Journal ArticleDOI
Low-LET Proton Irradiation of A549 Non-small Cell Lung Adenocarcinoma Cells: Dose Response and RBE Determination
TLDR
Comparisons with X ray results indicate that proton irradiation at 10 keV/μm enhanced the tumor radiosensitivity with a significant dose-dependent decrease in the survival fraction.Abstract:
Since 1957, broad proton beam radiotherapy with a spread out Bragg peak has been used for cancer treatment. More recently, studies on the use of proton therapy in the treatment of non-small cell lung cancer (NSCLC) were performed and although the benefit of using protons for the treatment of NSCLC is recognized, more work is needed to gather additional data for the understanding of cell response. Human A549 cell survival was evaluated by colony forming assay 11 days after 10 keV/μm proton beam irradiation at 0.1 and 1 Gy/min. The residual energy of the proton beam at the location of the irradiated cells was 3.9 MeV. In parallel, early effects on the cell viability and DNA damage were assessed and DNA synthesis was measured. The survival curve obtained was fitted with both the linear and the induced-repair models, as a hyper-radiosensitivity was evidenced at very low doses. Above 0.5 Gy, a linear shape was observed with the α parameter equal to 0.824 ± 0.029 Gy−1. In addition, early cell death and cell pro...read more
Citations
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Journal ArticleDOI
Determining if low dose hyper-radiosensitivity (HRS) can be exploited to provide a therapeutic advantage: a cell line study in four glioblastoma multiforme (GBM) cell lines.
TL;DR: Ultra-fractionation is an effective modality for killing glioma cell lines compared with standard 2 Gy dosing when multiple days of treatment are given, and was more effective when given for five consecutive days to a total dose of 10 Gy.
Journal ArticleDOI
Radiation-induced synthetic lethality: combination of poly(ADP-ribose) polymerase and RAD51 inhibitors to sensitize cells to proton irradiation.
TL;DR: It is demonstrated that radiation-induced synthetic lethality might widen the therapeutic window, hence extending the use of PARP inhibitors to patients without BRCAness.
Journal ArticleDOI
Optimizing radiotherapy protocols using computer automata to model tumour cell death as a function of oxygen diffusion processes.
Perrine Paul-Gilloteaux,Vincent Potiron,Gregory Delpon,Stéphane Supiot,Sophie Chiavassa,François Paris,Sylvain V. Costes,Sylvain V. Costes +7 more
TL;DR: A computer model based on translational murine data for in silico testing and optimization of various radiotherapy protocols with respect to tumour resistance and the microenvironment heterogeneity is presented, hypothesizing that tumour control can be optimized by adjusting daily radiation dosage as a function of the degree of hypoxia in the tumour environment.
Journal ArticleDOI
RBE and OER within the spread-out Bragg peak for proton beam therapy: in vitro study at the Proton Medical Research Center at the University of Tsukuba
Ayae Kanemoto,Ryoichi Hirayama,Takashi Moritake,Yoshiya Furusawa,Lue Sun,Takeji Sakae,Akihiro Kuno,Toshiyuki Terunuma,K. Yasuoka,Yutaro Mori,Koji Tsuboi,Hideyuki Sakurai +11 more
TL;DR: Biological homogeneity need not necessarily be taken into account for treatment planning for proton beam therapy at the University of Tsukuba.
Journal ArticleDOI
Multiscale modeling for cancer radiotherapies
TL;DR: The Multiscale approach has integrated the science involved in ion-beam therapy; in the process of the development of MSA, a new physical effect of ion-induced shock waves has been predicted and its effect on the scenario of radiation damage is discussed in detail.
References
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