Major histocompatibility complex susceptibility genes for dermatitis herpetiformis compared with those for gluten-sensitive enteropathy.
A. R. Ahmed,Juan J. Yunis,Deborah Marcus-Bagley,Edmond J. Yunis,Marcela Salazar,Aubrey J. Katz,Zuheir L. Awdeh,Chester A. Alper +7 more
TLDR
The findings suggest that the MHC susceptibility gene for DH is between class II and complotype regions, closest to the complotype, whereas that for GSE is in the class II region.Abstract:
Dermatitis herpetiformis (DH) shares some clinical features and major histocompatibility complex (MHC) markers with gluten-sensitive enteropathy (GSE). We compared MHC haplotypes in 27 patients with DH, 35 patients with GSE, and normal controls. As in GSE, the frequencies of two extended haplotypes, [HLA-B8, SC01, DR3] and [HLA-B44, FC31, DR7], were increased in patients with DH. Distributions of fragments of extended haplotypes, consisting of some but not all of the elements of complete extended haplotypes, were analyzed to attempt to localize a susceptibility gene. Besides complete extended susceptibility haplotypes, (DR3, DQ2) and (DR7, DQ2) fragments were most common in GSE. In contrast, DH showed only a few such fragments but many instances of the fragment (SC01). The differences in distribution of these fragments in the two diseases were highly significant (P < 0.002). HLA-DQ2 and DR3 had the highest odds ratios for GSE, but the highest odds ratio for DH was for the complotype SC01. These findings suggest that the MHC susceptibility gene for DH is between class II and complotype regions, closest to the complotype, whereas that for GSE is in the class II region.read more
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The genetic basis for the association of the 8.1 ancestral haplotype (A1, B8, DR3) with multiple immunopathological diseases
Patricia Price,Campbell S. Witt,Richard J.N. Allcock,David Sayer,Michael J. Garlepp,C.C. Kok,Martyn A. French,Simon Mallal,Frank T. Christiansen +8 more
TL;DR: Several candidate genes in the central MHC have the potential to modulate immune or inflammatory responses in an antigen‐independent manner, as is seen in studies of cultured cells from healthy carriers of the 8.1 AH.
Journal ArticleDOI
Genetic variations in cytokine expression: a risk factor for severity of adult periodontitis.
TL;DR: The finding that host modifying factors are associated with severe periodontitis suggest a biological mechanism by which some individuals, if challenged by bacterial accumulations, may have a more vigorous immunoinflammatory response, leading to more severe clinical disease.
Journal ArticleDOI
Inheritable variable sizes of DNA stretches in the human MHC: conserved extended haplotypes and their fragments or blocks.
Edmond J. Yunis,Charles E. Larsen,Marcelo Fernandez-Vina,Zuheir L. Awdeh,T. Romero,John A. Hansen,Chester A. Alper +6 more
TL;DR: The concept of the conserved extended haplotype (CEH) is updated using HLA allele identification and TNF microsatellites to show that specific combinations of the four blocks form single genetic units with a total haplotype frequency in the Caucasian population of 0.30.
Journal ArticleDOI
Dermatitis herpetiformis and celiac disease are both primarily associated with the HLA-DQ (α1*0501, (β1*02) or the HLA-DQ (α1*03, (β1*0302) heterodimers
TL;DR: It is concluded that dermatitis herpetiformis and celiac disease are associated to the very same HLA-DQ alpha beta heterodimers.
Journal ArticleDOI
The Haplotype Structure of the Human Major Histocompatibility Complex
Chester A. Alper,Chester A. Alper,Charles E. Larsen,Charles E. Larsen,Devendra P. Dubey,Zuheir L. Awdeh,Dolores A. Fici,Edmond J. Yunis,Edmond J. Yunis +8 more
TL;DR: The results suggest that the human genome, including the major histocompatibility complex (MHC), consists largely of 5- to 200-kb blocks of sequence fixity between which random recombination occurs, and the use of statistical analysis rather than direct haplotype determination and counting fails to reveal the details of haplotype structure essential for gene localization.
References
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Journal ArticleDOI
Genetic polymorphism in human glycine-rich beta-glycoprotein.
TL;DR: Electrophoretic studies of fragments from defined types of GBG suggested that GBG cleavage induced by complement or properdin activation in serum occurred through this C moiety, since two variants were detectable in one fragment and two were found in the other fragment.
Journal ArticleDOI
Inherited structural polymorphism of the fourth component of human complement.
Zuheir L. Awdeh,Chester A. Alper +1 more
TL;DR: Close linkage with no crossovers was found between the two C4 loci, allowing the definition of C4AB haplotypes, and between C4 haplotypes and the C2 and BF loci of the human histocompatibility complex.
Journal ArticleDOI
Inherited structural polymorphism in human C2: evidence for genetic linkage between C2 and Bf.
TL;DR: Structural variation in the second component of human complement was identified in about 4% of serum samples from random unrelated individuals of all the major races and suggestive evidence for close linkage between C2 and Bf was obtained.
Journal ArticleDOI
A combination of a particular HLA-DPβ allele and an HLA-DQ heterodimer confers susceptibility to coeliac disease
Teodorica L. Bugawan,Giovanna Angelini,James W. Larrick,Salvatore Auricchio,Giovanni Battista Ferrara,Henry A. Erlich +5 more
TL;DR: A new DNA-based method of HLA-DP typing is used to analyse the distribution of DPβ alleles in a group of coeliac disease patients and healthy controls and suggests that the polymorphic residues at position 69 and at 56 and 57 may be critical in conferring susceptibility.
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Major histocompatibility complex haplotype studies in Ashkenazi Jewish patients with pemphigus vulgaris.
TL;DR: Since the disease is entirely attributable to the presence of an antibody to an intraepidermal intercellular cement substance, it is likely that the class II susceptibility gene (on HLA-B38, SC21, DR4, DQw8, or their segments, in Jewish patients) controls the production of the antibody as a dominantly expressed immune response gene.