Influenza virus hemagglutinin stalk-based antibodies and vaccines.
Florian Krammer,Peter Palese +1 more
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TLDR
Broadly protective vaccine candidates based on the epitopes of these antibodies, for example, chimeric and headless hemagglutinin structures, are under development and show promising results in animals models, and could be developed into universal influenza virus vaccines that protect from infection with drifted seasonal as well as novel pandemic influenza virus strains therefore obviating the need for annual vaccination, and enhancing pandemic preparedness.About:
This article is published in Current Opinion in Virology.The article was published on 2013-10-01 and is currently open access. It has received 301 citations till now. The article focuses on the topics: Influenza A virus & H5N1 genetic structure.read more
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Developing Recombinant Antibodies by Phage Display Against Infectious Diseases and Toxins for Diagnostics and Therapy.
Kristian Daniel Ralph Roth,Esther Veronika Wenzel,Maximilian Ruschig,Stephan Steinke,Nora Langreder,Philip Alexander Heine,Kai-Thomas Schneider,Rico Ballmann,Viola Fühner,Philipp Kuhn,Thomas Schirrmann,André Frenzel,Stefan Dübel,Maren Schubert,Gustavo Marçal Schmidt Garcia Moreira,Federico Bertoglio,Giulio Russo,Michael Hust +17 more
TL;DR: An overview of phage display derived recombinant antibodies against bacterial, viral and eukaryotic pathogens, as well as microbial toxins, intended for diagnostic and therapeutic applications is presented in this paper.
Journal ArticleDOI
Cryo-electron Microscopy Structures of Chimeric Hemagglutinin Displayed on a Universal Influenza Vaccine Candidate
Erin E. H. Tran,Kira A. Podolsky,Alberto Bartesaghi,Oleg Kuybeda,Giovanna Grandinetti,Teddy John Wohlbold,Gene S. Tan,Raffael Nachbagauer,Peter Palese,Florian Krammer,Sriram Subramaniam +10 more
TL;DR: The first three-dimensional visualization of chimeric hemagglutinin proteins displayed on the surface of the influenza virus is reported, showing that a large range of structural plasticity can be tolerated in the chimeric spike scaffold without disrupting structural and geometric aspects of antibody binding.
Journal ArticleDOI
Host Immunological Factors Enhancing Mortality of Young Adults during the 1918 Influenza Pandemic
TL;DR: Multiple mechanisms likely contributed to the increased young adult mortality in 1918 and are the focus of this review.
Journal ArticleDOI
Synthetic Toll-Like Receptor 4 (TLR4) and TLR7 Ligands Work Additively via MyD88 To Induce Protective Antiviral Immunity in Mice.
Peter H. Goff,Tomoko Hayashi,Wenqian He,Shiyin Yao,Howard B. Cottam,Gene S. Tan,Brian Crain,Florian Krammer,Karen Messer,Minya Pu,Dennis A. Carson,Peter Palese,Maripat Corr +12 more
TL;DR: It is demonstrated that several dose combinations of synthetic TLR4 and TLR7 ligands are potent adjuvants for recombinant influenza virus hemagglutinin antigen induction of humoral and cellular immunity against viral challenges.
Journal ArticleDOI
Broadly protective anti-hemagglutinin stalk antibodies induced by live attenuated influenza vaccine expressing chimeric hemagglutinin.
Irina Isakova-Sivak,Daniil Korenkov,Tatiana Smolonogina,Tatiana Kotomina,Donina Sa,Victoria Matyushenko,Daria Mezhenskaya,Florian Krammer,Larisa Rudenko +8 more
TL;DR: The establishment of fully functional cross-protective immunity after two doses of cHA LAIV vaccination in naïve animals suggests that a similar effect might be expected after a single cHALAIV dose in primed individuals, or after two to three doses in naïve children.
References
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Human Infection with a Novel Avian-Origin Influenza A (H7N9) Virus
Rongbao Gao,Bin Cao,Yunwen Hu,Zijian Feng,Dayan Wang,Wanfu Hu,Jian Chen,Zhijun Jie,Haibo Qiu,Ke Xu,Xuewei Xu,Hongzhou Lu,Wenfei Zhu,Zhancheng Gao,Nijuan Xiang,Yinzhong Shen,Zebao He,Y. Gu,Zhiyong Zhang,Yi Yang,Xiang Zhao,Lei Zhou,Xiaodan Li,Shumei Zou,Ye Zhang,Xiyan Li,Lei Yang,Junfeng Guo,Jie Dong,Qun Li,Libo Dong,Yun Zhu,Tian Bai,Shiwen Wang,Pei Hao,Weizhong Yang,Yanping Zhang,Jun Han,Hongjie Yu,Dexin Li,George F. Gao,Guizhen Wu,Yu Wang,Zhenghong Yuan,Yuelong Shu +44 more
TL;DR: Novel reassortant H7N9 viruses were associated with severe and fatal respiratory disease in three patients, and all three patients died.
Journal ArticleDOI
Antibody Recognition of a Highly Conserved Influenza Virus Epitope
Damian C. Ekiert,Gira Bhabha,Marc-André Elsliger,Robert H. E. Friesen,Mandy Jongeneelen,Mark Throsby,Jaap Goudsmit,Ian A. Wilson +7 more
TL;DR: TheCR6261 epitope identified here should accelerate the design and implementation of improved vaccines that can elicit CR6261-like antibodies, as well as antibody-based therapies for the treatment of influenza.
Journal ArticleDOI
Structural and Functional Bases for Broad-Spectrum Neutralization of Avian and Human Influenza A Viruses
Jianhua Sui,William C. Hwang,Sandra Elizabeth Pérez,Ge Wei,Daniel Aird,Li-Mei Chen,Eugenio Santelli,Boguslaw Stec,Greg Cadwell,Maryam Ali,Hongquan Wan,Akikazu Murakami,Anuradha Yammanuru,Thomas Han,Nancy J. Cox,Laurie A. Bankston,Ruben O. Donis,Robert C. Liddington,Wayne A. Marasco +18 more
TL;DR: The crystal structure of one such nAb bound to H5 shows that it blocks infection by inserting its heavy chain into a conserved pocket in the stem region, thus preventing membrane fusion, and suggests that nAb-based immunotherapy is a promising strategy for broad-spectrum protection against seasonal and pandemic influenza viruses.
Journal ArticleDOI
A neutralizing antibody selected from plasma cells that binds to group 1 and group 2 influenza A hemagglutinins
Davide Corti,Jarrod Voss,Steven J. Gamblin,Giosiana Codoni,Annalisa Macagno,David Jarrossay,Sebastien G. Vachieri,Debora Pinna,Andrea Minola,Fabrizia Vanzetta,Chiara Silacci,Blanca Fernandez-Rodriguez,Gloria Agatic,Siro Bianchi,Isabella Giacchetto-Sasselli,Lesley J. Calder,Federica Sallusto,Patrick J. Collins,Lesley F. Haire,Nigel J. Temperton,Johannes P. M. Langedijk,John J. Skehel,Antonio Lanzavecchia +22 more
TL;DR: An antibody able to broadly neutralize both group 1 and group 2 influenza A viruses—and its target epitope—are identified and may be used for passive protection and to inform vaccine design because of its broad specificity and neutralization potency.
Journal ArticleDOI
Rapid cloning of high-affinity human monoclonal antibodies against influenza virus
Jens Wrammert,Kenneth J. Smith,Joseph I. Miller,William A. Langley,Kenneth E. Kokko,Christian P. Larsen,Nai-Ying Zheng,Israel Mays,Lori Garman,Christina Helms,Judith A. James,Judith A. James,Gillian M. Air,J. Donald Capra,J. Donald Capra,Rafi Ahmed,Patrick C. Wilson,Patrick C. Wilson +17 more
TL;DR: The panel of influenza-virus-specific human mAbs allowed us to address the issue of original antigenic sin (OAS): the phenomenon where the induced antibody shows higher affinity to a previously encountered influenza virus strain compared with the virus strain present in the vaccine.
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