Journal ArticleDOI
Histone lysine methylation: a signature for chromatin function
TLDR
The functional properties of histone lysine methylation and the enzymes that catalyze this covalent modification are reviewed.About:
This article is published in Trends in Genetics.The article was published on 2003-11-01. It has received 682 citations till now. The article focuses on the topics: Histone lysine methylation & Histone methyltransferase.read more
Citations
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A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin
Gunnar Schotta,Monika Lachner,Kavitha Sarma,Anja Ebert,Roopsha Sengupta,Gunter Reuter,Danny Reinberg,Thomas Jenuwein +7 more
TL;DR: Together, the data indicate a function for H4-K20 trimethylation in gene silencing and further suggest H3-K9 and H4,K20 trimmedethylation as important components of a repressive pathway that can index pericentric heterochromatin.
Journal ArticleDOI
Regulation of HP1–chromatin binding by histone H3 methylation and phosphorylation
Wolfgang Fischle,Boo Shan Tseng,Holger L. Dormann,Beatrix Ueberheide,Benjamin A. Garcia,Jeffrey Shabanowitz,Donald F. Hunt,Hironori Funabiki,C. David Allis +8 more
TL;DR: It is shown that HP1α, -β, and -γ are released from chromatin during the M phase of the cell cycle, even though tri-methylation levels of histone H3 lysine 9 remain unchanged, and a regulatory mechanism of protein–protein interactions is established through a combinatorial readout of two adjacent post-translational modifications: a stable methylation and a dynamic phosphorylation mark.
Journal ArticleDOI
The functions of E(Z)/EZH2-mediated methylation of lysine 27 in histone H3
TL;DR: In addition to being involved in Hox gene silencing, the ESC-E(Z) complex and its associated histone methyltransferase activity are important in other biological processes including X-inactivation, germline development, stem cell pluripotency and cancer metastasis.
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Vernalization requires epigenetic silencing of FLC by histone methylation
Ruth Bastow,Joshua S. Mylne,Clare Lister,Zachary B. Lippman,Robert A. Martienssen,Caroline Dean +5 more
TL;DR: It is shown that vernalization causes changes in histone methylation in discrete domains within the FLC locus, increasing dimethylation of lysines 9 and 27 on histone H3, which identify silenced chromatin states in Drosophila and human cells.
Journal ArticleDOI
WDR5 Associates with Histone H3 Methylated at K4 and Is Essential for H3 K4 Methylation and Vertebrate Development
Joanna Wysocka,Tomek Swigut,Thomas A. Milne,Yali Dou,Xin Zhang,Alma L. Burlingame,Robert G. Roeder,Ali H. Brivanlou,C. David Allis +8 more
TL;DR: The results are the first demonstration that a WD40-repeat protein acts as a module for recognition of a specific histone modification and suggest a mechanism for reading and writing an epigenetic mark for gene activation.
References
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Journal ArticleDOI
The language of covalent histone modifications.
Brian D. Strahl,C D Allis +1 more
TL;DR: It is proposed that distinct histone modifications, on one or more tails, act sequentially or in combination to form a ‘histone code’ that is, read by other proteins to bring about distinct downstream events.
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DNA methylation patterns and epigenetic memory
TL;DR: The heritability of methylation states and the secondary nature of the decision to invite or exclude methylation support the idea that DNA methylation is adapted for a specific cellular memory function in development.
Journal ArticleDOI
Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
Rudolf Jaenisch,Adrian Bird +1 more
TL;DR: Advances in the understanding of the mechanism and role of DNA methylation in biological processes are reviewed, showing that epigenetic mechanisms seem to allow an organism to respond to the environment through changes in gene expression.
Journal ArticleDOI
Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing
Ru Cao,Liangjun Wang,Hengbin Wang,Li Xia,Hediye Erdjument-Bromage,Paul Tempst,Richard S. Jones,Yi Zhang +7 more
TL;DR: The purification and characterization of an EED-EZH2 complex, the human counterpart of the Drosophila ESC-E(Z) complex, is reported, and it is demonstrated that the complex specifically methylates nucleosomal histone H3 at lysine 27 (H3-K27).
Journal ArticleDOI
Regulation of chromatin structure by site-specific histone H3 methyltransferases
Stephen Rea,Frank Eisenhaber,Dónal O'Carroll,Brian D. Strahl,Zu-Wen Sun,Manfred Schmid,Susanne Opravil,Karl Mechtler,Chris P. Ponting,C D Allis,Thomas Jenuwein +10 more
TL;DR: A functional interdependence of site-specific H3 tail modifications is revealed and a dynamic mechanism for the regulation of higher-order chromatin is suggested.