Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter
Edith C. H. Friesema,Sumita Ganguly,Amal Abdalla,Jocelyn E. Manning Fox,Andrew P. Halestrap,Theo J. Visser +5 more
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TLDR
Cloned rat MCT8 was identified as a very active and specific thyroid hormone transporter and showed high expression in liver, kidney, brain, and heart.About:
This article is published in Journal of Biological Chemistry.The article was published on 2003-10-10 and is currently open access. It has received 630 citations till now. The article focuses on the topics: Thyroid hormone transport & Amino acid transporter.read more
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Mechanisms of thyroid hormone action
TL;DR: The mechanism of thyroid hormone action and the role of local ligand availability; tissue and cell-specific thyroid hormone transporters, corepressors, and coactivators; thyroid hormone receptor (TR) isoform-specific action; and cross-talk in metabolic regulation and neural development are influenced.
Journal ArticleDOI
Cellular and Molecular Basis of Deiodinase-Regulated Thyroid Hormone Signaling
Balázs Gereben,Ann Marie Zavacki,Scott Ribich,Brian W. Kim,Stephen A. Huang,Warner S. Simonides,Anikó Zeöld,Antonio C. Bianco,Antonio C. Bianco +8 more
TL;DR: It seems clear that deiodinases play a much broader role than once thought, with great ramifications for the control of thyroid hormone signaling during vertebrate development and metamorphosis, as well as injury response, tissue repair, hypothalamic function, and energy homeostasis in adults.
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A novel syndrome combining thyroid and neurological abnormalities is associated with mutations in a monocarboxylate transporter gene.
TL;DR: For the first time, mutations in the monocarboxylate transporter 8 (MCT8) gene, located on the X chromosome, have been linked to a defect in cellular hormone transport as mentioned in this paper.
Journal ArticleDOI
Association between mutations in a thyroid hormone transporter and severe X-linked psychomotor retardation
Edith C. H. Friesema,Annette Grueters,Heike Biebermann,Heiko Krude,Arpad von Moers,Maarten Reeser,Timothy Barrett,Edna E. Mancilla,Johan Svensson,Monique H. A. Kester,George G. J. M. Kuiper,Sahila Balkassmi,André G. Uitterlinden,Josef Koehrle,Patrice Rodien,Andrew P. Halestrap,Theo J. Visser +16 more
TL;DR: It is suggested that this novel syndrome of X-linked psychomotor retardation is due to a defect in T3 entry into neurons through MCT8, resulting in impaired T3 action and metabolism.
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X-linked mental retardation
TL;DR: The remarkable recent progress in research into the genetic and molecular causes of mental retardation, its promise for understanding neural function, learning and memory, and the implications of this research for health care are reviewed.
References
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PEST sequences and regulation by proteolysis
TL;DR: Recent experimental support for the hypothesis that polypeptide sequences enriched in proline, glutamic acid, serine, and threonine target proteins for rapid destruction is provided with a number of papers providing strong evidence that PEST regions serve as proteolytic signals.
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The role of thyroid hormones in prenatal and neonatal neurological development--current perspectives.
TL;DR: It now appears that fetal thyroid hormones play an essential role in fetal brain development, and as some placental transport of thyroid hormones has been shown to occur, it is possible that maternal thyroid hormones might influence Fetal brain development.
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Plasma Membrane Transport of Thyroid Hormones and Its Role in Thyroid Hormone Metabolism and Bioavailability
Georg Hennemann,Roelof Docter,Edith C. H. Friesema,Marion de Jong,Eric P. Krenning,Theo J. Visser +5 more
TL;DR: Although it was originally believed that thyroid hormones enter target cells by passive diffusion, it is now clear that cellular uptake is effected by carrier-mediated processes and two stereospecific binding sites for each T4 and T3 have been detected in cell membranes and on intact cells from humans and other species.
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Direct demonstration of a specific interaction between cyclophilin-D and the adenine nucleotide translocase confirms their role in the mitochondrial permeability transition
TL;DR: A fusion protein between cyclophilin-D and glutathione S-transferase (GST) was shown to bind to purified liver inner mitochondrial membranes (IMMs) in a cyclosporin A (CsA)-sensitive manner and was enhanced by diamide treatment of the IMMs.
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Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past
TL;DR: The identification of new human MCT homologues in the database of expression sequence tags and the cloning and sequencing of four new full-length MCT-like sequences from human cDNA libraries are reported, which are denoted MCT3, MCT4, M CT5 and MCT6.
Related Papers (5)
Association between mutations in a thyroid hormone transporter and severe X-linked psychomotor retardation
Edith C. H. Friesema,Annette Grueters,Heike Biebermann,Heiko Krude,Arpad von Moers,Maarten Reeser,Timothy Barrett,Edna E. Mancilla,Johan Svensson,Monique H. A. Kester,George G. J. M. Kuiper,Sahila Balkassmi,André G. Uitterlinden,Josef Koehrle,Patrice Rodien,Andrew P. Halestrap,Theo J. Visser +16 more