Journal ArticleDOI
IL-6 and APPs: anti-inflammatory and immunosuppressive mediators.
TLDR
Recent data suggest that interleukin 6 (IL-6) and IL-6-regulated APPs are anti-inflammatory and immuno-suppressive, and may negatively regulate the acute phase response.About:
This article is published in Immunology Today.The article was published on 1997-09-01. It has received 646 citations till now. The article focuses on the topics: Inflammation.read more
Citations
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Journal ArticleDOI
The anti-inflammatory effect of exercise
TL;DR: It is suggested that myokines may be involved in mediating the health-beneficial effects of exercise and that these in particular are involved in the protection against chronic diseases associated with low-grade inflammation such as diabetes and cardiovascular diseases.
Journal ArticleDOI
Role of proinflammatory cytokines in the pathophysiology of osteoarthritis
TL;DR: The current knowledge regarding the role of proinflammatory cytokines in the pathophysiology of OA is discussed and the potential of anticytokine therapy in the treatment of this disease is addressed.
Journal ArticleDOI
Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly
Tamara B. Harris,Luigi Ferrucci,Russell P. Tracy,M. Chiara Corti,Sholom Wacholder,Walter H. Ettinger,Harley Heimovitz,Harvey J. Cohen,Robert B. Wallace +8 more
TL;DR: In this article, the authors investigated whether interleukin-6 and C-reactive protein levels predict all-cause and cause-specific mortality in a population-based sample of nondisabled older people.
Journal ArticleDOI
Peroxisome Proliferator-activated Receptor α Negatively Regulates the Vascular Inflammatory Gene Response by Negative Cross-talk with Transcription Factors NF-κB and AP-1
Philippe Delerive,Karolien De Bosscher,Sandrine Besnard,Wim Vanden Berghe,Jeffrey M. Peters,Frank J. Gonzalez,Jean Charles Fruchart,Alain Tedgui,Guy Haegeman,Bart Staels +9 more
TL;DR: Fibrates inhibit the vascular inflammatory response via PPARα by interfering with the NF-κB and AP-1 transactivation capacity involving direct protein-protein interaction with p65 and c-Jun.
Journal ArticleDOI
IL-6 enhances plasma IL-1ra, IL-10, and cortisol in humans
Adam Steensberg,Christian P. Fischer,Charlotte Keller,Kirsten Møller,Bente Klarlund Pedersen +4 more
TL;DR: IL-6 induces an increase in cortisol and, consequently, in neutrocytosis and late lymphopenia to the same magnitude and with the same kinetics as during exercise, suggesting that muscle-derived IL-6 has a central role in exercise-induced leukocyte trafficking.
References
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Journal ArticleDOI
The acute phase response
Heinz Baumann,Jack Gauldie +1 more
TL;DR: This review outlines the principal cellular and molecular mechanisms that control initiation of the tissue response at the site of injury, the recruitment of the systemic defense mechanisms, the acute phase response of the liver and the resolution of the acutephase response.
Journal ArticleDOI
Impaired immune and acute-phase responses in interleukin-6-deficient mice
Manfred Kopf,Heinz Baumann,Giulia Freer,Marina A. Freudenberg,Marinus C. Lamers,Tadamitsu Kishimoto,Rolf M. Zinkernagel,Horst Bluethmann,Georges Köhler +8 more
TL;DR: It is concluded that IL-6 production induced by injury or infection is an important in vivo SOS signal which coordinates activities of liver cells, macrophages and lymphocytes.
Book ChapterDOI
Interleukin-6 in biology and medicine
TL;DR: Application of IL-6 is promising in cancer treatment as well as in treatment of radiation- or chemotherapy-induced myelosuppression and the cell biology of the intracellular events that link transduction to gene regulation is an important area, and work on these topics helps to understand such phenomena as multifunction of IL -6 and bidirectional effects of cell growth depending on the cell type.
Journal ArticleDOI
Interleukin-6 family of cytokines and gp130.
TL;DR: It is shown that IL-6, together with IL-3, induces the expansion of murine hematopoietic progenitor cells and to be responsible for stimulating resting cells to enter the Cl-phase, a fact that may explain the redundant activities of IL- 6 and LIF.
Journal ArticleDOI
Correlations and interactions in the production of interleukin-6 (IL-6), IL-1, and tumor necrosis factor (TNF) in human blood mononuclear cells: IL-6 suppresses IL-1 and TNF.
Ralf Schindler,Javier Mancilla,Stefan Endres,Reza Ghorbani,Steven C. Clark,Charles A. Dinarello +5 more
TL;DR: A specific radioimmunoassay was developed and used for IL-6 to compare production of this cytokine on a molar basis with that of IL-1 alpha,IL-1 beta, and tumor necrosis factor (TNF)alpha, and there was a significant correlation betweenIL-6 and IL-2 beta (r = .72) and between IL-4 and TNF ( r = .66).