Key nodes of a microRNA network associated with the integrated mesenchymal subtype of high-grade serous ovarian cancer.
Yan Sun,Fei Guo,Marina Bagnoli,Feng Xia Xue,Baocun Sun,Ilya Shmulevich,Delia Mezzanzanica,Ke Xin Chen,Anil K. Sood,Da Yang,Wei Zhang +10 more
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TLDR
It is found that integrating mRNA and microRNA data revealed an integrated mesenchymal subtype that is consistently associated with poor survival in multiple cohorts of patients with serous ovarian cancer, consisting of 8 major miRNAs and 214 mRNAs.Abstract:
Metastasis is the main cause of cancer mortality. One of the initiating events of cancer metastasis of epithelial tumors is epithelial-to-mesenchymal transition (EMT), during which cells dedifferentiate from a relatively rigid cell structure/morphology to a flexible and changeable structure/morphology often associated with mesenchymal cells. The presence of EMT in human epithelial tumors is reflected by the increased expression of genes and levels of proteins that are preferentially present in mesenchymal cells. The combined presence of these genes forms the basis of mesenchymal gene signatures, which are the foundation for classifying a mesenchymal subtype of tumors. Indeed, tumor classification schemes that use clustering analysis of large genomic characterizations, like The Cancer Genome Atlas (TCGA), have defined mesenchymal subtype in a number of cancer types, such as high-grade serous ovarian cancer and glioblastoma. However, recent analyses have shown that gene expression-based classifications of mesenchymal subtypes often do not associate with poor survival. This “paradox” can be ameliorated using integrated analysis that combines multiple data types. We recently found that integrating mRNA and microRNA (miRNA) data revealed an integrated mesenchymal subtype that is consistently associated with poor survival in multiple cohorts of patients with serous ovarian cancer. This network consists of 8 major miRNAs and 214 mRNAs. Among the 8 miRNAs, 4 are known to be regulators of EMT. This review provides a summary of these 8 miRNAs, which were associated with the integrated mesenchymal subtype of serous ovarian cancer.read more
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References
More filters
Journal ArticleDOI
MicroRNA profiling of sporadic and hereditary medullary thyroid cancer identifies predictors of nodal metastasis, prognosis and potential therapeutic targets.
Deepak Thomas Abraham,Nicole Jackson,Justin S. Gundara,Jing Ting Zhao,Anthony J. Gill,Leigh Delbridge,Bruce G. Robinson,Stan B. Sidhu +7 more
TL;DR: The data indicate that miRNAs play a pivotal role in the biology of MTC and represent an important class of prognostic biomarkers and therapeutic targets warranting further investigation.
Journal ArticleDOI
MicroRNA-29c functions as a tumor suppressor by direct targeting oncogenic SIRT1 in hepatocellular carcinoma
H. J. Bae,Ji Heon Noh,Kim Jin,J. W. Eun,Kwang Hwa Jung,Minjoong Kim,Y. G. Chang,Qingyu Shen,Sae-Woong Kim,Won Sang Park,Joo-Yong Lee,Suk Woo Nam +11 more
TL;DR: It is suggested that miR-29c functions as a tumor suppressor by regulating abnormal Sirtuin 1 activity in liver by binding to 3′-untranslated region of SIRT1 mRNA causing translational inhibition in liver cancer cells.
Journal ArticleDOI
miR-101 is down-regulated by the hepatitis B virus x protein and induces aberrant DNA methylation by targeting DNA methyltransferase 3A
TL;DR: HBx-mediated miR-101 down-regulation and DNMT3A up-regulation supported the enhanced DNA methylation of several tumor-suppressor genes in HBx-expressing cells and may provide novel mechanistic insights into HBV-mediated hepatocarcinogenesis.
Journal ArticleDOI
Quantitative proteomic profiling of prostate cancer reveals a role for miR-128 in prostate cancer
Amjad Khan,Laila M. Poisson,Vadiraja B. Bhat,Damian Fermin,Rong Zhao,Shanker Kalyana-Sundaram,George Michailidis,Alexey I. Nesvizhskii,Gilbert S. Omenn,Arul M. Chinnaiyan,Arun Sreekumar +10 more
TL;DR: In this article, the authors examined the proteomic alterations in a cohort of 15 prostate-derived tissues that included five each from adjacent benign prostate, clinically localized prostate cancer, and metastatic disease from distant sites.
Journal ArticleDOI
DCLK1 Regulates Pluripotency and Angiogenic Factors via microRNA-Dependent Mechanisms in Pancreatic Cancer
Sripathi M. Sureban,Randal May,Dongfeng Qu,Nathaniel Weygant,Parthasarathy Chandrakesan,Naushad Ali,Stan Lightfoot,Stan Lightfoot,Panayotis Pantazis,Chinthalapally V. Rao,Russell G. Postier,Courtney W. Houchen,Courtney W. Houchen +12 more
TL;DR: DCLK1 plays a significant master regulatory role in pancreatic tumorigenesis through the regulation of multiple tumor suppressor miRNAs and their downstream pro-tumorigenic pathways according to a luciferase-based reporter assay.
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