Journal ArticleDOI
Low-LET Proton Irradiation of A549 Non-small Cell Lung Adenocarcinoma Cells: Dose Response and RBE Determination
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Comparisons with X ray results indicate that proton irradiation at 10 keV/μm enhanced the tumor radiosensitivity with a significant dose-dependent decrease in the survival fraction.Abstract:
Since 1957, broad proton beam radiotherapy with a spread out Bragg peak has been used for cancer treatment. More recently, studies on the use of proton therapy in the treatment of non-small cell lung cancer (NSCLC) were performed and although the benefit of using protons for the treatment of NSCLC is recognized, more work is needed to gather additional data for the understanding of cell response. Human A549 cell survival was evaluated by colony forming assay 11 days after 10 keV/μm proton beam irradiation at 0.1 and 1 Gy/min. The residual energy of the proton beam at the location of the irradiated cells was 3.9 MeV. In parallel, early effects on the cell viability and DNA damage were assessed and DNA synthesis was measured. The survival curve obtained was fitted with both the linear and the induced-repair models, as a hyper-radiosensitivity was evidenced at very low doses. Above 0.5 Gy, a linear shape was observed with the α parameter equal to 0.824 ± 0.029 Gy−1. In addition, early cell death and cell pro...read more
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Inhibitory effects of proton beam irradiation on integrin expression and signaling pathway in human colon carcinoma HT29 cells
TL;DR: Proton beam irradiation can inhibit metastatic potential, including cell adhesion and migration, by modulating the gene expression of molecules involved in integrin trafficking and integrin-mediated signaling, which are necessary for tumor progression.
Journal ArticleDOI
Simulating Space Radiation-Induced Breast Tumor Incidence Using Automata
TL;DR: A formalism using cellular automata to model the long-term effects of ionizing radiation in human breast for different radiation qualities and predicts that RBE for breast cancer induced by cosmic radiation would be maximum at 220 keV/μm.
Journal ArticleDOI
Toward computer simulation of high-LET in vitro survival curves.
TL;DR: A Monte Carlo based computer program able to predict the survival fraction of cells irradiated in vitro with a broad beam of high linear energy transfer particles, with benefits of time that would have been spent performing time-consuming clonogenic assays, the capacity to estimate survival fractions of cell lines not forming colonies and possibly the evaluation of radiosensitivity parameters of given individuals.
Journal ArticleDOI
Applications of High-Throughput Clonogenic Survival Assays in High-LET Particle Microbeams.
Antonios Georgantzoglou,Michael J. Merchant,J. C. G. Jeynes,Natalie Mayhead,Natasha Punia,Rachel E. Butler,Rajesh Jena +6 more
TL;DR: Validation shows the efficiency of the proposed cell detection and tracking method in finding cell divisions in high-throughput charged particle therapy experiments with high-LET radiation.
Journal ArticleDOI
Imaging issues specific to hadrontherapy (proton, carbon, helium therapy and other charged particles) for radiotherapy planning, setup, dose monitoring and tissue response assessment.
Juliette Thariat,Joel Herault,A. Beddok,Loïc Feuvret,Denis Dauvergne,Michael Gérard,Jacques Balosso,Georges Noël,S. Valable +8 more
TL;DR: The current review addresses current status of imaging in proton therapy and the drawbacks of photon-based imaging for hadrons, and addresses requirements in hadrontherapy planning with respect to multimodal imaging for proper target and organ at risk definition.
References
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