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Magnetic nanoparticles: design and characterization, toxicity and biocompatibility, pharmaceutical and biomedical applications.
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Biocompatibility, Pharmaceutical and Biomedical Applications L. Harivardhan Reddy,‡ Jose ́ L. Arias, Julien Nicolas,† and Patrick Couvreur*,†.Abstract:
Biocompatibility, Pharmaceutical and Biomedical Applications L. Harivardhan Reddy,†,‡ Jose ́ L. Arias, Julien Nicolas,† and Patrick Couvreur*,† †Laboratoire de Physico-Chimie, Pharmacotechnie et Biopharmacie, Universite ́ Paris-Sud XI, UMR CNRS 8612, Faculte ́ de Pharmacie, IFR 141, 5 rue Jean-Baptiste Cleḿent, F-92296 Chat̂enay-Malabry, France Departamento de Farmacia y Tecnología Farmaceútica, Facultad de Farmacia, Campus Universitario de Cartuja s/n, Universidad de Granada, 18071 Granada, Spain ‡Pharmaceutical Sciences Department, Sanofi, 13 Quai Jules Guesdes, F-94403 Vitry-sur-Seine, Franceread more
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Targeted Drug Delivery with Polymers and Magnetic Nanoparticles: Covalent and Noncovalent Approaches, Release Control, and Clinical Studies.
TL;DR: This review covers the principles, advantages, and drawbacks of passive and active targeting based on various polymer and magnetic iron oxide nanoparticle carriers with drug attached by both covalent and noncovalent pathways.
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Recent Progress in Rare Earth Micro/Nanocrystals: Soft Chemical Synthesis, Luminescent Properties, and Biomedical Applications
TL;DR: Synthesis, Luminescent Properties, and Biomedical Applications Shili Gai,‡ Chunxia Li,† Piaoping Yang,*,‡ and Jun Lin*,† † state Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences.
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Bimetallic Nanocrystals: Syntheses, Properties, and Applications
TL;DR: A comprehensive review of recent research activities on bimetallic nanocrystals, featuring key examples from the literature that exemplify critical concepts and place a special emphasis on mechanistic understanding.
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Recent progress on magnetic iron oxide nanoparticles: synthesis, surface functional strategies and biomedical applications.
TL;DR: This review focuses on the recent development and various strategies in the preparation, microstructure, and magnetic properties of bare and surface functionalized iron oxide nanoparticles (IONPs); their corresponding biological application was also discussed.
References
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Journal ArticleDOI
Monocrystalline iron oxide nanocompounds (MION): physicochemical properties.
Tueng Shen,Tueng Shen,Ralph Weissleder,Ralph Weissleder,Mikhail Papisov,Mikhail Papisov,Alexei A. Bogdanov,Alexei A. Bogdanov,Thomas J. Brady,Thomas J. Brady +9 more
TL;DR: The physicochemical properties of MION are reported using a variety of analytical techniques to show that a novel monocrystalline iron oxide nanocompound, a stable colloid that enables target specific MR imaging, has an inverse spinel crystal structure.
Journal ArticleDOI
Magnetically mediated hyperthermia: current status and future directions
TL;DR: Magnetic mediated hyperthermia (MMH) as discussed by the authors is a well-known treatment for cancer, which consists of the localization of magnetic particles or seeds within tumour tissue followed by exposure to an externally applied alternating magnetic field to cause them to heat.
Journal ArticleDOI
Efficient magnetic cell labeling with protamine sulfate complexed to ferumoxides for cellular MRI.
Ali S. Arbab,Gene T. Yocum,Heather Kalish,Elaine K. Jordan,Stasia A. Anderson,Aarif Y. Khakoo,Elizabeth J. Read,Joseph A. Frank +7 more
TL;DR: In this article, the authors evaluated the efficiency and toxicity of labeling mammalian cells using two commercially available Food and Drug Administration (FDA)-approved agents, ferumoxides, a suspension of dextran-coated SPIO used as an MRI contrast agent, and protamine sulfate, conventionally used to reverse heparin anticoagulation but also used ex vivo as a cationic transfection agent.
Journal ArticleDOI
Magnetic nanoparticle design for medical applications
Stéphane Mornet,Sébastien Vasseur,Fabien Grasset,Pavel Veverka,Graziella Goglio,Alain Demourgues,Josik Portier,E. Pollert,Etienne Duguet +8 more
TL;DR: Magnetic nanoparticles have attracted attention because of their current and potential usefulness as contrast agents for magnetic resonance imaging (MRI) or colloidal mediators for cancer magnetic hyperthermia as discussed by the authors.
Journal ArticleDOI
Dextran and albumin derivatised iron oxide nanoparticles: influence on fibroblasts in vitro.
TL;DR: The results indicate that the derivatised particles induce alterations in cell behaviour and morphology distinct from the plain particles, suggesting that cell response can be directed via specifically engineered particle surfaces.
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