Journal ArticleDOI
iNOS-mediated nitric oxide production and its regulation.
Reads0
Chats0
TLDR
The prevention of the overproduction of NO in the living organism through control of regulatory pathways may assist in the treatment of high NO-mediated disorders without changing physiological levels of NO.About:
This article is published in Life Sciences.The article was published on 2004-06-25. It has received 1170 citations till now. The article focuses on the topics: Nitric oxide synthase & Cofactor binding.read more
Citations
More filters
Journal ArticleDOI
Metabolic Pathways in Immune Cell Activation and Quiescence
Erika L. Pearce,Edward J. Pearce +1 more
TL;DR: This area will be the subject of this review, given that metabolic commitment is influenced not only by substrate availability but also by signaling pathways elicited by metabolites.
Journal ArticleDOI
The Cell Biology of Phagocytosis
TL;DR: Current knowledge of the cellular and molecular basis of phagosome formation and maturation is summarized and the manner in which phagocytosis is subverted by certain pathogens is discussed.
Journal ArticleDOI
Metabolic Reprograming in Macrophage Polarization
TL;DR: Studying the metabolism of immune cells in recent years has emphasized the tight link existing between the metabolic state and the phenotype of these cells, and the potential to target these events and impact on disease is an exciting prospect.
Journal ArticleDOI
Comparative antioxidant and anti-inflammatory effects of [6]-gingerol, [8]-gingerol, [10]-gingerol and [6]-shogaol.
Swarnalatha Dugasani,Mallikarjuna Rao Pichika,Vishna Devi Nadarajah,Madhu Katyayani Balijepalli,Satyanarayana Tandra,Jayaveera Narsimha Korlakunta +5 more
TL;DR: 6-Shogaol has exhibited the most potent antioxidant and anti-inflammatory properties which can be attributed to the presence of alpha,beta-unsaturated ketone moiety, and this study justifies the use of dry ginger in traditional systems of medicine.
Journal ArticleDOI
Active Nanodiamond Hydrogels for Chemotherapeutic Delivery
TL;DR: Doxorubicin hydrochloride (DOX), an apoptosis-inducing drug widely used in chemotherapy, was successfully applied toward the functionalization of nanodiamond materials (NDs) and introduced toward murine macrophages as well as human colorectal carcinoma cells with preserved efficacy.
References
More filters
Journal ArticleDOI
Nitric oxide synthases: structure, function and inhibition
TL;DR: This review concentrates on advances in nitric oxide synthase (NOS) structure, function and inhibition made in the last seven years, during which time substantial advances have been made in the authors' understanding of this enzyme family.
Journal ArticleDOI
Nitric oxide and the immune response
TL;DR: Its striking inter- and intracellular signaling capacity makes it extremely difficult to predict the effect of NOS inhibitors and NO donors, which still hampers therapeutic applications.
Journal ArticleDOI
Mammalian nitric oxide synthases.
TL;DR: This report summarizes some of the current information regarding NO synthase structure-function, reaction mechanism, control of catalysis, and protein interactions.
Journal ArticleDOI
Activation of proliferator-activated receptors alpha and gamma induces apoptosis of human monocyte-derived macrophages.
Giulia Chinetti,S. Griglio,M. Antonucci,Inés Pineda Torra,Philippe Delerive,Zouher Majd,Jean-Charles Fruchart,John Chapman,Jamila Najib,Bart Staels +9 more
TL;DR: It is shown that the PPARα and PPARγ forms are expressed in differentiated human monocyte-derived macrophages, which participate in inflammation control and atherosclerotic plaque formation and demonstrate a novel function of PPAR in human macrophage with likely consequences in inflammation and Atherosclerosis.
Journal ArticleDOI
Oxidative stress and nuclear factor-kappaB activation: a reassessment of the evidence in the light of recent discoveries.
TL;DR: It is demonstrated that much of the evidence for the involvement of oxidative stress is either specific to a stimulus in a particular cell line or open to reinterpretation, and that other evidence suggests a role for lipid peroxides in pathways where such a role exists.