plevak,Terry M. Therneau,Philip R. Greipp +12 more
TL;DR: Multivariate analysis revealed that age, plasma cell labeling index, low platelet count, serum albumin value, and the log of the creatinine value were the most important prognostic factors for newly diagnosed multiple myeloma.
Journal ArticleDOI
Bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma.
Jesús F. San Miguel,Rudolf Schlag,Nuriet K. Khuageva,Meletios A. Dimopoulos,Ofer Shpilberg,Martin Kropff,Ivan Spicka,Maria Teresa Petrucci,Antonio Palumbo,Olga Samoilova,Anna Dmoszynska,Kudrat Abdulkadyrov,Rik Schots,Bin Jiang,Maria-Victoria Mateos,Kenneth C. Anderson,Dixie Lee Esseltine,Kevin Liu,Andrew Cakana,Helgi van de Velde,Paul G. Richardson +20 more
TL;DR: Bortezomib plus melphalan-prednisone alone in patients with newly diagnosed myeloma who were ineligible for high-dose therapy was superior to melphAlan-predisonsone alone.
Journal ArticleDOI
Criteria for evaluating disease response and progression in patients with multiple myeloma treated by high-dose therapy and haemopoietic stem cell transplantation. Myeloma Subcommittee of the EBMT. European Group for Blood and Marrow Transplant.
Joan Bladé,Diana Samson,Donna E. Reece,Jane F. Apperley,Bo Björkstrand,Gösta Gahrton,Morie A. Gertz,Sergio Giralt,SUNDARr Jagannath,David H. Vesole +9 more
TL;DR: New criteria for response and progression have been developed as a result of discussions between representatives of the Myeloma Subcommittee of the Chronic Leukaemia Working Party of the European Group for Blood and Marrow Transplantation (EBMT) and representatives ofThe Myelomas Working Committee of the Autologousblood and marrow transplant Registry (ABMTR) and the International Bone Marrowtransplant Registry (IBMTR).
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Continuous Lenalidomide Treatment for Newly Diagnosed Multiple Myeloma
Antonio Palumbo,Roman Hájek,Michel Delforge,Martin Kropff,Maria Teresa Petrucci,John Catalano,Heinz Gisslinger,Wieslaw Wiktor-Jedrzejczak,Mamia Zodelava,Katya C Weisel,Nicola Cascavilla,Genadi Iosava,Michele Cavo,Janusz Kloczko,Joan Bladé,Meral Beksac,Ivan Spicka,Torben Plesner,Joergen Radke,Christian Langer,Dina Ben Yehuda,Alessandro Corso,Lindsay Herbein,Zhinuan Yu,Jay Mei,Christian Jacques,Meletios A. Dimopoulos +26 more