Impact of senescence-associated secretory phenotype and its potential as a therapeutic target for senescence-associated diseases.
TLDR
The functional and regulatory network of SASPs toward opening up new possibilities for controlling aging and aging‐associated diseases are discussed.Abstract:
'Cellular senescence' is a state in which cells undergo irreversible cell cycle arrest in response to a variety of cellular stresses. Once cells senesce, they are strongly resistant to any mitogens, including oncogenic stimuli. Therefore, cellular senescence has been assumed to be a potent anticancer mechanism. Although irreversible cell-cycle arrest is traditionally considered the major characteristic of senescent cells, recent studies have revealed some additional functions. Most noteworthy is the increased secretion of various secretory proteins, such as inflammatory cytokines, chemokines, growth factors, and matrix metalloproteinases, into the surrounding extracellular fluid. These newly recognized senescent phenotypes, termed senescence-associated secretory phenotypes (SASPs), reportedly contribute to tumor suppression, wound healing, embryonic development, and even tumorigenesis promotion. Thus, SASPs appear to be beneficial or deleterious, depending on the biological context. Since senescent cells are known to accumulate during the aging process in vivo, it is quite possible that their accumulation in aged tissues promotes age-associated functional decline and various diseases, including cancers, at least to some extent. Here, we focus on and discuss the functional and regulatory network of SASPs toward opening up new possibilities for controlling aging and aging-associated diseases. This article is protected by copyright. All rights reserved.read more
Citations
More filters
Journal ArticleDOI
Age-related differential gene expression in granulosa cells and its effects on fertility using high-throughput transcriptomics
Ying Yu,Ming Jie Zhu,Chao Wei,Jie Yang,Jingyan Song,Lei Dong,Shanshan Xiang,Liang Zhang,Y. Qiu,Fang Lian +9 more
TL;DR: Combined with basic clinical ART data and pregnancy outcomes, high-throughput transcriptome sequencing was used to provide a more intuitive and in-depth understanding of age-related reduction in ovarian function and pathogenesis of infertility with regard to chronic inflammation and oxidative stress.
Book ChapterDOI
Antioxidant properties and applications of Ophiopogon japonicus root for age-related disease
Yumi Kitahiro,Makio Shibano +1 more
TL;DR: Methanol extracts and main constituents significantly downregulated the expression of IL-6 and IL-8 and decreased IL- 6 production in a strong and concentration-dependent manner by ELISA method, suggesting that Ophiopogonis Radix can be effective for chronic inflammation associated with aging.
Journal ArticleDOI
Localization of senescent cells under cavity preparations in rats and restoration of reparative dentin formation by senolytics.
Haitao Liu,Ya'nan Gong,Masato Nakagawa,Hiroaki Tanimoto,Kazushi Yoshikawa,Yoshitomo Honda,Kazuyo Yamamoto +6 more
TL;DR: In this article , the authors established a rat model of dental cavity preparation and analyzed the spatiotemporal localization of senescent cells in the pulp and found that p21 and p16-positive cells appeared mostly around the pulp horn under DCP.
Journal ArticleDOI
Stem Cell Therapy and Rejuvenation, and Their Impact on Society
TL;DR: In his worldwide bestsellers Homo Deus as mentioned in this paper , the author describes the evolution of the human brain and its relationship with the human body, including the brain itself, and its connections.
References
More filters
Journal ArticleDOI
The serial cultivation of human diploid cell strains.
Leonard Hayflick,P.S. Moorhead +1 more
TL;DR: A consideration of the cause of the eventual degeneration of these strains leads to the hypothesis that non-cumulative external factors are excluded and that the phenomenon is attributable to intrinsic factors which are expressed as senescence at the cellular level.
Journal ArticleDOI
A biomarker that identifies senescent human cells in culture and in aging skin in vivo
Goberdhan P. Dimri,X Lee,G Basile,Meileen Acosta,G Scott,C Roskelley,E E Medrano,Maarten H.K. Linskens,Ivica Rubelj,Olivia M. Pereira-Smith +9 more
TL;DR: It is shown that several human cells express a beta-galactosidase, histochemically detectable at pH 6, upon senescence in culture, which provides in situ evidence that senescent cells may exist and accumulate with age in vivo.
Journal ArticleDOI
The limited in vitro lifetime of human diploid cell strains
TL;DR: The survival curves obtained with human diploid cell strains are comparable to “multiple-hit” or “ multiple-target” curves obtain with other biological systems where an initial threshold dose is required before an exponential form of the curve is established.
Journal ArticleDOI
Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a
TL;DR: It is shown that expression of oncogenic ras in primary human or rodent cells results in a permanent G1 arrest, and that the onset of cellular senescence does not simply reflect the accumulation of cell divisions, but can be prematurely activated in response to an onCogenic stimulus.
Journal ArticleDOI
Myofibroblasts and mechano-regulation of connective tissue remodelling
TL;DR: It is clear that the understanding of the myofibroblast — its origins, functions and molecular regulation — will have a profound influence on the future effectiveness not only of tissue engineering but also of regenerative medicine generally.