Journal ArticleDOI
Kukoamine A attenuates insulin resistance and fatty liver through downregulation of Srebp-1c.
Reads0
Chats0
TLDR
It is shown that KuA significantly inhibited the increase of fasting blood glucose level and insulin level, and the glucose levels in response to glucose and insulin load in HFD-fed mice, which was in a dose-dependent manner.About:
This article is published in Biomedicine & Pharmacotherapy.The article was published on 2017-05-01. It has received 27 citations till now. The article focuses on the topics: Insulin resistance & Fatty liver.read more
Citations
More filters
Journal ArticleDOI
Herbal drug discovery for the treatment of nonalcoholic fatty liver disease
Tingting Yan,Nana Yan,Ping Wang,Ping Wang,Yangliu Xia,Yangliu Xia,Haiping Hao,Guangji Wang,Frank J. Gonzalez +8 more
TL;DR: In this review, a new model called “multiple organs-multiple hits” is proposed to explain mechanisms of NASH progression and the effects and mechanisms of the frequently-studied THM-yielded single anti-NAFLD drug candidates and multiple herb medicines are reviewed.
Journal ArticleDOI
Acacetin from Traditionally Used Saussurea involucrata Kar. et Kir. Suppressed Adipogenesis in 3T3-L1 Adipocytes and Attenuated Lipid Accumulation in Obese Mice.
Chian-Jiun Liou,Shu-Ju Wu,Shu-Ju Wu,Li-Chen Chen,Kuo-Wei Yeh,Chih-Ying Chen,Wen-Chung Huang,Wen-Chung Huang +7 more
TL;DR: It is demonstrated that acacetin inhibited adipogenesis in adipocytes and in obese mice, and reduced both body weight and visceral adipose tissue weight.
Journal ArticleDOI
Potential Therapeutic Benefits of Herbs and Supplements in Patients with NAFLD
Brandon J Perumpail,Andrew A. Li,Umair Iqbal,Sandy Sallam,Neha D Shah,Waiyee Kwong,George Cholankeril,Donghee Kim,Aijaz Ahmed +8 more
TL;DR: Preliminary data on several herbs have demonstrated promising antioxidant, anti-inflammatory,Anti-apoptotic, and anti-adipogenic properties that may help curtail the progression of NAFLD/NASH.
Journal ArticleDOI
The Chemistry and Health Benefits of Dietary Phenolamides
TL;DR: The studies on phenolamides are still in the infancy stage and additional health benefits, including anti-inflammatory, antioxidant, anti-itch, and anti-atherogenic activities, may have yet to be identified.
Journal ArticleDOI
A Metabolomics Approach to Investigate Kukoamine B-A Potent Natural Product With Anti-diabetic Properties.
Yuanyuan Li,Delisha A. Stewart,Xiao-Min Ye,Li-Hua Yin,Wimal Pathmasiri,Susan McRitchie,Timothy R. Fennell,Hon-Yeung Cheung,Susan Sumner +8 more
TL;DR: The research from holistic and systemic views supports the conclusion that KB is the bioactive compound of LyC for managing T2DM, and suggests KB as a nutraceutical or a pharmaceutical candidate for T2D treatment, and provides insights related to metformin and rosiglitazone action.
References
More filters
Journal ArticleDOI
Global epidemiology of nonalcoholic fatty liver disease—Meta‐analytic assessment of prevalence, incidence, and outcomes
Zobair M. Younossi,Zobair M. Younossi,Aaron B. Koenig,Dinan Abdelatif,Yousef Fazel,Linda Henry,Mark Wymer,Mark Wymer +7 more
TL;DR: As the global epidemic of obesity fuels metabolic conditions, the clinical and economic burden of NAFLD will become enormous, and random‐effects models were used to provide point estimates of prevalence, incidence, mortality and incidence rate ratios.
Journal ArticleDOI
Protein Sensors for Membrane Sterols
TL;DR: Recent advances that explain how cells employ an ensemble of membrane-embedded proteins to monitor sterol concentrations and adjust sterol synthesis and uptake are discussed.
Journal ArticleDOI
Flavonoids as anti-inflammatory agents: implications in cancer and cardiovascular disease.
TL;DR: This review summarizes the known mechanisms involved in the anti-inflammatory activity of flavonoids and the implications of these effects on the protection against cancer and cardiovascular disease.
Journal ArticleDOI
Diabetic dyslipidaemia: from basic research to clinical practice*
TL;DR: Recent discoveries have established the transcription factors including PPARs, SREBP-1 and LXRs as the key regulators of lipid assembly in the liver as a new target to tailor more efficient drugs to treat diabetic dyslipidaemia.
Journal ArticleDOI
Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lep(ob)/Lep(ob) mice.
Naoya Yahagi,Hitoshi Shimano,Alyssa H. Hasty,Takashi Matsuzaka,Tomohiro Ide,Tomohiro Yoshikawa,Michiyo Amemiya-Kudo,Sachiko Tomita,Hiroaki Okazaki,Yoshiaki Tamura,Yoko Iizuka,Ken Ohashi,Jun-ichi Osuga,Kenji Harada,Takanari Gotoda,Ryozo Nagai,Shun Ishibashi,Nobuhiro Yamada +17 more
TL;DR: SREBP-1 regulation of lipogenesis is highly involved in the development of fatty livers but does not seem to be a determinant of obesity in Lep ob /Lep ob mice.