Journal ArticleDOI
Lipids for Taste masking and Taste assessment in pharmaceutical formulations.
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TLDR
In this paper, a review explores applications of lipids in masking the bitter taste in pharmaceutical formulations and significant role of lipid in evaluation of taste and palatability, also known as electronic tongue or e-tongue, lipids are used in preparing taste sensing membranes which are subsequently used to prepare taste sensors.About:
This article is published in Chemistry and Physics of Lipids.The article was published on 2021-03-01. It has received 12 citations till now. The article focuses on the topics: Taste.read more
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Journal ArticleDOI
Screening of characteristic umami substances in preserved egg yolk based on the electronic tongue and UHPLC-MS/MS
TL;DR: In this article, the electronic tongue, ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) and multivariate statistical methods were used to explore the characteristic taste of preserved egg yolk.
Journal ArticleDOI
Orodispersible films - Recent developments and new applications in drug delivery and therapy.
TL;DR: Orodispersible films (ODF) as discussed by the authors are innovative drug formulations that introduce a promising approach to pharmacotherapy, which represent single- or multi-layer polymer films that show sufficient stability but disintegrate easily.
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Nanostructured lipid carriers and their potential applications for versatile drug delivery via oral administration
TL;DR: Nanostructured lipid carriers (NLCs) have emerged as a promising strategy for improving therapeutic compound oral bioavailability, not only due to nanomaterial advantages, but also due to lipid ingredients themselves, such as preventing enzyme degradation, taste masking, and especially favorable uptake by chylomicron pathways to the lymphatic drainage system as discussed by the authors .
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Formulation and assessment of hydroxyzine HCL solid lipid nanoparticles by dual emulsification technique for transdermal delivery.
Dalia Farag A. El-Telbany,Rania Farag A. El-Telbany,Sherin Zakaria,Kawkab A. Ahmed,Yasmin A. El-Feky +4 more
TL;DR: In this paper, a dual phase drug delivery rate across the intact skin, to enhance HHCL permeation through the stratum corneum, to assess the peripheral H1-antihistaminic activity and the extent to which HHCL was systemically absorbed from transdermal gel loaded with solid lipid nanoparticles (SLNs), as well as to avoid its extreme bitterness.
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Research Progress of Preparation Technology of Ion-Exchange Resin Complexes
TL;DR: In this article , the authors summarized the technologies employed in these studies from four aspects: IER screening principles, combining technologies, characterization methods, and in vitro and in vivo release of drug-resinate complexes.
References
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Journal ArticleDOI
Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs
TL;DR: The mechanisms by which lipids and lipidic excipients affect the oral absorption of lipophilic drugs are detailed and a perspective on the possible future applications of lipid-based delivery systems is provided.
Journal ArticleDOI
A comprehensive classification system for lipids
Eoin Fahy,Shankar Subramaniam,H. Alex Brown,Christopher K. Glass,Alfred H. Merrill,Robert C. Murphy,Christian R. H. Raetz,David W. Russell,Yousuke Seyama,Walter A. Shaw,Takao Shimizu,Friedrich Spener,Gerrit van Meer,Michael S. VanNieuwenhze,Stephen H. White,Joseph L. Witztum,Edward A. Dennis +16 more
TL;DR: A comprehensive classification of lipids with a common platform that is compatible with informatics requirements has been developed to deal with the massive amounts of data that will be generated by the lipid community.
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T2Rs function as bitter taste receptors.
Jayaram Chandrashekar,Ken Mueller,Mark A. Hoon,Elliot Adler,Luxin Feng,Wei Guo,Charles S. Zuker,Nicholas J. P. Ryba +7 more
TL;DR: A heterologous expression system is used to show that specific T2Rs function as bitter taste receptors, and these findings provide a plausible explanation for the uniform bitter taste that is evoked by many structurally unrelated toxic compounds.
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Melt extrusion: from process to drug delivery technology
TL;DR: Improved bioavailability was achieved again demonstrating the value of the technology as a drug delivery tool, with particular advantages over solvent processes like co-precipitation.
Journal ArticleDOI
Pharmaceutical Applications of Hot-Melt Extrusion: Part I
Michael M. Crowley,Feng Zhang,Michael A. Repka,Sridhar Thumma,Sampada B. Upadhye,Sunil Kumar Battu,James W. McGinity,Charles R. Martin +7 more
TL;DR: The pharmaceutical applications of hot-melt extrusion, including equipment, principles of operation, and process technology, are reviewed and the physicochemical properties of the resultant dosage forms are described.