Journal ArticleDOI
Immune surveillance of human cancer: If the cytotoxic T-lymphocytes play the music, does the tumoral system call the tune?
A. Hamaï,Houssem Benlalam,Franck Meslin,Meriem Hasmim,Thibault Carré,Intissar Akalay,Bassam Janji,Guy Berchem,Muhammad Zaeem Noman,Salem Chouaib +9 more
Reads0
Chats0
TLDR
New mechanisms associated with the acquisition of tumor resistance to specific lysis during tumor progression, involving genetic instability, structural changes in cytoskeleton, and hypoxic stress are focused on.Abstract:
Accumulating evidence indicates that the innate and adaptive immune systems participate in the recognition and destruction of cancer cells by a process known as cancer immunosurveillance. Tumor antigen-specific cytotoxic T-lymphocytes (CTL) are the major effectors in the immune response against tumor cells. The identification of tumor-associated antigen (TAA) recognized primarily by CD 8(+) T-lymphocytes has led to the development of several vaccination strategies that induce or potentiate specific immune responses. However, large established tumors, which are associated with the acquisition of tumor resistance to specific lysis, are usually not fully controlled by the immune system. Recently, it has become clear that the immune system not only protects the host against tumor development but also sculpts the immunogenic phenotype of a developing tumor and can favor the emergence of resistant tumor cell variants. Moreover, it has become obvious that the evasion of immunosurveillance by tumor cells is under the control of the tumor microenvironment complexity and plasticity. In this review, we will focus on some new mechanisms associated with the acquisition of tumor resistance to specific lysis during tumor progression, involving genetic instability, structural changes in cytoskeleton, and hypoxic stress. We will also discuss the interaction between CTLs and tumor endothelial cells, a major component of tumor stroma.read more
Citations
More filters
Journal ArticleDOI
Cancer-generated lactic acid: a regulatory, immunosuppressive metabolite?
Stephen Yiu Chuen Choi,Colin Collins,Colin Collins,Peter W. Gout,Yuzhuo Wang,Yuzhuo Wang,Yuzhuo Wang +6 more
TL;DR: It is proposed that the maintenance by cancers of a relatively low pH in their micro‐environment, via regulation of their lactic acid secretion through selective modification of their energy metabolism, is another major mechanism by which cancers can suppress the anti‐cancer immune response.
Journal ArticleDOI
Hypoxic stress: obstacles and opportunities for innovative immunotherapy of cancer
Salem Chouaib,Salem Chouaib,Muhammad Zaeem Noman,Muhammad Zaeem Noman,K Kosmatopoulos,Michael A. Curran +5 more
TL;DR: Current knowledge regarding the molecular mechanisms induced by tumor cell hypoxia with a special emphasis on therapeutic resistance and immune suppression are summarized and mechanisms of manipulating hypoxic stress and its associated pathways are emphasized to support the development of more durable and successful cancer immunotherapy approaches in the future.
Journal ArticleDOI
Blocking hypoxia-induced autophagy in tumors restores cytotoxic T-cell activity and promotes regression.
Muhammad Zaeem Noman,Bassam Janji,Bozena Kaminska,Kris Van Moer,Sandrine Pierson,Piotr Przanowski,Stéphanie Buart,Guy Berchem,Pedro Romero,Fathia Mami-Chouaib,Salem Chouaib +10 more
TL;DR: A novel functional link between hypoxia-induced autophagy and the regulation of antigen-specific T-cell lysis is established and points to a major role of autophagic in the control of in vivo tumor growth.
Journal ArticleDOI
Alteration of the Antitumor Immune Response by Cancer-Associated Fibroblasts.
TL;DR: The current understanding of how activated tumor-associated fibroblasts accomplish this task as well as their potential therapeutic implications are described.
Journal ArticleDOI
Autophagy regulation and its role in cancer
TL;DR: The role of the major signaling sub-networks involved in tumor progression and in regulating autophagy are discussed with regard to Beclin 1, MTOR, p53 and RAS.
References
More filters
Journal ArticleDOI
Complex networks orchestrate epithelial–mesenchymal transitions
TL;DR: Understanding how mesenchymal cells arise from an epithelial default status will also have a strong impact in unravelling the mechanisms that control fibrosis and cancer progression.
Journal ArticleDOI
Metastasis: a question of life or death
Patrick Mehlen,Alain Puisieux +1 more
TL;DR: It is stressed that the inhibition of cell death, apart from its extensively described function in primary tumour development, is a crucial characteristic of metastatic cancer cells.
Journal ArticleDOI
Hypoxia signalling in cancer and approaches to enforce tumour regression
TL;DR: There are new approaches to enforce necrotic cell death and tumour regression by targeting tumour metabolism and pHi-control systems.
Journal ArticleDOI
Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains
Grégory Bellot,Raquel Garcia-Medina,Pierre Gounon,Johanna Chiche,Danièle Roux,Jacques Pouysségur,Nathalie M. Mazure +6 more
TL;DR: A model in which the atypical BH3 domains of hypoxia-induced BNIP3/BNIP3L have been designed to induce autophagy by disrupting the Bcl-2-Beclin1 complex without inducing cell death is proposed.
Journal ArticleDOI
Apoptosis and melanoma chemoresistance.
Maria S. Soengas,Scott W. Lowe +1 more
TL;DR: The challenge is now to devise strategies potent enough to compensate or bypass these cell death defects and improve the actual poor prognosis of patients at late stages of the disease.