Journal ArticleDOI
Impairment of human terminal erythroid differentiation by histone deacetylase 5 deficiency.
Yaomei Wang,Yaomei Wang,Wei Li,Wei Li,Vincent P. Schulz,Huizhi Zhao,Huizhi Zhao,Xiaoli Qu,Qian Qi,Yong Cheng,Xinhua Guo,Shijie Zhang,Xin Wei,Xin Wei,Donghao Liu,Karina Yazdanbakhsh,Christopher D. Hillyer,Narla Mohandas,Lixiang Chen,Patrick G. Gallagher,Xiuli An +20 more
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TLDR
In this article, the role of histone deacetylases (HDACs) in mammalian erythropoiesis remains to be fully defined, however, it is known that HDACs have diverse functions in a wide range of biological processes.About:
This article is published in Blood.The article was published on 2021-10-28. It has received 19 citations till now. The article focuses on the topics: Chromatin & Histone deacetylase 5.read more
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SIRPα and PD1 expression on tumor-associated macrophage predict prognosis of intrahepatic cholangiocarcinoma
TL;DR: The phagocytosis checkpoints of CD47/SIRPα, PD1/PDL1, CD24/SIGLEC10, and MHC/LILRB1 have been investigated in intrahepatic cholangiocarcinoma (ICC) patients as discussed by the authors .
Journal ArticleDOI
SIRPα and PD1 expression on tumor-associated macrophage predict prognosis of intrahepatic cholangiocarcinoma
TL;DR: The phagocytosis checkpoints of CD47/SIRPα, PD1/PDL1, CD24/SIGLEC10, and MHC/LILRB1 have been investigated in intrahepatic cholangiocarcinoma (ICC) patients as mentioned in this paper .
Journal ArticleDOI
GM-CSF impairs erythropoiesis by disrupting erythroblastic island formation via macrophages
Weijie Cao,Wen-mao Fan,Fang Wang,Yinyin Zhang,Guanghua Wu,Xiaojing Shi,Jiangxiang Shi,Feng Gao,Mei-hua Yan,Rong Guo,Yingmei Li,Wei Liu,Chunyan Du,Zhongxing Jiang +13 more
TL;DR: In this article , the GM-CSF receptor is preferentially and highly expressed among EBI macrophages but not among erythroblastic island (EBI) cells.
Journal ArticleDOI
HDAC8 drives spindle organization during meiotic maturation of porcine oocytes
TL;DR: In this paper, a siRNA-targeting siRNA was microinjected into GV oocytes to deplete histone deacetylase 8 (HDAC8), which led to oocyte meiotic failure by showing reduced polar body extrusion rate.
Journal ArticleDOI
Epigenetic and Transcriptional Control of Erythropoiesis
Maeve Wells,Laurie A. Steiner +1 more
TL;DR: The epigenetic mechanisms that govern terminal erythroid maturation, and their role in human disease, are reviewed.
References
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Journal ArticleDOI
Histone acetylation in chromatin structure and transcription
TL;DR: The amino termini of histones extend from the nucleosomal core and are modified by acetyltransferases and deacetylases during the cell cycle, which may direct histone assembly and help regulate the unfolding and activity of genes.
Journal ArticleDOI
Histone deacetylases (HDACs): characterization of the classical HDAC family
Annemieke J.M. de Ruijter,Albert H. van Gennip,Huib N. Caron,Stephan Kemp,André B.P. van Kuilenburg +4 more
TL;DR: In this paper, a comprehensive overview of the structure, function and tissue distribution of members of the classical histone deacetylase (HDAC) family, in order to gain insight into the regulation of gene expression through HDAC activity is presented.
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The many roles of histone deacetylases in development and physiology: Implications for disease and therapy
TL;DR: In this article, the expression of many HDAC isoforms in eukaryotic cells raises questions about their possible specificity or redundancy, and whether they control global or specific programs of gene expression.
Journal ArticleDOI
Cloning and expression of the human erythropoietin gene.
Fu-Kuen Lin,Sidney Vaughn Suggs,C H Lin,J K Browne,Richard W. Smalling,Joan C. Egrie,Kenneth Chen,G. M. Fox,F Martin,Z Stabinsky +9 more
TL;DR: The human erythropoietin gene has been isolated from a genomic phage library by using mixed 20-mer and 17-mer oligonucleotide probes and encodes a 27-amino acid signal peptide and a 166-AMino acid mature protein with a calculated Mr of 18,399.
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Erythropoietin retards DNA breakdown and prevents programmed death in erythroid progenitor cells
TL;DR: DNA cleavage is a major component of normal erythropoiesis, and ERYthropoietin controls erythrocyte production by retarding DNA breakdown and preventing apoptosis in erythroid progenitor cells.