Journal ArticleDOI
Immunoregulatory mechanisms involved in elicitation of allergic contact hypersensitivity
Stephan Grabbe,Thomas Schwarz +1 more
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TLDR
It is proposed that the capacity of contact allergens to directly induce proinflammatory signals in the skin is of relevance and perhaps essential for elicitation of clinically manifest CHS responses.About:
This article is published in American Journal of Contact Dermatitis.The article was published on 1996-12-01. It has received 304 citations till now. The article focuses on the topics: Chemokine secretion.read more
Citations
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Reactive oxygen species, antioxidants, and the mammalian thioredoxin system.
Jonas Nordberg,Elias S.J. Arnér +1 more
TL;DR: The TrxR-catalyzed regeneration of several antioxidant compounds, including ascorbic acid (vitamin C), selenium-containing substances, lipoic acid, and ubiquinone are summarized.
Journal ArticleDOI
Skin immune sentinels in health and disease
TL;DR: This Review focuses on recent progress in dissecting the functional role of skin immune cells in skin disease and newly identified CD103+ dendritic cells are strategically positioned for cross-presentation of skin-tropic pathogens.
Journal ArticleDOI
T-cell co-stimulation through B7RP-1 and ICOS
Steven Kiyoshi Yoshinaga,John Whoriskey,Sanjay D. Khare,Ulla Sarmiento,Jane Guo,Tom Horan,Grace Shih,Ming Zhang,Marco A. Coccia,Tadahiko Kohno,Anna Tafuri-Bladt,David W. Brankow,Pauline Campbell,David Chang,Laura Chiu,Tianang Dai,Gordon S. Duncan,Gary Elliott,Ariela Hui,Susan McCabe,Sheila Scully,Arda Shahinian,Christine L. Shaklee,Gwyneth Van,Tak W. Mak,Giorgio Senaldi +25 more
TL;DR: A new murine co-stimulatory receptor–ligand pair is described that is structurally related to CD28–B7 and is involved in the adaptive immune response and defined as B7RP-1, which exhibits co- Stimulation activities in vitro and in vivo.
Journal ArticleDOI
CCL27-CCR10 interactions regulate T cell-mediated skin inflammation.
Bernhard Homey,Harri Alenius,Anja Müller,Hortensia Soto,Edward P. Bowman,Wei Yuan,Leslie McEvoy,Antti Lauerma,Till Assmann,Erich Bünemann,Maili Lehto,Henrik Wolff,David C. Yen,Heather Marxhausen,Wayne To,Jonathon D. Sedgwick,Thomas Ruzicka,Percy Lehmann,Albert Zlotnik +18 more
TL;DR: It is reported that most skin-infiltrating lymphocytes in patients suffering from psoriasis, atopic or allergic-contact dermatitis express CCR10, indicating that CCL27–CCR10 interactions have a pivotal role in T cell–mediated skin inflammation.
Journal ArticleDOI
Immune surveillance in the skin: mechanisms and clinical consequences
TL;DR: The interaction between the innate and adaptive immune systems in the skin as a model for immune function at epithelial-cell interfaces with the environment is discussed.
References
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Journal ArticleDOI
Keratinocytes as initiators of inflammation
Jonathan N.W.N. Barker,Christopher E.M. Griffiths,Brian J. Nickoloff,R. S. Mitra,Vishva M. Dixit +4 more
TL;DR: The direct activation of keratinocytes, with their ability to produce the complete repertoire of pro-inflammatory cytokines, can profoundly influence endogenous and recruited immunocompetent cells, thereby providing the critical trigger responsible for the swift and clinically dramatic alterations that occur following contact between the epidermis and a host of "noxious" agents.
Journal ArticleDOI
Early molecular events in the induction phase of contact sensitivity
Alexander Enk,Stephen I. Katz +1 more
TL;DR: It is demonstrated that Langerhans cell-derived and certain keratinocyte-derived cytokine mRNAs are selectively upregulated by allergens in the very early afferent phase of contact sensitivity.
Journal ArticleDOI
Regulation of Langerhans cell function by nerves containing calcitonin gene-related peptide
Junichi Hosoi,George F. Murphy,Christine L. Egan,Ethan A. Lerner,Stephan Grabbe,A Asahina,Richard D. Granstein +6 more
TL;DR: It is reported here that C GRP-containing nerve fibres are intimately associated with LC in human epidermis and CGRP is found at the surface of some LC and these findings indicate that CGRp may have immunomodulatory effects in vivo and suggest a locus of interaction between the nervous system and immunological function.
Journal ArticleDOI
Presentation of exogenous protein antigens by dendritic cells to T cell clones. Intact protein is presented best by immature, epidermal Langerhans cells.
Nikolaus Romani,Sumil Koide,Mary T. Crowley,Margit Witmer-Pack,Alexandra M. Livingstone,C G Fathman,Kayo Inaba,Ralph M. Steinman +7 more
TL;DR: The results suggest that dendritic cells in nonlymphoid tissues like skin can act as sentinels for presenting antigens in situ, their accessory function developing in two phases.
Journal Article
An essential role for Langerhans cell-derived IL-1 beta in the initiation of primary immune responses in skin.
TL;DR: The data indicate that dendritic cell-derived IL-1 beta may be a critical molecule required for initiation of primary immune responses in skin.
Related Papers (5)
Immunoregulatory mechanisms involved in elicitation of allergic contact hypersensitivity
Stephan Grabbe,Thomas Schwarz +1 more
Early molecular events in the induction phase of contact sensitivity
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