Large artery ischaemic stroke in severe acute respiratory syndrome (SARS).
T. Umapathi,Ai Ching Kor,Narayanaswamy Venketasubramanian,C. C. Tchoyoson Lim,Boon Chuan Pang,Tseng Tsai Yeo,Cheng Chuan Lee,Poh Lian Lim,Poh Lian Lim,Kuperan Ponnudurai,Khoon Leong Chuah,Puay Hoon Tan,Dessmon Y.H. Tai,Sze Peng Brenda Ang +13 more
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TLDR
It is believed that increased vigilance against stroke and other thrombotic complications among critically-ill SARS patients in future outbreaks is needed, especially if treatment such as intravenous immunoglobulin, that increases pro-thrombosis tendency, is contemplated.Abstract:
Of the 206 patients who contracted Severe Acute Respiratory Syndrome (SARS) in Singapore five developed large artery cerebral infarctions. Four patients were critically-ill and three died. Intravenous immunoglobulin was given to three patients. An increased incidence of deep venous thrombosis and pulmonary embolism was also observed among the critically-ill patients. We believe our experience warrants an increased vigilance against stroke and other thrombotic complications among critically-ill SARS patients in future outbreaks, especially if treatment such as intravenous immunoglobulin, that increases pro-thrombotic tendency, is contemplated.read more
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COVID-19 and Thrombotic or Thromboembolic Disease: Implications for Prevention, Antithrombotic Therapy, and Follow-up
Behnood Bikdeli,Mahesh V. Madhavan,David Jiménez,Taylor Chuich,Isaac Dreyfus,Elissa Driggin,Caroline Der Nigoghossian,Walter Ageno,Mohammad Madjid,Yutao Guo,Liang V. Tang,Yu Hu,Jay Giri,Mary Cushman,Isabelle Quéré,Evangelos Dimakakos,C. Michael Gibson,C. Michael Gibson,Giuseppe Lippi,Emmanuel J. Favaloro,Jawed Fareed,Joseph A. Caprini,Alfonso Tafur,John R. Burton,Dominic P. Francese,Elizabeth Y. Wang,Anna Falanga,Claire McLintock,Beverley J. Hunt,Alex C. Spyropoulos,Geoffrey D. Barnes,John W. Eikelboom,John W. Eikelboom,Ido Weinberg,Sam Schulman,Marc Carrier,Gregory Piazza,Gregory Piazza,Joshua A. Beckman,P. Gabriel Steg,Gregg W. Stone,Stephan Rosenkranz,Samuel Z. Goldhaber,Samuel Z. Goldhaber,Sahil A. Parikh,Manuel Monreal,Harlan M. Krumholz,Stavros Konstantinides,Jeffrey I. Weitz,Gregory Y.H. Lip,Gregory Y.H. Lip +50 more
TL;DR: The current understanding of the pathogenesis, epidemiology, management and outcomes of patients with COVID-19 who develop venous or arterial thrombosis, and of those with preexistingThrombotic disease who develop CO VID-19 are reviewed.
Journal ArticleDOI
Large-Vessel Stroke as a Presenting Feature of Covid-19 in the Young.
Thomas J Oxley,J Mocco,Shahram Majidi,Christopher P. Kellner,Hazem Shoirah,I. Paul Singh,Reade De Leacy,Tomoyoshi Shigematsu,Travis R. Ladner,Kurt A. Yaeger,Maryna Skliut,Jesse Weinberger,Neha S. Dangayach,Joshua B. Bederson,Stanley Tuhrim,Johanna T Fifi +15 more
TL;DR: Five patients younger than 50 years of age with large-vessel stroke and Covid-19 infection presented to a health system in New York City over a 2-week period with signs of stroke and infection.
Journal ArticleDOI
The emerging spectrum of COVID-19 neurology: clinical, radiological and laboratory findings.
Ross W. Paterson,Ross W. Paterson,Rachel Brown,Laura A Benjamin,Laura A Benjamin,Ross Nortley,Ross Nortley,Sarah Wiethoff,Sarah Wiethoff,Tehmina Bharucha,Tehmina Bharucha,Tehmina Bharucha,Dipa L Jayaseelan,Dipa L Jayaseelan,Guru Kumar,Rhian E Raftopoulos,Laura Zambreanu,Laura Zambreanu,Vinojini Vivekanandam,Anthony Khoo,Ruth Geraldes,Ruth Geraldes,Krishna Chinthapalli,Krishna Chinthapalli,Elena Boyd,Hatice Tuzlali,Gary Price,Gerry Christofi,Jasper M. Morrow,Jasper M. Morrow,Patricia McNamara,Benjamin C Mcloughlin,Soon Tjin Lim,Puja Mehta,Viva Levee,Stephen Keddie,Wisdom Yong,S Anand Trip,S Anand Trip,Alexander J.M. Foulkes,Alexander J.M. Foulkes,Gary Hotton,Thomas D. Miller,Alex Everitt,Christopher Carswell,Nicholas W. S. Davies,Michael Yoong,David Attwell,Jemeen Sreedharan,Eli Silber,Jonathan M. Schott,Arvind Chandratheva,Richard J. Perry,Robert Simister,Anna M. Checkley,Nicky Longley,Simon F. Farmer,Francesco Carletti,Catherine F Houlihan,Maria Thom,Michael P. Lunn,Jennifer Spillane,Jennifer Spillane,Robin Howard,Robin Howard,Angela Vincent,Angela Vincent,David J. Werring,Chandrashekar Hoskote,Hans Rolf Jäger,Hans Rolf Jäger,Hadi Manji,Hadi Manji,Michael S. Zandi,Michael S. Zandi +74 more
TL;DR: A case series of 43 patients with neurological complications of SARS-CoV-2 infection includes encephalopathies, encephalitis, acute disseminated encephalomyelitis with haemorrhagic change, transverse myelitis, ischaemic stroke, and Guillain-Barré syndrome.
Journal ArticleDOI
Acute Cerebrovascular Disease Following COVID-19: A Single Center, Retrospective, Observational Study
Yanan Li,Man Li,Mengdie Wang,Yifan Zhou,Jiang Chang,Ying Xian,David Z. Wang,Ling Mao,Huijuan Jin,Bo Hu,Bo Hu +10 more
TL;DR: The findings suggest that older patients with risk factors are more likely to develop CVD and the development of CVD is an important negative prognostic factor which requires further study to identify optimal management strategy to combat the COVID-19 outbreak.
Journal ArticleDOI
Coagulation disorders in coronavirus infected patients: COVID-19, SARS-CoV-1, MERS-CoV and lessons from the past.
TL;DR: Preliminary reports on COVID-19 patients’ clinical and laboratory findings include thrombocytopenia, elevated D-dimer, prolonged prothrombin time, and disseminated intravascular coagulation.
References
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Journal ArticleDOI
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Journal ArticleDOI
Recent bacterial and viral infection is a risk factor for cerebrovascular ischemia: Clinical and biochemical studies
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TL;DR: Recent infection is an independent risk factor for acute cerebrovascular ischemia and its role appears to be more important in younger age groups.
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