Label-free Proteomic Analysis of Exosomes Derived from Inducible Hepatitis B Virus-Replicating HepAD38 Cell Line.
Xiaofang Jia,Jieliang Chen,Dominik A. Megger,Xiaonan Zhang,Maya Kozlowski,Lijun Zhang,Zhong Fang,Jin Li,Qiaofang Chu,Min Wu,Yaming Li,Barbara Sitek,Zhenghong Yuan +12 more
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TLDR
In this work, an HBV-inducible cell line HepAD38 was used to directly compare changes in the protein content of exosomes secreted from HepAD 38 cells with or without HBV replication, revealing the composition and potential function ofExosomes produced duringHBV replication and providing a new perspective on the role of exOSomes inHBV-host interaction.About:
This article is published in Molecular & Cellular Proteomics.The article was published on 2017-04-01 and is currently open access. It has received 47 citations till now. The article focuses on the topics: Microvesicles & Viral replication.read more
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Proteomic Profiling of Serum Exosomes From Patients With Metastatic Gastric Cancer.
TL;DR: The present study provided a comprehensive description of the serum exosome proteome of m GC patients, which could be an excellent resource for further studies of mGC.
Journal ArticleDOI
Extracellular Vesicles in the Pathogenesis of Viral Infections in Humans.
TL;DR: This review examines the current literature on EVs to explore the complex role of EVs in the enhancement, inhibition, and potential use as a nanotherapeutic against clinically relevant viruses, focusing on neurotropic viruses.
Journal ArticleDOI
Extracellular Vesicles in Viral Infections: Two Sides of the Same Coin?
TL;DR: Understanding the role of EVs during viral infections is crucial to comprehend viral mechanisms and respond better to emerging viral diseases.
Journal ArticleDOI
Immunoregulatory Effects of Myeloid-Derived Suppressor Cell Exosomes in Mouse Model of Autoimmune Alopecia Areata.
Margot Zöller,Kun Zhao,Natalia Kutlu,Nathalie Bauer,Jan Provaznik,Thilo Hackert,Martina Schnölzer +6 more
TL;DR: Changes in leukocyte mRNA seen after treatment of AA mice with MDSC-Exo sustainably supports the strong impact on the adaptive and the non-adaptive immune system, with Treg expansion being a dominant feature.
Journal ArticleDOI
Exosomes Modulate the Viral Replication and Host Immune Responses in HBV Infection.
TL;DR: The role of exosomes is pointed out, including how they could directly participate in HBV replication, modulate immune response during HBV infections, and how exosomal RNAs and proteins might be selected as novel biomarkers for the diagnosis ofHBV infections.
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