Influenza virus hemagglutinin stalk-based antibodies and vaccines.
Florian Krammer,Peter Palese +1 more
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TLDR
Broadly protective vaccine candidates based on the epitopes of these antibodies, for example, chimeric and headless hemagglutinin structures, are under development and show promising results in animals models, and could be developed into universal influenza virus vaccines that protect from infection with drifted seasonal as well as novel pandemic influenza virus strains therefore obviating the need for annual vaccination, and enhancing pandemic preparedness.About:
This article is published in Current Opinion in Virology.The article was published on 2013-10-01 and is currently open access. It has received 301 citations till now. The article focuses on the topics: Influenza A virus & H5N1 genetic structure.read more
Citations
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A Computationally Designed Hemagglutinin Stem-Binding Protein Provides In Vivo Protection from Influenza Independent of a Host Immune Response.
Merika Treants Koday,Jorgen Nelson,Aaron Chevalier,Michael Koday,Hannah Kalinoski,Lance Stewart,Lauren Carter,Travis Nieusma,Peter Lee,Andrew B. Ward,Ian A. Wilson,Ashley Dagley,Donald F. Smee,David Baker,Deborah H. Fuller +14 more
TL;DR: It is shown that intranasal delivery of HB36.6 affords protection in mice lethally challenged with diverse strains of influenza independent of Fc-mediated effector functions or a host antiviral immune response, and the potential of computationally designed binding proteins as a new class of antivirals for influenza is demonstrated.
Journal ArticleDOI
Broad Hemagglutinin-Specific Memory B Cell Expansion by Seasonal Influenza Virus Infection Reflects Early-Life Imprinting and Adaptation to the Infecting Virus.
Brenda L Tesini,Preshetha Kanagaiah,Jiong Wang,Megan Hahn,Jessica L. Halliley,Francisco A. Chaves,Phuong Thanh Nguyen,Aitor Nogales,Marta L. DeDiego,Christopher S. Anderson,Ali H. Ellebedy,Shirin Strohmeier,Florian Krammer,Hongmei Yang,Sanjukta Bandyopadhyay,Rafi Ahmed,John J. Treanor,Luis Martinez-Sobrido,Hana Golding,Surender Khurana,Martin S. Zand,David J. Topham,Mark Y. Sangster +22 more
TL;DR: H3-reactive MBC expansion following H3N2 infection is consistent with maintenance of response patterns established early in life, but nevertheless includes MBC adaptation to the infecting virus.
Journal ArticleDOI
Influenza virus-specific antibody dependent cellular cytoxicity induced by vaccination or natural infection
Rory D. de Vries,Nella J. Nieuwkoop,Mark Pronk,Erwin de Bruin,Geert Leroux-Roels,Elisabeth G. W. Huijskens,Rob van Binnendijk,Florian Krammer,Marion Koopmans,Guus F. Rimmelzwaan +9 more
TL;DR: This assay will facilitate the assessment of ADCC mediating serum antibodies after (universal) influenza vaccination or infection and may define ADCC activity as a correlate of (cross-) protection in the future.
Journal ArticleDOI
Original antigenic sin priming of influenza virus hemagglutinin stalk antibodies.
Claudia P. Arevalo,Valerie Le Sage,Marcus J. Bolton,Theresa Eilola,Jennifer Jones,Karen A. Kormuth,Eric Nturibi,Angel Balmaseda,Aubree Gordon,Seema S. Lakdawala,Scott E. Hensley +10 more
TL;DR: The results demonstrate that an individual’s HA stalk antibody response is dependent on the specific subtype of influenza virus that they first encounter early in life, and propose that humans are susceptible to heterosubtypic influenza virus infections later in life.
Journal ArticleDOI
Long-Lasting Cross-Protection Against Influenza A by Neuraminidase and M2e-based immunization strategies.
Michael Schotsaert,Tine Ysenbaert,Anouk Smet,Bert Schepens,Dieter Vanderschaeghe,Svetlana Stegalkina,Thorsten U. Vogel,Nico Callewaert,Walter Fiers,Xavier Saelens +9 more
TL;DR: NA- and M2e-based immunity can protect against challenge with (homologous) virus without compromising the induction of robust cross-reactive CD8+ T cell responses upon exposure to virus.
References
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Human Infection with a Novel Avian-Origin Influenza A (H7N9) Virus
Rongbao Gao,Bin Cao,Yunwen Hu,Zijian Feng,Dayan Wang,Wanfu Hu,Jian Chen,Zhijun Jie,Haibo Qiu,Ke Xu,Xuewei Xu,Hongzhou Lu,Wenfei Zhu,Zhancheng Gao,Nijuan Xiang,Yinzhong Shen,Zebao He,Y. Gu,Zhiyong Zhang,Yi Yang,Xiang Zhao,Lei Zhou,Xiaodan Li,Shumei Zou,Ye Zhang,Xiyan Li,Lei Yang,Junfeng Guo,Jie Dong,Qun Li,Libo Dong,Yun Zhu,Tian Bai,Shiwen Wang,Pei Hao,Weizhong Yang,Yanping Zhang,Jun Han,Hongjie Yu,Dexin Li,George F. Gao,Guizhen Wu,Yu Wang,Zhenghong Yuan,Yuelong Shu +44 more
TL;DR: Novel reassortant H7N9 viruses were associated with severe and fatal respiratory disease in three patients, and all three patients died.
Journal ArticleDOI
Antibody Recognition of a Highly Conserved Influenza Virus Epitope
Damian C. Ekiert,Gira Bhabha,Marc-André Elsliger,Robert H. E. Friesen,Mandy Jongeneelen,Mark Throsby,Jaap Goudsmit,Ian A. Wilson +7 more
TL;DR: TheCR6261 epitope identified here should accelerate the design and implementation of improved vaccines that can elicit CR6261-like antibodies, as well as antibody-based therapies for the treatment of influenza.
Journal ArticleDOI
Structural and Functional Bases for Broad-Spectrum Neutralization of Avian and Human Influenza A Viruses
Jianhua Sui,William C. Hwang,Sandra Elizabeth Pérez,Ge Wei,Daniel Aird,Li-Mei Chen,Eugenio Santelli,Boguslaw Stec,Greg Cadwell,Maryam Ali,Hongquan Wan,Akikazu Murakami,Anuradha Yammanuru,Thomas Han,Nancy J. Cox,Laurie A. Bankston,Ruben O. Donis,Robert C. Liddington,Wayne A. Marasco +18 more
TL;DR: The crystal structure of one such nAb bound to H5 shows that it blocks infection by inserting its heavy chain into a conserved pocket in the stem region, thus preventing membrane fusion, and suggests that nAb-based immunotherapy is a promising strategy for broad-spectrum protection against seasonal and pandemic influenza viruses.
Journal ArticleDOI
A neutralizing antibody selected from plasma cells that binds to group 1 and group 2 influenza A hemagglutinins
Davide Corti,Jarrod Voss,Steven J. Gamblin,Giosiana Codoni,Annalisa Macagno,David Jarrossay,Sebastien G. Vachieri,Debora Pinna,Andrea Minola,Fabrizia Vanzetta,Chiara Silacci,Blanca Fernandez-Rodriguez,Gloria Agatic,Siro Bianchi,Isabella Giacchetto-Sasselli,Lesley J. Calder,Federica Sallusto,Patrick J. Collins,Lesley F. Haire,Nigel J. Temperton,Johannes P. M. Langedijk,John J. Skehel,Antonio Lanzavecchia +22 more
TL;DR: An antibody able to broadly neutralize both group 1 and group 2 influenza A viruses—and its target epitope—are identified and may be used for passive protection and to inform vaccine design because of its broad specificity and neutralization potency.
Journal ArticleDOI
Rapid cloning of high-affinity human monoclonal antibodies against influenza virus
Jens Wrammert,Kenneth J. Smith,Joseph I. Miller,William A. Langley,Kenneth E. Kokko,Christian P. Larsen,Nai-Ying Zheng,Israel Mays,Lori Garman,Christina Helms,Judith A. James,Judith A. James,Gillian M. Air,J. Donald Capra,J. Donald Capra,Rafi Ahmed,Patrick C. Wilson,Patrick C. Wilson +17 more
TL;DR: The panel of influenza-virus-specific human mAbs allowed us to address the issue of original antigenic sin (OAS): the phenomenon where the induced antibody shows higher affinity to a previously encountered influenza virus strain compared with the virus strain present in the vaccine.
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