Journal ArticleDOI
Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm.
Peter E. Wright,H. Jane Dyson +1 more
TLDR
Many proteins that lack intrinsic globular structure under physiological conditions have now been recognized, and it appears likely that their rapid turnover, aided by their unstructured nature in the unbound state, provides a level of control that allows rapid and accurate responses of the cell to changing environmental conditions.About:
This article is published in Journal of Molecular Biology.The article was published on 1999-10-22. It has received 2804 citations till now. The article focuses on the topics: Protein structure function & Intrinsically disordered proteins.read more
Citations
More filters
Journal ArticleDOI
Natively unfolded proteins.
TL;DR: New algorithms have been developed to identify disordered regions of proteins and have demonstrated their presence in cancer-associated proteins and proteins regulated by phosphorylation.
Journal ArticleDOI
Analysis of molecular recognition features (MoRFs).
Amrita Mohan,Christopher J. Oldfield,Predrag Radivojac,Vladimir Vacic,Marc S. Cortese,A. Keith Dunker,Vladimir N. Uversky,Vladimir N. Uversky +7 more
TL;DR: The development of a database of MoRFs derived from the RCSB Protein Data Bank is described and preliminary results of bioinformatics analyses of these sequences are presented, suggesting that functionally significant residual structure can exist in MoRF regions prior to the actual binding event.
Journal ArticleDOI
Intrinsic Disorder and Functional Proteomics
Predrag Radivojac,Lilia M. Iakoucheva,Christopher J. Oldfield,Zoran Obradovic,Vladimir N. Uversky,Vladimir N. Uversky,A. Keith Dunker +6 more
TL;DR: The recent advances in the prediction of intrinsically disordered proteins and the use of protein disorder prediction in the fields of molecular biology and bioinformatics are reviewed here, especially with regard to protein function.
Journal ArticleDOI
Structural biology of hepatitis C virus
TL;DR: Structural analyses of HCV components provide an essential framework for understanding of the molecular mechanisms ofHCV polyprotein processing, RNA replication, and virion assembly and may contribute to a betterUnderstanding of the pathogenesis of hepatitis C.
Journal ArticleDOI
The unfoldomics decade: an update on intrinsically disordered proteins
A. Keith Dunker,Christopher J. Oldfield,Jingwei Meng,Pedro Romero,Jack Y. Yang,Jessica Walton Chen,Vladimir Vacic,Zoran Obradovic,Vladimir N. Uversky,Vladimir N. Uversky +9 more
TL;DR: The goal is to review the key discoveries and to weave these discoveries together to support novel approaches for understanding sequence-function relationships.
References
More filters
Journal ArticleDOI
The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases
TL;DR: It is demonstrated that p300/CBP acetylates nucleosomes in concert with PCAF, a novel class of acetyltransferases in that it does not have the conserved motif found among various other acetyl transferases.
Journal ArticleDOI
The Structural Basis of Estrogen Receptor/Coactivator Recognition and the Antagonism of This Interaction by Tamoxifen
Andrew K. Shiau,Danielle Barstad,Paula M. Loria,Lin Cheng,Peter J. Kushner,David A. Agard,Geoffrey L. Greene +6 more
TL;DR: Crystal structures of the human estrogen receptor alpha (hER alpha) ligand-binding domain (LBD) and the OHT-LBD complex reveal the two distinct mechanisms by which structural features of OHT promote this "autoinhibitory" helix 12 conformation.
Journal ArticleDOI
Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 Å resolution
TL;DR: The X-ray crystal structure of a core synaptic fusion complex containing syntaxin-1A, synaptobrevin-II and SNAP-25B reveals a highly twisted and parallel four-helix bundle that differs from the bundles described for the haemagglutinin and HIV/SIV gp41 membrane-fusion proteins.
Journal ArticleDOI
Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins.
Keh-Ming Pan,Michael J. Baldwin,J Nguyen,María Gasset,Ana Serban,Darlene Groth,Ingrid Mehlhorn,Ziwei Huang,Robert J. Fletterick,Fred E. Cohen +9 more
TL;DR: It is argued that the conversion of alpha-helices into beta-sheets underlies the formation of PrPSc, and it is likely that this conformational transition is a fundamental event in the propagation of prions.
Journal ArticleDOI
A signature motif in transcriptional co-activators mediates binding to nuclear receptors.
TL;DR: It is proposed that the LXXLL motif is a signature sequence that facilitates the interaction of different proteins with nuclear receptors, and is thus a defining feature of a new family of nuclear proteins.