Journal ArticleDOI
Immune involvement in schizophrenia and autism: Etiology, pathology and animal models
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TLDR
The human and animal results related to immune involvement suggest novel therapeutic avenues based on immune interventions, which could help to explain some of the heterogeneity of schizophrenia.About:
This article is published in Behavioural Brain Research.The article was published on 2009-12-07. It has received 692 citations till now. The article focuses on the topics: Immune dysregulation & Autism.read more
Citations
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Journal ArticleDOI
The Microbiota-Gut-Brain Axis
John F. Cryan,Kenneth J. O’Riordan,Caitlin S. M. Cowan,Kiran V. Sandhu,Thomaz F.S. Bastiaanssen,Marcus Boehme,Martín Gabriel Codagnone,Sofia Cussotto,Christine Fülling,Anna V. Golubeva,Katherine E. Guzzetta,Minal Jaggar,Caitriona M. Long-Smith,Joshua M. Lyte,Jason A. Martin,Alicia Molinero-Perez,Gerard M. Moloney,Emanuela Morelli,Enrique Morillas,Rory C. O'Connor,Joana S Cruz-Pereira,Veronica L. Peterson,Kieran Rea,Nathaniel L. Ritz,Eoin Sherwin,Simon Spichak,Emily M. Teichman,Marcel van de Wouw,Ana Paula Ventura-Silva,Shauna E. Wallace-Fitzsimons,Niall P. Hyland,Gerard Clarke,Timothy G. Dinan +32 more
TL;DR: Future studies will focus on understanding the mechanisms underlying the microbiota-gut-brain axis and attempt to elucidate microbial-based intervention and therapeutic strategies for neuropsychiatric disorders.
Journal ArticleDOI
Animal models of neuropsychiatric disorders
Eric J. Nestler,Steven E. Hyman +1 more
TL;DR: The current state of animal models of mental illness, with a focus on schizophrenia, depression and bipolar disorder, is reviewed and it is argued for areas of focus that might increase the likelihood of creating more useful models, at least for some disorders.
Journal ArticleDOI
Prenatal Infection and Schizophrenia: A Review of Epidemiologic and Translational Studies
Alan Brown,Elena J. Derkits +1 more
TL;DR: The promise of this work for facilitating the identification of susceptibility loci in genetic studies of schizophrenia is illustrated by examples of interaction between in utero exposure to infection and genetic variants.
Journal ArticleDOI
Microglia development follows a stepwise program to regulate brain homeostasis
Orit Matcovitch-Natan,Deborah R. Winter,Amir Giladi,Stephanie Vargas Aguilar,Amit Spinrad,Sandrine Sarrazin,Sandrine Sarrazin,Sandrine Sarrazin,Hila Ben-Yehuda,Eyal David,Fabiola Zelada González,Fabiola Zelada González,Fabiola Zelada González,Pierre Perrin,Pierre Perrin,Pierre Perrin,Hadas Keren-Shaul,Meital Gury,David Lara-Astaiso,Christoph A. Thaiss,Merav Cohen,Keren Bahar Halpern,Kuti Baruch,Aleksandra Deczkowska,Erika Lorenzo-Vivas,Shalev Itzkovitz,Eran Elinav,Michael H. Sieweke,Michal Schwartz,Ido Amit +29 more
TL;DR: It is found that microglia from germ-free mice exhibited dysregulation of dozens of genes associated with the adult phase and immune response, including MAFB, which led to disruption of homeostasis in adulthood and increased expression of interferon and inflammation pathways.
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Interleukin-6, a major cytokine in the central nervous system.
TL;DR: Its expression is affected in several of the main brain diseases, and animal models strongly suggest that IL-6 could have a role in the observed neuropathology and that therefore it is a clear target of strategic therapies.
References
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Journal ArticleDOI
Neuroglial activation and neuroinflammation in the brain of patients with autism
Diana L. Vargas,Caterina Nascimbene,Caterina Nascimbene,Chitra Krishnan,Andrew W. Zimmerman,Andrew W. Zimmerman,Carlos A. Pardo +6 more
TL;DR: It is indicated that innate neuroimmune reactions play a pathogenic role in an undefined proportion of autistic patients, suggesting that future therapies might involve modifying neuroglial responses in the brain.
Journal ArticleDOI
The neuropathology of schizophrenia. A critical review of the data and their interpretation.
TL;DR: Functional imaging data indicate that the pathophysiology of schizophrenia reflects aberrant activity in, and integration of, the components of distributed circuits involving the prefrontal cortex, hippocampus and certain subcortical structures.
Journal ArticleDOI
Neuroanatomy of autism
TL;DR: It is suggested that the heterogeneity of both the core and co-morbid features predicts a heterogeneous pattern of neuropathology in autism, and defined phenotypes in larger samples of children and well-characterized brain tissue will be necessary for clarification of the neuroanatomy of autism.
Journal ArticleDOI
Maternal Immune Activation Alters Fetal Brain Development through Interleukin-6
Stephen E. P. Smith,Jennifer S. Li,Jennifer S. Li,Krassimira A. Garbett,Karoly Mirnics,Paul H. Patterson +5 more
TL;DR: It is shown that the cytokine interleukin-6 (IL-6) is critical for mediating the behavioral and transcriptional changes in the offspring and should be identified as a key intermediary in the molecular dissection of the pathways whereby MIA alters fetal brain development.
Journal ArticleDOI
Cytokines and major depression.
TL;DR: Although the central effects of proinflammatory cytokines appear to be able to account for most of the symptoms occurring in depression, it remains to be established whether cytokines play a causal role in depressive illness or represent epiphenomena without major significance.
Related Papers (5)
Prenatal Infection and Schizophrenia: A Review of Epidemiologic and Translational Studies
Alan Brown,Elena J. Derkits +1 more