Journal ArticleDOI
Low-LET Proton Irradiation of A549 Non-small Cell Lung Adenocarcinoma Cells: Dose Response and RBE Determination
TLDR
Comparisons with X ray results indicate that proton irradiation at 10 keV/μm enhanced the tumor radiosensitivity with a significant dose-dependent decrease in the survival fraction.Abstract:
Since 1957, broad proton beam radiotherapy with a spread out Bragg peak has been used for cancer treatment. More recently, studies on the use of proton therapy in the treatment of non-small cell lung cancer (NSCLC) were performed and although the benefit of using protons for the treatment of NSCLC is recognized, more work is needed to gather additional data for the understanding of cell response. Human A549 cell survival was evaluated by colony forming assay 11 days after 10 keV/μm proton beam irradiation at 0.1 and 1 Gy/min. The residual energy of the proton beam at the location of the irradiated cells was 3.9 MeV. In parallel, early effects on the cell viability and DNA damage were assessed and DNA synthesis was measured. The survival curve obtained was fitted with both the linear and the induced-repair models, as a hyper-radiosensitivity was evidenced at very low doses. Above 0.5 Gy, a linear shape was observed with the α parameter equal to 0.824 ± 0.029 Gy−1. In addition, early cell death and cell pro...read more
Citations
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Book ChapterDOI
Predictive Assessment of Biological Damage Due to Ion Beams
TL;DR: An extensive comparison with experimental data for cell survival probability demonstrates the validity of the MSA to predict the macroscopic effects of ionizing radiation through an understanding of biological damage on the nanoscale.
Journal ArticleDOI
Taking Advantage of the Senescence-Promoting Effect of Olaparib after X-ray and Proton Irradiation Using the Senolytic Drug, ABT-263
Camille Huart,Maude Fransolet,Catherine Demazy,Benjamin Le Calvé,Stéphane Lucas,Carine Michiels,A-C Wéra +6 more
TL;DR: It was shown that combining RT (photons and protons) to noncytotoxic concentration of PARP inhibitor, Olaparib, induced a cell line-dependent senescence-like phenotype, demonstrating that a combination of RT with PARP inhibition and senolytics could be a promising therapeutic approach for cancer patients.
RADIOBIOLOGY SPECIAL FEATURE: REVIEW ARTICLE New challenges in high-energy particle radiobiology
TL;DR: The role of individual susceptibility in therapy and risk is obviously a major topic in radiation research in general, and for ion radiobiology as well as mentioned in this paper, where beyond the relative biological effectiveness (RBE) of the energetic particles, the tissue response is considered.
Journal ArticleDOI
Simulations of a vacuum window and in-beam ion detection for use in radiobiological experiments with 50 MeV particle beams
TL;DR: In this article, the effects of different elements on an incident beam of 50 MeV protons were investigated using the Monte Carlo particle transport code MCNPX 2.5, and a 200 nm thick silicon nitride vacuum window was found to have the least effect on the incident beam.
References
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Book
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