Kinesin transports RNA: isolation and characterization of an RNA-transporting granule.
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TLDR
This work isolated a large RNase-sensitive granule (size: 1000S approximately) as a binding partner of conventional kinesin (KIF5) and identified a total of 42 proteins with mRNAs for CaMKIIalpha and Arc in the granule.About:
This article is published in Neuron.The article was published on 2004-08-19 and is currently open access. It has received 1060 citations till now. The article focuses on the topics: RNA transport & RNA.read more
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Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6
Caroline Vance,Boris Rogelj,Tibor Hortobágyi,Kurt J. De Vos,Agnes L. Nishimura,Jemeen Sreedharan,Xun Hu,Bradley N. Smith,Deborah Ruddy,Paul Wright,Jeban Ganesalingam,Kelly L. Williams,Vineeta B. Tripathi,Safa Al-Saraj,Ammar Al-Chalabi,P. Nigel Leigh,Ian P. Blair,Garth A. Nicholson,Garth A. Nicholson,Jackie de Belleroche,Jean-Marc Gallo,Christopher C.J. Miller,Christopher C.J. Miller,Christopher Shaw +23 more
TL;DR: A missense mutation in the gene encoding fused in sarcoma (FUS) in a British kindred, linked to ALS6, is identified, which suggests that a common mechanism may underlie motor neuron degeneration.
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Cell-free Formation of RNA Granules: Low Complexity Sequence Domains Form Dynamic Fibers within Hydrogels
Masato Kato,Tina W. Han,Shanhai Xie,Kevin Y. Shi,Xinlin Du,Leeju C. Wu,Hamid Mirzaei,Elizabeth J. Goldsmith,Jamie Longgood,Jimin Pei,Jimin Pei,Nick V. Grishin,Douglas E. Frantz,Jay W. Schneider,She Chen,Lin Li,Michael R. Sawaya,David Eisenberg,Robert Tycko,Steven L. McKnight +19 more
TL;DR: It is discovered that exposure of cell or tissue lysates to a biotinylated isoxazole (b-isox) chemical precipitated hundreds of RNA-binding proteins with significant overlap to the constituents of RNA granules, offering a framework for understanding the function of LC sequences as well as an organizing principle for cellular structures that are not membrane bound.
Journal ArticleDOI
Kinesin superfamily motor proteins and intracellular transport
TL;DR: The mechanisms by which different kinesin recognize and bind to specific cargos, as well as how kinesins unload cargo and determine the direction of transport, have now been identified and open exciting new areas of kinesIn research.
Journal ArticleDOI
Molecular Motors in Neurons: Transport Mechanisms and Roles in Brain Function, Development, and Disease
TL;DR: Recent studies have begun to clarify the mechanisms of cargo selection and directional transport in subcellular compartments and molecular genetics has revealed unexpected roles for molecular motors in brain wiring, neuronal survival, neuronal plasticity, higher brain function, and control of central nervous system and peripheral nervous system development.
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Fragile X Syndrome: Loss of Local mRNA Regulation Alters Synaptic Development and Function
TL;DR: New studies suggest a possible local function of FMRP in axons that may be important for guidance, synaptic development, and formation of neural circuits.
References
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Journal ArticleDOI
Identification of a novel force-generating protein, kinesin, involved in microtubule-based motility
Ronald D. Vale,Ronald D. Vale,Ronald D. Vale,Thomas S. Reese,Michael P. Sheetz,Michael P. Sheetz +5 more
TL;DR: The partial purification of a protein from squid giant axons and optic lobes that induces microtubule-based movements is reported and there is a homologous protein in bovine brain, for which the name kinesin is proposed.
Journal ArticleDOI
Kinesin and Dynein Superfamily Proteins and the Mechanism of Organelle Transport
TL;DR: This review focuses on the molecular mechanism of organelle transport in cells and describes kinesin and dynein superfamily proteins.
Book
Culturing nerve cells
Gary Banker,Kimberly Goslin +1 more
TL;DR: A user's guide to types of nerve cell cultures, their advantages and limitations, and tissue culture methods for the study of myelination.
Journal ArticleDOI
Arc, a growth factor and activity-regulated gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites
Gregory L. Lyford,Kanato Yamagata,Walter E. Kaufmann,Carol A. Barnes,Laura K. Sanders,Neal G. Copeland,Debra J. Gilbert,Nancy A. Jenkins,Anthony Lanahan,Paul F. Worley +9 more
TL;DR: Analysis of the deduced amino acid sequence indicates a region of homology with alpha-spectrin, and observations suggest that Arc may play a role in activity-dependent plasticity of dendrites.
Journal ArticleDOI
Role for rapid dendritic protein synthesis in hippocampal mGluR-dependent long-term depression.
TL;DR: Local postsynaptic protein synthesis, triggered by synaptic activation of metabotropic glutamate receptors, was found to modify synaptic transmission within minutes.
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Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6
Caroline Vance,Boris Rogelj,Tibor Hortobágyi,Kurt J. De Vos,Agnes L. Nishimura,Jemeen Sreedharan,Xun Hu,Bradley N. Smith,Deborah Ruddy,Paul Wright,Jeban Ganesalingam,Kelly L. Williams,Vineeta B. Tripathi,Safa Al-Saraj,Ammar Al-Chalabi,P. Nigel Leigh,Ian P. Blair,Garth A. Nicholson,Garth A. Nicholson,Jackie de Belleroche,Jean-Marc Gallo,Christopher C.J. Miller,Christopher C.J. Miller,Christopher Shaw +23 more