Open AccessJournal Article
Herbs and herbal constituents active against snake bite.
Antony Gomes,Rinku Das,Sumana Sarkhel,Roshnara Mishra,Sanghamitra Mukherjee,Shamik Bhattacharya,Aparna Gomes +6 more
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TLDR
The present review has been focussed on the varied folk and traditional herbs and their antisnake venom compounds, which might be a stepping stone in establishing the future therapy against snake bite treatment and management.Abstract:
Snake bite, a major socio-medical problem of south east asian countries is still depending on the usage of antisera as the one and only source of treatment, which has its own limitations. In India, mostly in rural areas, health centres are inadequate and the snake bite victims mostly depend on traditional healers and herbal antidotes, as an alternative treatment. The present review has been focussed on the varied folk and traditional herbs and their antisnake venom compounds, which might be a stepping stone in establishing the future therapy against snake bite treatment and management.read more
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In vitro antioxidant and free radical scavenging activity of different parts of Tabebuia pallida growing in Bangladesh
TL;DR: Methanolic extract of T. pallida leaf is a potential source of natural antioxidants and serves as an effective free radical scavenger and/or inhibitor and might be a good plant-based pharmaceutical product for several diseases caused by free radicals.
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Neurotoxicity in Snakebite—The Limits of Our Knowledge
TL;DR: A uniform system of classification of the pattern of neuromuscular weakness and models for predicting type of toxicity and development of respiratory weakness are still lacking, and would greatly aid clinical decision making and future research.
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The genus Achyranthes: A review on traditional uses, phytochemistry, and pharmacological activities.
Xirui He,Xiaoxiao Wang,Jiacheng Fang,Yu Chang,Ning Ning,Hao Guo,Linhong Huang,Xiaoqiang Huang +7 more
TL;DR: This review aims to provide systematically reorganized information on distributions, botanical characteristics, ethnopharmacology, chemical constituents, qualitative and quantitative analysis, pharmacological activities, and toxicity of Achyranthes species to support their therapeutic potential.
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Medicinal Plants for the Treatment of Local Tissue Damage Induced by Snake Venoms: An Overview from Traditional Use to Pharmacological Evidence.
Juliana Félix-Silva,Arnóbio Antônio da Silva-Júnior,Silvana Maria Zucolotto,Matheus F. Fernandes-Pedrosa +3 more
TL;DR: The present review provides an updated scenario and insights into future research aiming at validation of medicinal plants as antiophidic agents and strengthens the potentiality of ethnopharmacology as a tool for design of potent inhibitors and/or development of herbal medicines against venom toxins, especially local tissue damage.
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In vitro callus induction and plantlet regeneration of Achyranthes aspera L., a high value medicinal plant.
TL;DR: Different explants were good source of callus induction, morphology analysis as well as indirect plantlets regeneration and in vitro plantlets propagation from medicinally important plant Achyranthes aspera L.
References
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Neutralizing properties of Musa paradisiaca L. (Musaceae) juice on phospholipase A2, myotoxic, hemorrhagic and lethal activities of crotalidae venoms.
Márcia H. Borges,D.L.F. Alves,D.S. Raslan,Dorila Piló-Veloso,Veridiana M. Rodrigues,Maria Inês Homsi-Brandeburgo,M.E. de Lima +6 more
TL;DR: According to the results, using mice as experimental model, MsE does not show protection against the toxic effects of snake venoms in vivo, but if was very effective when the experiments were done in vitro.
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Neo-clerodane diterpenoid, a new metalloprotease snake venom inhibitor from Baccharis trimera (Asteraceae): anti-proteolytic and anti-hemorrhagic properties.
Ana Helena Januário,Simone L. Santos,Silvana Marcussi,Maurício V. Mazzi,Rosemeire Cristina Linhari Rodrigues Pietro,Rosemeire Cristina Linhari Rodrigues Pietro,Daisy N. Sato,Javier Ellena,Suely Vilela Sampaio,Suzelei C. França,Andreimar M. Soares +10 more
TL;DR: The anti-proteolytic and anti-hemorrhagic properties against snake venoms of a Bt-CD inhibitor from B. trimera are reported and the potential use of these inhibitors to complement anti-venom as an alternative treatment of snakebite envenomations needs to be evaluated in future studies.
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Identification of Glycyrrhizin as a Thrombin Inhibitor
TL;DR: Evidence is provided that GL is a selective inhibitor of thrombin that is able to exert its anti-thrombin action by interacting with the enzyme's anion binding exosite 1 and a pharmacophoric search identified GL as a sialyl Lewis X (SLe[X]) mimetic compound able to inhibit selectin binding to SLe(X).
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Antiophidian properties of the aqueous extract of Mikania glomerata.
Victor A. Maiorano,Silvana Marcussi,Maristela A.F. Daher,Clayton Z. Oliveira,Clayton Z. Oliveira,Lucélio B. Couto,Odair A. Gomes,Suzelei C. França,Andreimar M. Soares,Paulo Pereira +9 more
TL;DR: Since the extract of Mikania glomerata significantly inhibited the studied snake venoms, it may be used as an alternative treatment to serumtherapy and, in addition, as a rich source of potential inhibitors of PLA(2)s, metalloproteases and serineproteases, enzymes involved in several physiopathological human and animal diseases.
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Inhibition of Naja naja venom hyaluronidase by plant-derived bioactive components and polysaccharides.
TL;DR: The inhibitors of hyaluronidase could be used as potent first aid agents in snakebite therapy because they not only reduce the local tissue damage but also retard the easy diffusion of systemic toxins and hence increase survival time.