Journal ArticleDOI
High-efficiency intracellular magnetic labeling with novel superparamagnetic-Tat peptide conjugates.
Reads0
Chats0
TLDR
A biocompatible, dextran coated superparamagnetic iron oxide particle was derivatized with a peptide sequence from the HIV-tat protein to improve intracellular magnetic labeling of different target cells, and internalized into lymphocytes over 100-fold more efficiently than nonmodified particles.About:
This article is published in Bioconjugate Chemistry.The article was published on 1999-02-26. It has received 959 citations till now.read more
Citations
More filters
Journal ArticleDOI
Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications
Ajay Kumar Gupta,Mona Gupta +1 more
TL;DR: This review discusses the synthetic chemistry, fluid stabilization and surface modification of superparamagnetic iron oxide nanoparticles, as well as their use for above biomedical applications.
Journal ArticleDOI
Magnetic Iron Oxide Nanoparticles: Synthesis, Stabilization, Vectorization, Physicochemical Characterizations, and Biological Applications
Sophie Laurent,Delphine Forge,Marc Port,Alain Roch,Caroline Robic,Luce Vander Elst,Robert N. Muller +6 more
TL;DR: Practical Interests of Magnetic NuclearRelaxation for the Characterization of Superparamagnetic Colloid, and Use of Nanoparticles as Contrast Agents forMRI20825.
Book ChapterDOI
Applications of magnetic nanoparticles in biomedicine
TL;DR: The physical principles underlying some current biomedical applications of magnetic nanoparticles are reviewed and the relevant physics of magnetic materials and their responses to applied magnetic fields are surveyed.
Journal ArticleDOI
Magnetic Nanoparticles in MR Imaging and Drug Delivery
TL;DR: A background on applications of MNPs as MR imaging contrast agents and as carriers for drug delivery and an overview of the recent developments in this area of research are provided.
Journal ArticleDOI
Molecular imaging in living subjects: seeing fundamental biological processes in a new light
TL;DR: This article cites 228 articles, 79 of which can be accessed free at: service Email alerting click here top right corner of the article or Receive free email alerts when new articles cite this article sign up in the box at the Collections Topic.
References
More filters
Journal ArticleDOI
A truncated HIV-1 Tat protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus
TL;DR: The main determinants required for Tat translocation within this sequence are delineated by synthesizing several peptides covering the Tat domain from residues 37 to 60 and the domain extending from amino acid 37 to 47, which corresponds to the α-helix structure, is not required for cellular uptake and for nuclear translocation.
Journal ArticleDOI
Cell Internalization of the Third Helix of the Antennapedia Homeodomain Is Receptor-independent
Daniele Derossi,Sophie Calvet,Alain Trembleau,Alié Brunissen,Gérard Chassaing,Alain Prochiantz +5 more
TL;DR: The present demonstration, that a reverse helix and a helix composed of D-enantiomers still translocate across biological membranes at 4 and 37°C strongly suggests that the third helix of the homeodomain is internalized by a receptor-independent mechanism.
Journal ArticleDOI
Magnetic separation techniques in diagnostic microbiology.
TL;DR: IMS has been demonstrated to be a useful method in diagnostic microbiology and described as a method for enhancing the specificity and sensitivity of other detection systems, such as PCR, and providing considerable savings in time compared with traditional diagnostic systems.
Journal ArticleDOI
Magnetically labeled cells can be detected by MR imaging
TL;DR: It is concluded that a variety of cells can be efficiently labeled with MION by simple incubation and may be used for MR imaging of in vivo cell tracking.
Journal ArticleDOI
Intercellular delivery of functional p53 by the herpesvirus protein VP22.
TL;DR: It is shown that chimeric polypeptides, consisting of VP22 linked to the entire p53 protein, retain their ability to spread between cells and accumulate in recipient cell nuclei, indicating that VP22 delivery may have applications in gene therapy.
Related Papers (5)
Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications
Ajay Kumar Gupta,Mona Gupta +1 more