Journal ArticleDOI
Inhibition of Influenza Virus Infection by Multivalent Sialic‐Acid‐Functionalized Gold Nanoparticles
Ilona Papp,Christian Sieben,Kai Ludwig,Meike Roskamp,Christoph Böttcher,Sabine Schlecht,Andreas Herrmann,Rainer Haag +7 more
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TLDR
An efficient synthesis of sialic-acid-terminated glycerol dendron to chemically functionalize 2 nm and 14 nm gold nanoparticles (AuNPs) is described, which allows a new type of molecular-imaging activity-correlation and is of particular relevance for further application in alternative antiviral therapy.Abstract:
An efficient synthesis of sialic-acid-terminated glycerol dendron to chemically functionalize 2 nm and 14 nm gold nanoparticles (AuNPs) is described. These nanoparticles are highly stable and show high activity towards the inhibition of influenza virus infection. As the binding of the viral fusion protein hemagglutinin to the host cell surface is mediated by sialic acid receptors, a multivalent interaction with sialic-acid-functionalized AuNPs is expected to competitively inhibit viral infection. Electron microscopy techniques and biochemical analysis show a high binding affinity of the 14 nm AuNPs to hemagglutinin on the virus surface and, less efficiently, to isolated hemagglutinin. The functionalized AuNPs are nontoxic to the cells under the conditions studied. This approach allows a new type of molecular-imaging activity-correlation and is of particular relevance for further application in alternative antiviral therapy.read more
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The golden age: gold nanoparticles for biomedicine
TL;DR: It is argued that gold nanotechnology-enabled biomedicine is not simply an act of 'gilding the (nanomedicinal) lily', but that a new 'Golden Age' of biomedical nanotechnology is truly upon us.
Journal ArticleDOI
Multivalency as a chemical organization and action principle.
Carlo Fasting,Christoph A. Schalley,Marcus Weber,Oliver Seitz,Stefan Hecht,Beate Koksch,Jens Dernedde,Christina Graf,Ernst-Walter Knapp,Rainer Haag +9 more
TL;DR: In a systematic review of scaffold architectures, the underlying effects and control options will be demonstrated, and suggestions will be given for designing effective multivalent binding systems, as well as for polyvalent therapeutics.
Journal ArticleDOI
Silver Nanoparticles as Potential Antiviral Agents
Stefania Galdiero,Annarita Falanga,Mariateresa Vitiello,Marco Cantisani,Veronica Marra,Massimiliano Galdiero +5 more
TL;DR: The present review focuses on the development of methods for the production of silver nanoparticles and on their use as antiviral therapeutics against pathogenic viruses.
Journal ArticleDOI
Intrinsic therapeutic applications of noble metal nanoparticles: past, present and future
Rochelle R. Arvizo,Sanjib Bhattacharyya,Rachel A. Kudgus,Karuna Giri,Resham Bhattacharya,Priyabrata Mukherjee +5 more
TL;DR: This critical review will discuss the various clinical applications of gold, silver and platinum nanoparticles with relevance to above parameters and mention various routes of synthesis of these noble metal nanoparticles.
Journal ArticleDOI
Toward Nanotechnology-Enabled Approaches against the COVID-19 Pandemic.
Carsten Weiss,Marie Carrière,Laura Fusco,Laura Fusco,Ilaria Capua,Jose Angel Regla-Nava,Matteo Pasquali,James A. Scott,Flavia Vitale,Flavia Vitale,Mehmet Ünal,Cecilia Mattevi,Davide Bedognetti,Arben Merkoçi,Arben Merkoçi,Ennio Tasciotti,Ennio Tasciotti,Açelya Yilmazer,Yury Gogotsi,Francesco Stellacci,Lucia Gemma Delogu +20 more
TL;DR: Nanoimmunity by design can help to design materials for immune modulation, either stimulating or suppressing the immune response, which would find applications in the context of vaccine development for SARS-CoV-2 or in counteracting the cytokine storm, respectively.
References
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Journal ArticleDOI
Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology.
TL;DR: A review of gold nanoparticles can be found in this article, where the most stable metal nanoparticles, called gold colloids (AuNPs), have been used for catalysis and biology applications.
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Nanoparticles with Raman Spectroscopic Fingerprints for DNA and RNA Detection
TL;DR: Six dissimilar DNA targets with six Raman-labeled nanoparticle probes were distinguished, as well as two RNA targets with single nucleotide polymorphisms, and the current unoptimized detection limit of this method is 20 femtomolar.
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Receptor Binding and Membrane Fusion in Virus Entry: The Influenza Hemagglutinin
John J. Skehel,Don C. Wiley +1 more
TL;DR: Comparisons to the soluble N-ethyl-maleimide-sensitive factor attachment protein receptor (SNARE) protein complex of vesicle fusion suggests that these molecules are all in the fusion-activated conformation and that the juxtaposition of the membrane anchor and fusion peptide, a recurring feature, is involved in the fused mechanism.
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Cytotoxicity of Nanoparticles
TL;DR: For nanoparticles to move into the clinical arena, it is important that nanotoxicology research uncovers and understands how these multiple factors influence the toxicity of nanoparticles so that their undesirable properties can be avoided.
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Gold nanoparticles in nanomedicine: preparations, imaging, diagnostics, therapies and toxicity
Elodie Boisselier,Didier Astruc +1 more
TL;DR: This critical review provides an overall survey of the basic concepts and up-to-date literature results concerning the very promising use of gold nanoparticles (AuNPs) for medicinal applications.