Journal ArticleDOI
In vivo test systems for the quantitative and qualitative analysis of the biological activity of phytoestrogens.
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TLDR
An in vivo test design for estrogenicity should include an analysis of several estrogen sensitive parameters in different estrogen sensitive tissues, and combinations of the test compound with estrogens and antiestrogens should be analyzed.About:
This article is published in Journal of Chromatography B.The article was published on 2002-09-25. It has received 63 citations till now. The article focuses on the topics: Phytoestrogens & Estrogen.read more
Citations
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Journal ArticleDOI
Phytoestrogens: a review of the present state of research.
TL;DR: The classification of phytoestrogens, methods of identi-cation, their proposed mechanisms of action and botanical sources for phy toestrogens are discussed, including research on bene⬁ts and risks.
Journal Article
The spectrum of phytoestrogens in nature: our knowledge is expanding
TL;DR: Although phytoestrogen intake as food or dietary supplements, in particular soya products and the isoflavones genistein and daidzein, has been associated with "health promoting effects", some data indicate increased disease risk.
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Dioxin induces an estrogen-like, estrogen receptor-dependent gene expression response in the murine uterus.
TL;DR: In an effort to further characterize the estrogenic activity of TCDD, a comprehensive time-course analysis of uterine gene expression was conducted using ovariectomized C57BL/6 mice, revealing a large proportion of the T CDD-mediated gene expression changes were also responsive to EE.
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Phytoestrogens in botanical dietary supplements: implications for cancer.
TL;DR: This article will attempt to sort out discrepancies between various experimental models and establish whether certain herbs possess estrogenic activity and address their mechanisms of action, clinical evidence bases, and implications for use in cancer.
Journal ArticleDOI
Estrogen-like effects of cadmium in vivo do not appear to be mediated via the classical estrogen receptor transcriptional pathway.
Imran Ali,Pauliina E. Penttinen-Damdimopoulou,Sari Mäkelä,Marika Berglund,Ulla Stenius,Agneta Åkesson,Helen Håkansson,Krister Halldin +7 more
TL;DR: The data suggest that Cd exposure induces a limited spectrum of estrogenic responses in vivo and that, in certain targets, effects of Cd might not be mediated via classical ER signaling through ERE-regulated genes.
References
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Journal ArticleDOI
Cloning of a novel receptor expressed in rat prostate and ovary.
TL;DR: It is concluded that clone 29 cDNA encodes a novel rat ER, which is suggested be named rat ERbeta to distinguish it from the previously cloned ER (ERalpha) from rat uterus.
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Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta.
George G. J. M. Kuiper,J.G. Lemmen,Bo Carlsson,J. Christopher Corton,Stephen Safe,Paul T. van der Saag,Bart van der Burg,Jan-Åke Gustafsson +7 more
TL;DR: The estrogenic activity of environmental chemicals and phytoestrogens in competition binding assays with ERα or ERβ protein, and in a transient gene expression assay using cells in which an acute estrogenic response is created by cotransfecting cultures with recombinant human ERβ complementary DNA (cDNA) in the presence of an estrogen-dependent reporter plasmid are investigated.
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Sequence and Characterization of a Coactivator for the Steroid Hormone Receptor Superfamily
TL;DR: Results indicate that SRC-1 encodes a coactivator that is required for full transcriptional activity of the steroid receptor superfamily.
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Monoclonal antibodies localize oestrogen receptor in the nuclei of target cells.
TL;DR: The development of an immunocytochemical procedure suitable for localizing oestrophilin directly in frozen tissue sections or cells from human and several non-human sources is reported.
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A two-step mechanism for the interaction of estradiol with rat uterus.
TL;DR: Evidence is presented that the 9.5S receptor is extranuclear and involved in estrogen uptake, whereas the nuclear 5S complex, probably responsible for hormone retention and growth initiation, is formed from the 9-5S complex by a process which consumes 9.