Homozygosity for the Min Allele of Apc Results in Disruption of Mouse Development Prior to Gastrulation
Amy R. Moser,Alex R. Shoemaker,Camille S. Connelly,Linda Clipson,Karen A. Gould,Cindy Luongo,William F. Dove,Pamela H. Siggers,Richard L. Gardner +8 more
TLDR
Results indicate that functional Apc is required for normal growth of inner cell mass derivatives in embryos homozygous for ApcMin (Min), and development of the primitive ectoderm fails prior to gastrulation in Homozygous Min embryos.Abstract:
Mutation of the APC (adenomatous polyposis coli) gene is an early event in colon tumor development in humans. Mice carrying Min (multiple intestinal neoplasia), a mutant allele of Apc, develop intestinal and mammary tumors as adults. To study the role of the Apc gene in development, we have investigated the phenotype of embryos homozygous for ApcMin (Min). Development of the primitive ectoderm fails prior to gastrulation in homozygous Min embryos. By midgestation, the presumed homozygotes consist of a mass of trophoblast giant cells with an additional cluster of much smaller embryonic cells. These results indicate that functional Apc is required for normal growth of inner cell mass derivatives.read more
Citations
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Caught up in a Wnt storm: Wnt signaling in cancer.
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References
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Journal ArticleDOI
Identification and characterization of the familial adenomatous polyposis coli gene
Joanna Groden,Andrew Thliveris,Andrew Thliveris,Wade S. Samowitz,M. Carlson,Lawrence Gelbert,Lawrence Gelbert,Hans Albertsen,Geoff Joslyn,Geoff Joslyn,Jeff Stevens,Jeff Stevens,Lisa Spirio,Margaret Robertson,Margaret Robertson,Leslie Sargeant,Leslie Sargeant,Karen Krapcho,Karen Krapcho,E. Wolff,E. Wolff,Randall W. Burt,John P. Hughes,Janet A. Warrington,John Douglas Mcpherson,John J. Wasmuth,Denis Le Paslier,Hadi Abderrahim,Daniel Cohen,Mark Leppert,Mark Leppert,Ray White,Ray White +32 more
TL;DR: DNA from 61 unrelated patients with adenomatous polyposis coli (APC) was examined for mutations in three genes located within a 100 kb region deleted in two of the patients, and data have established that DP2.5 is the APC gene.
Journal ArticleDOI
Clues to the pathogenesis of familial colorectal cancer
Lauri A. Aaltonen,Päivi Peltomäki,Fredrick S. Leach,Pertti Sistonen,Lea Pylkkänen,Jukka-Pekka Mecklin,Heikki Järvinen,Steven M. Powell,Jin Jen,Stanley R. Hamilton,Gloria M. Petersen,Kenneth W. Kinzler,Bert Vogelstein,Albert de la Chapelle +13 more
TL;DR: Molecular features of "familial" cancers were compared with those of sporadic colon cancers, and a mechanism for familial tumorigenesis different from that mediated by classic tumor suppressor genes is suggested.
Journal ArticleDOI
APC mutations occur early during colorectal tumorigenesis.
Steven M. Powell,Nathan Zilz,Yasmin Beazer-Barclay,Tracy M. Bryan,Stanley R. Hamilton,Stephen N. Thibodeau,Bert Vogelstein,Kenneth W. Kinzler +7 more
TL;DR: Evidence is provided that mutations of the APC gene play a major role in the early development of colorectal neoplasms, and the frequency of such mutations remained constant as tumours progressed from benign to malignant stages.
Journal ArticleDOI
Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients
Isamu Nishisho,Yusuke Nakamura,Yasuo Miyoshi,Yoshio Miki,Hiroshi Ando,Akira Horii,Kumiko Koyama,Joji Utsunomiya,Shozo Baba,Hedge Philip John,Alex Markham,Anne J. Krush,Gloria M. Petersen,Stanley R. Hamilton,Mef Nilbert,Daniel B. Levy,Tracy M. Bryan,Antonette C. Preisinger,Kelly J. Smith,Li Kuo Su,Kenneth W. Kinzler,Bert Vogelstein +21 more
TL;DR: The data suggest that more than one gene on chromosome 5q21 may contribute to colorectal neoplasia, and that mutations of the APC gene can cause both FAP and GS.
Journal ArticleDOI
Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene.
Li Kuo Su,Kenneth W. Kinzler,Bert Vogelstein,Antoinette C. Preisinger,Amy R. Moser,Cindy Luongo,Karen A. Gould,William F. Dove +7 more
TL;DR: In this paper, a mouse lineage that exhibits an autosomal dominantly inherited predisposition to multiple intestinal neoplasia (Min) was described and linkage analysis showed that the murine homolog of the APC gene (mApc) was tightly linked to the Min locus.
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