MAGI-2 orchestrates the localization of backbone proteins in the slit diaphragm of podocytes.
Hiroyuki Yamada,Hiroyuki Yamada,Naritoshi Shirata,Naritoshi Shirata,Shin-ichi Makino,Shin-ichi Makino,Takafumi Miyake,Juan Alejandro Oliva Trejo,Kanae Yamamoto-Nonaka,Mitsuhiro Kikyo,Mitsuhiro Kikyo,Maulana A. Empitu,Ika N. Kadariswantiningsih,Maiko Kimura,Koichiro Ichimura,Hideki Yokoi,Masashi Mukoyama,Akitsu Hotta,Katsuhiko Nishimori,Motoko Yanagita,Katsuhiko Asanuma,Katsuhiko Asanuma +21 more
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TLDR
The role of membrane-associated guanylate kinase inverted 2 (MAGI-2) is focused on in order to investigate mechanisms that orchestrate localization of slit-diaphragm backbone proteins in podocytes and to elucidate a mechanism by which the backbone proteins are maintained.About:
This article is published in Kidney International.The article was published on 2021-02-01 and is currently open access. It has received 14 citations till now. The article focuses on the topics: Nephrin & Podocyte.read more
Citations
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Intestinal Bacterial Translocation Contributes to Diabetic Kidney Disease
TL;DR: In this paper , the effects of disrupted intestinal homeostasis associated with Mitochondrial antiviral signaling protein (MAVS), a component of innate immunity, maintains intestinal integrity was investigated in diabetic kidney disease.
Journal ArticleDOI
Mapping the human kidney using single-cell genomics
Felix Schreibing,Rafael Kramann +1 more
TL;DR: The state of the art of single-cell analyses in kidney research is summarized, including advances in the understanding of kidney embryogenesis and pathomechanisms of several relevant kidney disease entities.
Journal ArticleDOI
Intestinal Bacterial Translocation Contributes to Diabetic Kidney Disease
Hoang Ha Linh,Yasunori Iwata,Yasuko Senda,Yukiko Sakai-Takemori,Yusuke Nakade,Megumi Oshima,Shiori Nakagawa-Yoneda,Hisayuki Ogura,Koichi Sato,Taichiro Minami,Shinji Kitajima,Tadashi Toyama,Yuta Yamamura,Taro Miyagawa,Akinori Hara,Miho Shimizu,Kengo Furuichi,Norihiko Sakai,Hiroyuki Yamada,Katsuhiko Asanuma,Kouji Matsushima,Takashi Wada +21 more
TL;DR: Impaired MAVS signaling both in the kidney and intestine contributes to the disrupted homeostasis, leading to diabetic kidney disease progression.
Journal ArticleDOI
MAGI1, a Scaffold Protein with Tumor Suppressive and Vascular Functions.
Janine Wörthmüller,Curzio Rüegg +1 more
TL;DR: MAGI1 is a cytoplasmic scaffolding protein initially identified as a component of cell-to-cell contacts stabilizing cadherin-mediated cell-cell adhesion in epithelial and endothelial cells.
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Proximity proteomics of synaptopodin provides insight into the molecular composition of the spine apparatus of dendritic spines
TL;DR: Using an in vivo spatial proteomics technique, this work identifies proteins associated with the spine apparatus and validate the specific localization of a subset of them, including Pdlim7, in neurons, allowing for better understanding of brain function in health and disease.
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Positionally Cloned Gene for a Novel Glomerular Protein—Nephrin—Is Mutated in Congenital Nephrotic Syndrome
Marjo Kestilä,Ulla Lenkkeri,Minna Männikkö,Jane Lamerdin,Paula McCready,Heli Putaala,Vesa Ruotsalainen,Takako Morita,Marja Nissinen,Riitta Herva,Clifford E. Kashtan,Leena Peltonen,Christer Holmberg,Anne S. Olsen,Karl Tryggvason,Karl Tryggvason +15 more
TL;DR: A crucial role for this protein in the development or function of the kidney filtration barrier is demonstrated and by Northern and in situ hybridization was shown to be specifically expressed in renal glomeruli.
Journal ArticleDOI
Podocin, a raft-associated component of the glomerular slit diaphragm, interacts with CD2AP and nephrin
Karin Schwarz,Matias Simons,Jochen Reiser,Moin A. Saleem,Christian Faul,Wihelm Kriz,Andrey S. Shaw,Lawrence B. Holzman,Peter Mundel +8 more
TL;DR: It is shown, by immunoelectron microscopy, that podocin localizes to the podocyte foot process membrane, at the insertion site of the slit diaphragm, and it is postulate thatpodocin serves in the structural organization of the slat diaphagm and the regulation of its filtration function.
Journal ArticleDOI
Proteinuria and perinatal lethality in mice lacking NEPH1, a novel protein with homology to NEPHRIN.
Dorit B. Donoviel,Deon D. Freed,Hannes Vogel,David Potter,Edith P. Hawkins,James Barrish,Brian N. Mathur,C. Alexander Turner,Robert S. Geske,Charles A. Montgomery,Michael Starbuck,Mary L. Brandt,Anupma Gupta,Ramiro Ramirez-Solis,Brian Zambrowicz,David R. Powell +15 more
TL;DR: Findings suggest that NEPH1, like NEPHRIN, may play an important role in maintaining the structure of the filtration barrier that prevents proteins from freely entering the glomerular urinary space.
Journal ArticleDOI
A novel multiple PDZ domain-containing molecule interacting with N-methyl-D-aspartate receptors and neuronal cell adhesion proteins.
Kazuyo Hirao,Yutaka Hata,Nobuyuki Ide,Masakazu Takeuchi,Mina Irie,Ikuko Yao,Maki Deguchi,Atsushi Toyoda,Thomas C. Südhof,Yoshimi Takai +9 more
TL;DR: A yeast two-hybrid screening for SAPAP-interacting molecules is performed and a novel protein is identified that has an inverse structure of membrane-associated guanylate kinases with an NH2-terminal GK-like domain followed by two WW and five PDZ domains called S-SCAM (synaptic scaffolding molecule), which may assemble receptors and cell adhesion proteins at synaptic junctions.
Journal ArticleDOI
CD2AP Localizes to the Slit Diaphragm and Binds to Nephrin via a Novel C-Terminal Domain
TL;DR: It is demonstrated thatCD2AP localizes to the slit diaphragm in podocytes using immunoelectron microscopy and that nephrin and CD2AP co-immunoprecipitate from a podocyte cell line, lending further support to the idea that CD2 AP plays a role in the structural integrity of the slitDiaphragms.