Incidence of influenza virus infections confirmed by serology in children and adult in a suburb community, northern China, 2018‐2019 influenza season
Cuiling Xu,Ling Liu,Binzhi Ren,Libo Dong,Shumei Zou,Weijuan Huang,Hejiang Wei,Yanhui Cheng,Jing Tang,Rongbao Gao,Lizhong Feng,Ruifu Zhang,Chaopu Yuan,Dayan Wang,Jing Chen +14 more
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In mainland China, seasonal influenza disease burden at community level is unknown and the incidence rate of influenza virus infections in the community is difficult to determine due to the lack of well‐defined catchment populations of influenza‐like illness surveillance sentinel hospitals.Abstract:
Background In mainland China, seasonal influenza disease burden at community level is unknown. The incidence rate of influenza virus infections in the community is difficult to determine due to the lack of well-defined catchment populations of influenza-like illness surveillance sentinel hospitals. Objectives We established a community-based cohort to estimate incidence of seasonal influenza infections indicated by serology and protection conferred by antibody titers against influenza infections during 2018-2019 influenza season in northern China. Methods We recruited participants in November 2018 and conducted follow-up in May 2019 with collection of sera every survey. Seasonal influenza infections were indicated by a 4-fold or greater increase of hemagglutination inhibition (HI) antibody between paired sera. Results Two hundred and three children 5-17 years of age and 413 adults 18-59 years of age were followed up and provided paired sera. The overall incidence of seasonal influenza infection and incidence of A(H3N2) infection in children (31% and 17%, respectively) were significantly higher than those in adults (21% and 10%, respectively). The incidences of A(H1N1)pdm09 infection in children and adults were both about 10%, while the incidences of B/Victoria and/Yamagata infection in children and adults were from 2% to 4%. HI titers of 1:40 against A(H1N1)pdm09 and A(H3N2) viruses were associated with 63% and 75% protection against infections with the two subtypes, respectively. Conclusions In the community, we identified considerable incidence of seasonal influenza infections. A HI titer of 1:40 could be sufficient to provide 50% protection against influenza A virus infections indicated by serology.read more
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Estimated global mortality associated with the first 12 months of 2009 pandemic influenza A H1N1 virus circulation: a modelling study
Fatimah S. Dawood,A. Danielle Iuliano,Carrie Reed,Martin I. Meltzer,David K. Shay,Po Yung Cheng,Don Bandaranayake,Robert F. Breiman,W. Abdullah Brooks,W. Abdullah Brooks,Philippe Buchy,Daniel R. Feikin,Karen B. Fowler,Aubree Gordon,Aubree Gordon,Nguyen Tran Hien,Peter Horby,Q. Sue Huang,Mark A. Katz,Anand Krishnan,Renu B. Lal,Joel M. Montgomery,Kåre Mølbak,Richard Pebody,Anne M. Presanis,Hugo Razuri,Anneke Steens,Yeny Tinoco,Jacco Wallinga,Hongjie Yu,Sirenda Vong,Joseph S. Bresee,Marc-Alain Widdowson +32 more
TL;DR: The global number of deaths during the first 12 months of virus circulation in each country and the estimate of respiratory and cardiovascular mortality associated with the 2009 pandemic influenza A H1N1 was 15 times higher than reported laboratory-confirmed deaths.
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The role of serum haemagglutination-inhibiting antibody in protection against challenge infection with influenza A2 and B viruses.
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Incidence of 2009 pandemic influenza A H1N1 infection in England: a cross-sectional serological study
TL;DR: Around one child in every three was infected with 2009 pandemic H1N1 in the first wave of infection in regions with a high incidence, ten times more than estimated from clinical surveillance.
Journal ArticleDOI
Comparative community burden and severity of seasonal and pandemic influenza: results of the Flu Watch cohort study
Andrew Hayward,Ellen Fragaszy,Ellen Fragaszy,Alison Bermingham,Lili Wang,Andrew Copas,W. John Edmunds,Neil M. Ferguson,Nilu Goonetilleke,Nilu Goonetilleke,Gabrielle Harvey,Jana Kovar,Megan S. C. Lim,Megan S. C. Lim,Andrew J. McMichael,Elizabeth R C Millett,Elizabeth R C Millett,Jonathan S. Nguyen-Van-Tam,Irwin Nazareth,Richard Pebody,Faiza Tabassum,John M Watson,Fatima Wurie,Anne M Johnson,Maria Zambon +24 more
TL;DR: The community burden and severity of seasonal and pandemic influenza across different age groups and study years are compared to gain insight into the extent to which traditional surveillance underestimates this burden.